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Studies on PET Imaging of Cancer Using Cu-64 Ions

Research Project

Project/Area Number 26461812
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology (2016)
Japan Atomic Energy Agency (2014-2015)

Principal Investigator

SUGO Yumi  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員(定常) (90354836)

Co-Investigator(Kenkyū-buntansha) 大島 康宏  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主任研究員(定常) (00588676)
Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI Aiko  群馬大学, 大学院医学系研究科・寄附講座, 教員 (80609032)
HANAOKA Hirofumi  群馬大学, 大学院医学系研究科, 特任准教授 (50361390)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCu-64 / がん / PETイメージング / がん細胞 / 体内動態
Outline of Final Research Achievements

Copper-64 (Cu-64) is an attractive radionuclide for positron emission tomography (PET) imaging due to its appropriate half-life and decay characteristics. We proposed a new approach to simplified method for PET imaging of cancer using Cu-64 ions without any labeling process.
In this study the usefulness of Cu-64 ions as a PET imaging agent was evaluated. It was demonstrated that the cancer was successfully visualized on the PET images owing to quite high uptake of Cu-64 in the cancer tissue.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Application of 67Cu Produced by 68Zn(n,n'p+d)67Cu to Biodistribution Study in Tumor-Bearing Mice2017

    • Author(s)
      Y. Sugo, K. Hashimoto, M. Kawabata, H. Saeki, S. Sato, K. Tsukada, and Y. Nagai
    • Journal Title

      J. Phys. Soc. Jpn.

      Volume: 86 Issue: 2 Pages: 023201-023201

    • DOI

      10.7566/jpsj.86.023201

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In vitro Studies on Cellular Binding and Stability of 64Cu-Labeled Peptide for Tumor Imaging2015

    • Author(s)
      Y. Sugo, Y. Ohshima, I. Sasaki, and N. S. Ishioka
    • Journal Title

      Peptide Science 2014

      Volume: - Pages: 303-306

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] サイクロトロンで製造する放射性銅のがんの診断・治療への応用2016

    • Author(s)
      須郷由美、大島康宏、山口藍子、花岡宏史、塚田和明、橋本和幸、川端方子、佐伯秀也、永井泰樹、石岡典子
    • Organizer
      第59回放射線化学討論会
    • Place of Presentation
      高崎量子応用研究所(群馬県・高崎市)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cu-64イオンを用いたがんのPETイメージング2015

    • Author(s)
      須郷由美、大島康宏、山口藍子、花岡宏史、石岡典子
    • Organizer
      2015放射化学会年会・第59回放射化学討論会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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