Development of evaluation method for myocardial tissue characterization in patients with ischemic heart disease by using MOLLI MR images on 3T MR scanner.

• Project/Area Number: 26461787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: NAGATA MOTONORI 三重大学, 医学部附属病院, 助教 (40402028)
• Co-Investigator(Kenkyū-buntansha): 石田 正樹 三重大学, 医学部附属病院, 助教 (10456741) ; 佐久間 肇 三重大学, 医学系研究科, 教授 (60205797)
• Co-Investigator(Renkei-kenkyūsha): YOSHITAKA Goto 三重大学, 医学部附属病院, 医員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: T1マッピング / MOLLI MRI / 細胞外液分画 / 心筋梗塞 / 心筋性状 / 心臓MRI / 心筋T1値 / 細胞外分画 / 虚血性心疾患 / T1マップ / 線維組織

Outline of Final Research Achievements

Rapid innovations in cardiovascular magnetic resonance now permit the routine acquisition of quantitative measures of myocardial T1 which is key tissue characteristics.
We studied its usefulness mainly in patients with ischemic heart disease. As a result, it was shown that in patients with acute myocardial infarction, the extracellular volume fraction and native myocardial T1 are significantly elevated even in non-infarcted myocardium, which is caused by a strong ischemic event following to infarction. In addition, it was shown that the extracellular volume fraction and native myocardial T1 correlate well with the histological fibrosis index. Furthermore, in comparison with late gadolinium enhancement MRI, which is considered to be a gold standard for the non-invasive assessment of myocardial infarction, the non-contrast myocardial T1 could detect myocardial infarction with high accuracy.

Research Products

• [Presentation] he association between coronary flow reserve, extracellular volume fraction and left ventricular function in patients with non-ischemic dilated cardiomyopathy (2017)
  • Author(s): Yoshitaka Goto, Masaki Ishida, Akimasa Yamada, Mio Uno, Wakana Makino, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Hajime Sakuma
  • Organizer: 20th Annual SCMR Scientific Sessions
  • Place of Presentation: Washington, DC (USA)
  • Year and Date: 2017-02-03
  • Int'l Joint Research
• [Presentation] Native T1 mapping allows for the accurate detection of the segments with myocardial infarction in patients with suspected coronary artery disease. (2016)
  • Author(s): Yoshitaka Goto, Masaki Ishida, Akimasa Yamada, Mio Uno, Shiro Nakamori, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Kaoru Dohi, Masaaki Ito, Hajime Sakuma
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2016-04-15
• [Presentation] Native T1 mapping allows for the accurate detection of the segments with chronic myocardial infarction in patients with known or suspected coronary artery disease. (2016)
  • Author(s): Yoshitaka Goto, Masaki Ishida, Akimasa Yamada, Mio Uno, Shiro Nakamori, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Kaoru Dohi, Masaaki Ito, Hajime Sakuma
  • Organizer: Society for Cardiovascular Magnetic Resonance
  • Place of Presentation: ロサンゼルス（米国）
  • Year and Date: 2016-01-27
  • Int'l Joint Research