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Biomarker and CT volumetry for the evaluation of NSCLC after chemotherapy

Research Project

Project/Area Number 26461790
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

NORIYUKI TOMIYAMA  大阪大学, 医学系研究科, 教授 (50294070)

Co-Investigator(Kenkyū-buntansha) 梁川 雅弘  大阪大学, 医学系研究科, 助教 (00546872)
本多 修  大阪大学, 医学系研究科, 講師 (80324755)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords非小細胞肺癌 / 治療効果判定法 / マルチスライスCT / RECIST / 三次元的体積測定法 / ボリュームデータ / マルチスライスCT / RECIST
Outline of Final Research Achievements

Our study aimed to calculate the volume of pulmonary nodule in a patient with non-small cell lung cancer (NSCLC) by using CT volumetry with volume data obtained by MDCT and to investigate its usefulness for the evaluation of treatment response of NSCLC after chemotherapy. CT images of all nodules were reconstructed with a slice thickness of 0.5 mm or 0.625 mm. All CT data were transferred to 3D workstation through PACS and nodule volumes were calculated using CT volumetric software by three radiologists. Dual energy technique was applied in some cases and blood supply in the nodules was quantified using contrast material information. CT volumetry was confirmed to be reproducible and reliable for the evaluation of treatment response of NSCLC after chemotherapy. Dual energy technique gave additional information in relation to some gene expressions of NSCLC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Prognostic Importance of Volumetric Measurements in Stage I Lung Adenocarcinoma.2014

    • Author(s)
      Yanagawa M, Tanaka Y, Leung AN, Morii E, Kusumoto M, Watanabe S, Watanabe H, Inoue M, Okumura M, Gyobu T, Ueda K, Honda O, Sumikawa H, Johkoh T, Tomiyama N.
    • Journal Title

      Radiology

      Volume: 272 Pages: 557-67

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Quantification of Pulmonary Nodule: Prediction of Malignancy and Prognosis.2016

    • Author(s)
      Yanagawa M, Honda O, Kikuchi N, Hata A, Tomiyama N.
    • Organizer
      Radiological Society of North America 102th Scientific Assembly and Annual Meeting.
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Radiological Prediction About Tumor Invasiveness of Lung Adenocarcinoma on High Resolution CT.2015

    • Author(s)
      Yanagawa M, Johkoh T, Noguchi M, Morii E, Ueda K, Masada M, Gyobu T, Hata A, Honda O, Tomiyama N.
    • Organizer
      Radiological Society of North America 101th Scientific Assembly and Annual Meeting.
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2015-11-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「肺癌の画像診断を再考する-MDCTとPET/CTの時代―」 肺腺癌国際新分類のCT画像:形態学的評価から定量的評 価2015

    • Author(s)
      梁川雅弘
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 「肺癌の画像診断Updata:見る、観る、診る」2015

    • Author(s)
      梁川 雅弘
    • Organizer
      第18回関西 Radiology Update 講演会
    • Place of Presentation
      大阪
    • Year and Date
      2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] The latest Imaging Assessment for Anti-Tumor Therapy: therapeutic response for various tumors using PET/CT or PET/MRI.2014

    • Author(s)
      Yanagawa M, Watabe T, Isohashi K, Honda O, Ueda K, Sumikawa H, Satoh Y, Kanazawa T, Hidaka S, Masada M, Hatazawa J, Tomiyama N.
    • Organizer
      Radiological Society of North America 100th Scientific Assembly and Annual Meeting.
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2014-11-30 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺腺癌新国際分類に基づいた肺結節内のCT値分布の定量解析2014

    • Author(s)
      梁川雅弘、上甲剛、野口雅之 、新谷康 、奥村明之進 、本多修 、富山憲幸
    • Organizer
      第55回日本肺癌学会学術集会 画像診断 教育講演2 肺縦隔
    • Place of Presentation
      京都
    • Year and Date
      2014-11-14 – 2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Approach to pulmonary nodule: Importance of follow up CT.2014

    • Author(s)
      Honda O.
    • Organizer
      SMC-Osaka University Radiology Forum.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 胸部腫瘍性病変の画像診断:肺腺癌、胸腺腫を中心に2014

    • Author(s)
      梁川雅弘
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] アスペルギルス感染を合併した両側肺腺癌の一例2014

    • Author(s)
      藤原万貴、坪井真悠子、日髙正二朗、上田賢、金澤達、梁川雅弘、本多修、南正人、森井英一、富山憲幸
    • Organizer
      第28回胸部放射線研究会
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Quantitative Evaluation of Tumor Invasiveness in Non-Mucinous Adenocarcinoma.2014

    • Author(s)
      Yanagawa M, Johkoh T, Noguchi M, Morii E, Ueda K, Fujiwara M, Kanazawa T, Hidaka S, Honda O, Tomiyama N.
    • Organizer
      The 15th Asian Oceanian Congress of Radiology.
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2014-09-24 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 微小肺結節を発見したら:診断、Follow-up、Volumetric CT dataの活用について2014

    • Author(s)
      梁川雅弘
    • Organizer
      第26回九州臨床画像解析研究会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] PET using H215O in non-small cell lung cancer: quantitative evaluation of antiangiogenic therapy effects.2014

    • Author(s)
      Yanagawa M, Matsunaga K, Watabe H, Shimoegawa E, Fujino K, Kato H, Ueda K, Sato Y, Kanazawa T, Hidaka S, Sumikawa H, Honda O, Kijima T, Hatazawa J, Tomiyama N.
    • Organizer
      The 73nd Annual Meeting of the Japan Radiological Society.
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-04-10 – 2014-04-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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