| Project/Area Number |
26461794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松永 尚文 山口大学, 医学(系)研究科(研究院), 教授 (40157334)
岡田 宗正 山口大学, 医学部附属病院, 准教授 (70380003)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | dual-energy CT |
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| Outline of Final Research Achievements |
Dual-energy perfusion computed tomography (DEpCT) images were three-dimensionally reconstructed at the following attenuation ranges: 1-2 HU (V2) to 1-10 HU (V10), and 1-120 HU (V120). The ratios of low perfusion areas associated with each threshold range per V120 were also calculated, and the relative ratios were expressed as %V2 to %V10. These values were compared with factors indicating the severity of acute pulmonary thromboembolism (PTE), including the pulmonary arterial pressure, heart rate, CT angiographic obstruction index (CTOI), and right/left ventricular diameter ratio (RV/LV).
The area under the curve (AUC) of %V2 was highest (0.783) among these values based on the presence of intrapulmonary clots. The %V2 showed moderate correlations with CTOI (r=0.36, p=0.005) and RV/LV (r=0.36, p=0.004) in the patients with acute PTE. %V2 exhibit the best correlation with factors suggesting the severity of acute PTE.
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