| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The sudden cardiac death of children undergoing drug therapy for attention / hyperactivity disorder attracts attention and the influence of drug induced long QT syndrome is assumed as a cause. The QT prolonging action by the drug has large differences among individuals and it is not possible to predict the onset of QT prolongation before drug administration. On the other hand, it is suggested that drug-induced long QT syndrome has an increased risk of onset in individuals with genetic polymorphisms related to QT prolongation, and several single nucleotide polymorphisms (SNPs) are proposed as candidates by genome-wide association study (GWAS) in recent years.
In this study, we investigate the effects of ADHD therapeutic drugs and QT prolonging gene polymorphisms on QT interval using a 24 - hour Holter electrocardiogram and establish an assessment method for cardiovascular event risk in children taking ADHD therapeutic drugs.
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