Biomarker and CT volumetry for the evaluation of NSCLC after chemotherapy

• Project/Area Number: 26461790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: NORIYUKI TOMIYAMA 大阪大学, 医学系研究科, 教授 (50294070)
• Co-Investigator(Kenkyū-buntansha): 梁川 雅弘 大阪大学, 医学系研究科, 助教 (00546872) ; 本多 修 大阪大学, 医学系研究科, 講師 (80324755)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 非小細胞肺癌 / 治療効果判定法 / マルチスライスＣＴ / ＲＥＣＩＳＴ / 三次元的体積測定法 / ボリュームデータ / マルチスライスCT / RECIST

Outline of Final Research Achievements

Our study aimed to calculate the volume of pulmonary nodule in a patient with non-small cell lung cancer (NSCLC) by using CT volumetry with volume data obtained by MDCT and to investigate its usefulness for the evaluation of treatment response of NSCLC after chemotherapy. CT images of all nodules were reconstructed with a slice thickness of 0.5 mm or 0.625 mm. All CT data were transferred to 3D workstation through PACS and nodule volumes were calculated using CT volumetric software by three radiologists. Dual energy technique was applied in some cases and blood supply in the nodules was quantified using contrast material information. CT volumetry was confirmed to be reproducible and reliable for the evaluation of treatment response of NSCLC after chemotherapy. Dual energy technique gave additional information in relation to some gene expressions of NSCLC.

Research Products

• [Journal Article] Prognostic Importance of Volumetric Measurements in Stage I Lung Adenocarcinoma. (2014)
  • Author(s): Yanagawa M, Tanaka Y, Leung AN, Morii E, Kusumoto M, Watanabe S, Watanabe H, Inoue M, Okumura M, Gyobu T, Ueda K, Honda O, Sumikawa H, Johkoh T, Tomiyama N.
  • Journal Title: Radiology Volume: 272 Pages: 557-67
  • Peer Reviewed
• [Presentation] Quantification of Pulmonary Nodule: Prediction of Malignancy and Prognosis. (2016)
  • Author(s): Yanagawa M, Honda O, Kikuchi N, Hata A, Tomiyama N.
  • Organizer: Radiological Society of North America 102th Scientific Assembly and Annual Meeting.
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2016-11-27
• [Presentation] Radiological Prediction About Tumor Invasiveness of Lung Adenocarcinoma on High Resolution CT. (2015)
  • Author(s): Yanagawa M, Johkoh T, Noguchi M, Morii E, Ueda K, Masada M, Gyobu T, Hata A, Honda O, Tomiyama N.
  • Organizer: Radiological Society of North America 101th Scientific Assembly and Annual Meeting.
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] 「肺癌の画像診断を再考する－MDCTとPET/CTの時代―」 肺腺癌国際新分類のCT画像：形態学的評価から定量的評 価 (2015)
  • Author(s): 梁川雅弘
  • Organizer: 第56回日本肺癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-11-14
• [Presentation] 「肺癌の画像診断Updata：見る、観る、診る」 (2015)
  • Author(s): 梁川 雅弘
  • Organizer: 第18回関西 Radiology Update 講演会
  • Place of Presentation: 大阪
  • Year and Date: 2015-03-14
• [Presentation] The latest Imaging Assessment for Anti-Tumor Therapy: therapeutic response for various tumors using PET/CT or PET/MRI. (2014)
  • Author(s): Yanagawa M, Watabe T, Isohashi K, Honda O, Ueda K, Sumikawa H, Satoh Y, Kanazawa T, Hidaka S, Masada M, Hatazawa J, Tomiyama N.
  • Organizer: Radiological Society of North America 100th Scientific Assembly and Annual Meeting.
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] 肺腺癌新国際分類に基づいた肺結節内のCT値分布の定量解析 (2014)
  • Author(s): 梁川雅弘、上甲剛、野口雅之 、新谷康 、奥村明之進 、本多修 、富山憲幸
  • Organizer: 第55回日本肺癌学会学術集会 画像診断 教育講演2 肺縦隔
  • Place of Presentation: 京都
  • Year and Date: 2014-11-14 – 2014-11-15
• [Presentation] Approach to pulmonary nodule: Importance of follow up CT. (2014)
  • Author(s): Honda O.
  • Organizer: SMC-Osaka University Radiology Forum.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] 胸部腫瘍性病変の画像診断：肺腺癌、胸腺腫を中心に (2014)
  • Author(s): 梁川雅弘
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-07 – 2014-11-08
• [Presentation] アスペルギルス感染を合併した両側肺腺癌の一例 (2014)
  • Author(s): 藤原万貴、坪井真悠子、日髙正二朗、上田賢、金澤達、梁川雅弘、本多修、南正人、森井英一、富山憲幸
  • Organizer: 第28回胸部放射線研究会
  • Place of Presentation: 神戸
  • Year and Date: 2014-09-26
• [Presentation] Quantitative Evaluation of Tumor Invasiveness in Non-Mucinous Adenocarcinoma. (2014)
  • Author(s): Yanagawa M, Johkoh T, Noguchi M, Morii E, Ueda K, Fujiwara M, Kanazawa T, Hidaka S, Honda O, Tomiyama N.
  • Organizer: The 15th Asian Oceanian Congress of Radiology.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] 微小肺結節を発見したら：診断、Follow-up、Volumetric CT dataの活用について (2014)
  • Author(s): 梁川雅弘
  • Organizer: 第26回九州臨床画像解析研究会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-23
• [Presentation] PET using H215O in non-small cell lung cancer: quantitative evaluation of antiangiogenic therapy effects. (2014)
  • Author(s): Yanagawa M, Matsunaga K, Watabe H, Shimoegawa E, Fujino K, Kato H, Ueda K, Sato Y, Kanazawa T, Hidaka S, Sumikawa H, Honda O, Kijima T, Hatazawa J, Tomiyama N.
  • Organizer: The 73nd Annual Meeting of the Japan Radiological Society.
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2014-04-10 – 2014-04-13