| Project/Area Number |
26461782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大倉 一枝 北海道医療大学, 薬学部, 教授 (60094827)
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| Co-Investigator(Renkei-kenkyūsha) |
KUGE YUJI 北海道大学, アイソトープ総合センター, 教授 (70321958)
ZHAO SONGJI 福島県立医科大学, 福島国際医療科学センター, 教授 (80374239)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 放射性薬剤 / 癌 / チミジンホスホリラーゼ / 放射性診断薬剤 / 血管新生 / 自動合成 |
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| Outline of Final Research Achievements |
The angiogenic factor PD-ECGF/ Thymidine phosphorylase (TP) is expressed at a high level in various solid tumors as compared with the normal tissue. In this study, we aimed to construct an automated manufacturing system for I-123 labeled IIMU that we have developed imaging targeting for PD-ECGF. During this research period, the solution composition of radioactive iodine as a raw material was changed. Therefore, we had to optimize the synthetic condition of I-123 labeled IIMU again. The results of study, it was possible to give I-123 labeled IIMU with the same radiochemical yield as conventional methods. The results of this research gave important knowledge for the automated manufacturing system of the I-123 labeled IIMU.
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