| Project/Area Number |
26461783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
Takasawa Chiaki 東北大学, 医学系研究科, 非常勤講師 (60623189)
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| Co-Investigator(Kenkyū-buntansha) |
森 菜緒子 東北大学, 大学病院, 助教 (90535064)
高瀬 圭 東北大学, 医学系研究科, 教授 (60361094)
小玉 哲也 東北大学, 医工学研究科, 教授 (40271986)
石田 孝宣 東北大学, 医学系研究科, 准教授 (00292318)
宮下 穣 東北大学, 大学病院, 助教 (60710788)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 乳癌 / 血管密度 / 造影超音波 / 定量解析 / マイクロバブル / 拡散強調画像 / 造影超音波定量解析 |
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| Outline of Final Research Achievements |
The quantitative method of contrast ultrasound is currently equipped with time intensity curve analysis in clinical models. Peak intensity and area under the curve are calculated as parameters, and it is reported that these correlate with MVD. As a new method, we focus on a certain pixel, measure how the color of pixel changes in the time axis direction, divide one with a large degree of change and one with a small change by threshold．We developed a method to detect things as detected pixels of the contrast agent. Finally, an area ratio (enhancement area ratio) of the region where the contrast medium is detected is calculated with respect to the region of interest. In this study, we clarified that the enhancement area ratio correlates with the pathological MVD of invasive cancer.
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