Evaluation of a proper cutoff value on quantitative dual-energy perfusion CT for the assessment of acute pulmonary thromboembolism

• Project/Area Number: 26461794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yamaguchi University
• Principal Investigator: KUNIHIRO Yoshie 山口大学, 医学部, 特別医学研究員 (30448310)
• Co-Investigator(Kenkyū-buntansha): 松永 尚文 山口大学, 医学(系)研究科(研究院), 教授 (40157334) ; 岡田 宗正 山口大学, 医学部附属病院, 准教授 (70380003)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: dual-energy CT

Outline of Final Research Achievements

Dual-energy perfusion computed tomography (DEpCT) images were three-dimensionally reconstructed at the following attenuation ranges: 1-2 HU (V2) to 1-10 HU (V10), and 1-120 HU (V120). The ratios of low perfusion areas associated with each threshold range per V120 were also calculated, and the relative ratios were expressed as %V2 to %V10. These values were compared with factors indicating the severity of acute pulmonary thromboembolism (PTE), including the pulmonary arterial pressure, heart rate, CT angiographic obstruction index (CTOI), and right/left ventricular diameter ratio (RV/LV).
The area under the curve (AUC) of %V2 was highest (0.783) among these values based on the presence of intrapulmonary clots. The %V2 showed moderate correlations with CTOI (r=0.36, p=0.005) and RV/LV (r=0.36, p=0.004) in the patients with acute PTE. %V2 exhibit the best correlation with factors suggesting the severity of acute PTE.

Research Products

• [Journal Article] Evaluation of a proper cutoff value on quantitative dual-energy perfusion CT for the assessment of acute pulmonary thromboembolism (2017)
  • Author(s): Yoshie Kunihiro, Munemasa Okada
  • Journal Title: Acta Radiologica Volume: 印刷中 Issue: 9 Pages: 1061-1067
  • DOI: 10.1177/0284185116683577
  • Peer Reviewed
• [Journal Article] Added value of lung perfused blood volume images using dual-energy CT for assessment of acute pulmonary embolism. (2015)
  • Author(s): Okada M, Kunihiro Y, Nakashima Y, Nomura T, Kudomi S, Yonezawa T, Suga K, Matsunaga N.
  • Journal Title: Eur J Radiol Volume: 84 Issue: 1 Pages: 172-7
  • DOI: 10.1016/j.ejrad.2014.09.009
  • Peer Reviewed
• [Journal Article] Pulmonary emphysema on dyal-energy perfusion CT: assessment with pulmonary functional tests and lung CT (2014)
  • Author(s): Yoshie Kunihiro, Munemasa Okada, Yoshiteru Nakashima, Naofumi Matsunaga
  • Journal Title: Japanese Journal of Diagnostic Imaging Volume: 32 Pages: 109-118
  • Peer Reviewed
• [Presentation] The assessment of proper cut-off value for the severity of acute pulmonary embolism (2015)
  • Author(s): Yoshie Kunihiro, Munemasa Okada, Yoshiteru Nakashima, Takafumi Nomura, Sei Nakao, Naofumi Matsunaga
  • Organizer: 第51回日本医学放射線学会秋季臨床大会
  • Place of Presentation: アイーナ、マリオス（岩手県盛岡市）
  • Year and Date: 2015-10-02
• [Presentation] Added value of dual-energy perfusion CT for the evaluation of intrapulmonary clots using 64-slice dual-source CT (2014)
  • Author(s): Munemasa Okada, Yoshie Kunihiro, Yoshiteru Nakashima, Takafumi Nomura, Teppei Yonezawa, Shohei Kudomi, Yuichi Sano, Kazuyoshi Suga, Naofumi Matsunaga
  • Organizer: The 73rd annual Meeting of the Japan Radiological Society
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13