Virtual CT biopsy techniue for no invasive diagnosis of tissue component
| Project/Area Number |
26461808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University (2017-2018)
Kindai University (2014-2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鶴崎 正勝 近畿大学, 医学部附属病院, 准教授 (00379356)
兵頭 朋子 近畿大学, 医学部, 講師 (40403836)
祖父江 慶太郎 神戸大学, 医学部附属病院, 講師 (90622027)
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Dual energy CT / 肝生検 / 脂肪 / ヨード / 肝線維化 / 複合物質分別処理技術 / シスプラチン / 肝繊維化 / Material Decomposition |
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| Outline of Final Research Achievements |
Dual Energy CT (DECT) has the potential to distinguish between certain substances according to changes in their X-absorption values, using x-ray data consisting of different energies. In this study, we developed multi-material decomposition technology (MMD: Multi Material Decomposition) using DECT that can quantitatively measure the amount of a specific substance in liver cirrhosis, fatty liver and NASH, and that of drug administered in lesions. Thus, we devised a method of virtual liver CT biopsy, a non-invasive early liver diagnosis technology which can quantitatively diagnose liver fat deposition and fibrosis in relation to the risk of hepatocellular carcinoma, as well as monitor the amount of anticancer agents, such as cisplatin, that have reached the tumor.
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| Academic Significance and Societal Importance of the Research Achievements |
非アルコール性脂肪肝炎（NASH）は肝硬変に進行する可能性をあり、肝細胞癌発生のリスクが高くなる。特に経過中に起こる肝の線維化の程度が肝細胞癌の発生リスクに関係することが知られている為、脂肪沈着や肝の線維化の早期診断や治療効果の判定は重要である。しかし、確定診断には侵襲的な肝生検が必須であった。本研究のDual Energy CTによる複合物質分別処理技術は低侵襲検査であり、重症度の高い患者さんにも適応でき、外来でも行える患者さんの身体的、経済的負担の非常に少ない検査である。NASHの高危険群を囲い込み、早期に適切な治療を行うことによって、肝疾患関連死を抑制できることが期待される。
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Report
(6 results)
Research Products
(24 results)
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[Journal Article] Dual-energy computed tomography for non-invasive staging of liver fibrosis: Accuracy of iodine density measurements from contrast-enhanced data.2018
Author(s)
Sofue K, Tsurusaki M, Mileto A, Hyodo T, Sasaki K, Nishi T, Chikugo T, Yada N, Kudo M, Sugimura K, Murakami T
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Journal Title
Hepatol Res
Volume: 48(12)
Issue: 12
Pages: 1008-1019
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Magnetic resonance elastography in the assessment of hepatic fibrosis: a study comparing transient elastography and histological data in the same patients.2017
Author(s)
Toguchi M, Tsurusaki M, Yada N, Sofue K, Hyodo T, Onoda M, Numoto I, Matsuki M, Imaoka I, Kudo M, Murakami T.
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Journal Title
Abdom Radiol
Volume: 42
Issue: 6
Pages: 1659-1666
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of elemental weight fraction and mass density of humanoid tissue-equivalent materials using dual energy computed tomography2017
Author(s)
Kohei Shimomura, Fujio Araki, Fujio ArakiEmail the author Fujio Araki, Yuki Kono, Yoshiyuki Asai, Takamichi Murakami, Tomoko Hyodo, Masahiko Okumura, Kenji Matsumoto, Hajime Monzen, Yasumasa Nishimura
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Journal Title
Physica Medica: European Journal of Medical Physics
Volume: 39
Pages: 59-66
DOI
Related Report
Peer Reviewed / Open Access
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