Biomarker and CT volumetry for the evaluation of NSCLC after chemotherapy
| Project/Area Number |
26461790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梁川 雅弘 大阪大学, 医学系研究科, 助教 (00546872)
本多 修 大阪大学, 医学系研究科, 講師 (80324755)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 非小細胞肺癌 / 治療効果判定法 / マルチスライスＣＴ / ＲＥＣＩＳＴ / 三次元的体積測定法 / ボリュームデータ / マルチスライスCT / RECIST |
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| Outline of Final Research Achievements |
Our study aimed to calculate the volume of pulmonary nodule in a patient with non-small cell lung cancer (NSCLC) by using CT volumetry with volume data obtained by MDCT and to investigate its usefulness for the evaluation of treatment response of NSCLC after chemotherapy. CT images of all nodules were reconstructed with a slice thickness of 0.5 mm or 0.625 mm. All CT data were transferred to 3D workstation through PACS and nodule volumes were calculated using CT volumetric software by three radiologists. Dual energy technique was applied in some cases and blood supply in the nodules was quantified using contrast material information. CT volumetry was confirmed to be reproducible and reliable for the evaluation of treatment response of NSCLC after chemotherapy. Dual energy technique gave additional information in relation to some gene expressions of NSCLC.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Prognostic Importance of Volumetric Measurements in Stage I Lung Adenocarcinoma.2014
Author(s)
Yanagawa M, Tanaka Y, Leung AN, Morii E, Kusumoto M, Watanabe S, Watanabe H, Inoue M, Okumura M, Gyobu T, Ueda K, Honda O, Sumikawa H, Johkoh T, Tomiyama N.
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Journal Title
Radiology
Volume: 272
Pages: 557-67
Related Report
Peer Reviewed
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[Presentation] Radiological Prediction About Tumor Invasiveness of Lung Adenocarcinoma on High Resolution CT.2015
Author(s)
Yanagawa M, Johkoh T, Noguchi M, Morii E, Ueda K, Masada M, Gyobu T, Hata A, Honda O, Tomiyama N.
Organizer
Radiological Society of North America 101th Scientific Assembly and Annual Meeting.
Place of Presentation
Chicago, U.S.A.
Year and Date
2015-11-29
Related Report
Int'l Joint Research
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[Presentation] The latest Imaging Assessment for Anti-Tumor Therapy: therapeutic response for various tumors using PET/CT or PET/MRI.2014
Author(s)
Yanagawa M, Watabe T, Isohashi K, Honda O, Ueda K, Sumikawa H, Satoh Y, Kanazawa T, Hidaka S, Masada M, Hatazawa J, Tomiyama N.
Organizer
Radiological Society of North America 100th Scientific Assembly and Annual Meeting.
Place of Presentation
Chicago, U.S.A.
Year and Date
2014-11-30 – 2014-12-05
Related Report
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[Presentation] Quantitative Evaluation of Tumor Invasiveness in Non-Mucinous Adenocarcinoma.2014
Author(s)
Yanagawa M, Johkoh T, Noguchi M, Morii E, Ueda K, Fujiwara M, Kanazawa T, Hidaka S, Honda O, Tomiyama N.
Organizer
The 15th Asian Oceanian Congress of Radiology.
Place of Presentation
Kobe, Japan
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] PET using H215O in non-small cell lung cancer: quantitative evaluation of antiangiogenic therapy effects.2014
Author(s)
Yanagawa M, Matsunaga K, Watabe H, Shimoegawa E, Fujino K, Kato H, Ueda K, Sato Y, Kanazawa T, Hidaka S, Sumikawa H, Honda O, Kijima T, Hatazawa J, Tomiyama N.
Organizer
The 73nd Annual Meeting of the Japan Radiological Society.
Place of Presentation
Yokohama, Japan
Year and Date
2014-04-10 – 2014-04-13
Related Report
