Investigation into the influences of gene x environment interaction on the emergence of ASD-like behavioral tendecy during early development
| Project/Area Number |
26461769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagasaki University |
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Principal Investigator |
DOI Hirokazu 長崎大学, 医歯薬学総合研究科(医学系), 講師 (40437827)
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| Co-Investigator(Kenkyū-buntansha) |
岩永 竜一郎 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (40305389)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOHARA Kazuyuki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (30226154)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ASD / 縦断追跡 / 環境 / 遺伝子 / ダイオキシン / 環境化学物質 / コホート / 脳性分化 / 発達 / 自閉症スペクトラム / 注視点計測 / ジェネラルムーブメント |
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| Outline of Final Research Achievements |
The present study primarily aimed to investigate the influences of gene x environment interaction on the emergence of ASD-like behavioral tendency during early infancy. To achieve this goal, we carried out longitudinal investigation on large cohort of mother-infant pairs, and collected umbilical cord blood samples and the evaluations of ASD-related behavioral tendencies using gaze tracking and questionnaires. Another aim of the present study was to establish an easily-measurable marker of atypical neural function in developmental disorders. The systematic review of fNIRS (functional near-infrared spectroscopy) studies revealed right-lateralization in atypical neural function in children with ADHD, but no consistent pattern was observed in people with ASD.
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Report
(4 results)
Research Products
(3 results)
