Search fo predictive markers of long QT syndrome induced by ADHD therapeutic agents in Children and Adlescents
| Project/Area Number |
26461763
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
Takuro Sugai 新潟大学, 医歯学総合病院, 講師 (40571914)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 注意欠如・多動性障害（ADHD） / QT延長症候群 / ゲノムワイド関連解析（GWAS） / アトモキセチン / 24時間ホルター心電図 / 注意欠如・多動性障害 / 薬剤誘発性QT延長症候群 / 心臓突然死 / GWAS / 塩酸メチルフェニデート / 薬剤誘発性QT 延長症候群 / 24 時間ホルター心電図 / ゲノムワイド関連解析 / 関連遺伝子多型 |
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| Outline of Final Research Achievements |
The sudden cardiac death of children undergoing drug therapy for attention / hyperactivity disorder attracts attention and the influence of drug induced long QT syndrome is assumed as a cause. The QT prolonging action by the drug has large differences among individuals and it is not possible to predict the onset of QT prolongation before drug administration. On the other hand, it is suggested that drug-induced long QT syndrome has an increased risk of onset in individuals with genetic polymorphisms related to QT prolongation, and several single nucleotide polymorphisms (SNPs) are proposed as candidates by genome-wide association study (GWAS) in recent years.
In this study, we investigate the effects of ADHD therapeutic drugs and QT prolonging gene polymorphisms on QT interval using a 24 - hour Holter electrocardiogram and establish an assessment method for cardiovascular event risk in children taking ADHD therapeutic drugs.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Difference in prevalence of metabolic syndrome between Japanese outpatients and inpatients with schizophrenia: A nationwide survey2016
Author(s)
Sugai T, Suzuki Y, Yamazaki M, Shimoda K, Mori T, Ozeki Y, Matsuda H, Sugawara N, Yasui-Furukori N, Minami Y, Okamoto K, Sagae T, Someya T
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Journal Title
Schizophrenia research
Volume: 171（1－3）
Issue: 1-3
Pages: 68-73
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] High prevalence of underweight and undernutrition in Japanese inpatients with schizophrenia: a nationwide survey2015
Author(s)
Sugai T, Suzuki Y, Yamazaki M, Shimoda K, Mori T, Ozeki Y, Matsuda H, Sugawara N, Yasui-Furukori N, Minami Y, Okamoto K, Sagae T, Someya T
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Journal Title
BMJ Open
Volume: 5（12）
Issue: 5
Pages: e011619-e011619
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 日本における統合失調症の外来・入院患者間での身体リスクの差異2016
Author(s)
須貝拓朗, 鈴木雄太郎, 山崎學, 下田和孝, 森隆夫, 尾関祐二, 松田ひろし, 岡本呉賦, 寒河江豊昭, 菅原典夫, 古郡規雄, 染矢俊幸
Organizer
第26回日本臨床精神神経薬理学会
Place of Presentation
ホルトホール大分 (大分県大分市）
Year and Date
2016-11-17
Related Report
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[Presentation] High prevalence of underweight and under-nutrition in Japanese inpatients with schizophrenia: A nationwide survey.2016
Author(s)
Sugai T, Suzuki Y, Yamazaki M, Shimoda K, Mori T, Ozeki Y, Matsuda H, Sugawara N, Yasui-Furukori N, Minami Y, Okamoto K, Sagae T, Someya T
Organizer
29th European College of Neuropsychopharmacology Congress
Place of Presentation
Austria Center Vienna (Austria Vienna)
Year and Date
2016-09-17
Related Report
Int'l Joint Research
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