Risk factor analysis and building of a therapeutic system for depression after cerebral infarction

• Project/Area Number: 26461774
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokai University
• Principal Investigator: MIKAMI Katsunaka 東海大学, 医学部, 准教授 (90548504)
• Co-Investigator(Kenkyū-buntansha): 水間 敦士 東海大学, 医学部, 助教 (60609311) ; 瀧澤 俊也 東海大学, 医学部, 教授 (70197234) ; 松本 英夫 東海大学, 医学部, 教授 (90199886)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 脳梗塞 / うつ病 / アパシー / うつ

Outline of Final Research Achievements

This study evaluated the frequency and characteristics of adult patients presenting with depression within 6 weeks of cerebral infarction during the first year. In the study, 16.7% of the patients had a diagnosis of depression. A history of psychoactive drug usage was more frequent in the depression group. Moreover, the scores on either a self-administered or an objective questionnaire used during the acute phase of cerebral infarction were higher in the depression group. A history of psychotropic drug use might be a risk factor for depression after cerebral infarction. In addition, the evaluation of a depressive state in the acute period of cerebral infarction might be a predictive factor for depression within the first year.

Research Products

• [Presentation] Frequency and risk-related factors of post-stroke depression during the first year (2017)
  • Author(s): Keitaro Kimoto, Katsunaka Mikami, Takeshi Sudo, Natsuru Watanabe, Fumiaki Akama, Tsuyoshi Uesugi, Reina Kawamura, Atsushi Mizuma,Eiichiro Nagata , Shunya Takizawa, Hideo Matsumoto, Kenji Yamamoto
  • Organizer: World Psychiatric Association
  • Int'l Joint Research
• [Presentation] 脳梗塞後アパシーの頻度と特徴 (2017)
  • Author(s): 木本啓太郎、三上克央、渡邉己弦、須藤武司、岩本美知代、川村玲衣奈、植杉剛、永田栄一郎、山本賢司、瀧澤俊也、松本英夫
  • Organizer: 第30回日本総合病院精神医学会総会
• [Presentation] 脳梗塞後うつの追跡研究 (2016)
  • Author(s): 木本啓太郎、水間敦士、三上克央、植杉剛、高地真以子、祢津静花、川村玲衣奈、須藤武司、滝澤毅矢、岩本美知代、渡邉己弦、風張昌司、松本英夫、山本賢司、永田栄一郎、瀧澤俊也
  • Organizer: 第29回日本総合病院精神医学会総会
  • Place of Presentation: 日本教育会館、東京都千代田区
  • Year and Date: 2016-11-25
• [Presentation] Influence of poststroke apathy on physical and cognitive function. Symposium “Neuropsychiatric disorders and management of stroke” (2016)
  • Author(s): Katsunaka Mikami
  • Organizer: 17th Pacific Rim College of Psychiatrists Scientific Meeting
  • Place of Presentation: Kaohsiung Exhibition Center, Kaohsiung, Taiwan
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] Role of selective serotonin-reuptake inhibitors as an adjunctive treatment to physical recovery after stroke. Symposium “Depression, Self-Efficacy, and Antidepressant in Stroke” (2016)
  • Author(s): Katsunaka Mikami
  • Organizer: 2016 International RANZCP (The Royal Australian and New Zealand College of Psychiatrists) Congress of Psychiatry
  • Place of Presentation: Hong Kong Convention Centre, Hong Kong
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] Advantages and Disadvantages of Antidepressants for Recent Poststroke Patients. Symposium “Neuropsychiatry in Stroke” (2015)
  • Author(s): Katsunaka Mikami
  • Organizer: World Psychiatry Association International Congress of Psychiatry
  • Place of Presentation: Taipei International Convention Center, Taipei, Taiwan
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Physical Recovery after Stroke Using Antidepressants. Symposium “Neuropsychiatry in Stroke.” (2014)
  • Author(s): Katsunaka Mikami.
  • Organizer: World Psychiatry Association Regional Congress.
  • Place of Presentation: Hong Kong
  • Year and Date: 2014-12-12 – 2014-12-14