Quantification of breast cancer microenvironment by three dimensional integration of micro bubble contrast ultrasound and MRI image

Research Project

Project/Area Number	26461783
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	Takasawa Chiaki 東北大学, 医学系研究科, 非常勤講師 (60623189)
Co-Investigator(Kenkyū-buntansha)	森菜緒子東北大学, 大学病院, 助教 (90535064) 高瀬圭東北大学, 医学系研究科, 教授 (60361094) 小玉哲也東北大学, 医工学研究科, 教授 (40271986) 石田孝宣東北大学, 医学系研究科, 准教授 (00292318) 宮下穣東北大学, 大学病院, 助教 (60710788)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	乳癌 / 血管密度 / 造影超音波 / 定量解析 / マイクロバブル / 拡散強調画像 / 造影超音波定量解析
Outline of Final Research Achievements	The quantitative method of contrast ultrasound is currently equipped with time intensity curve analysis in clinical models. Peak intensity and area under the curve are calculated as parameters, and it is reported that these correlate with MVD. As a new method, we focus on a certain pixel, measure how the color of pixel changes in the time axis direction, divide one with a large degree of change and one with a small change by threshold．We developed a method to detect things as detected pixels of the contrast agent. Finally, an area ratio (enhancement area ratio) of the region where the contrast medium is detected is calculated with respect to the region of interest. In this study, we clarified that the enhancement area ratio correlates with the pathological MVD of invasive cancer.