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The accuracy of new diagnostic modality for the diagnosis of colorectal tumors

Research Project

Project/Area Number 26461815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

Kakugawa Yasuo  国立研究開発法人国立がん研究センター, 中央病院, 医長 (00537889)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords大腸カプセル内視鏡 / 感度 / 平坦型腫瘍 / CTコロノグラフィー(大腸3D-CT) / 大腸腫瘍 / 大腸がん検診
Outline of Final Research Achievements

We conducted a multicenter study to clarify the accuracy of colon capsule endoscopy as new diagnostic modality for the diagnosis of colorectal tumors (in particular, flat or depressed lesions). In this study, colon capsule endoscopy was shown to have 94% sensitivity (62/66). The relative sensitivity of colon capsule endoscopy compared to traditional total colonoscopy was 1.43 (165/115) in protruded lesion and 1.58 (82/52) in flat or depressed lesion. Then, we investigated the detection rate of colorectal lesions using dual camera devices equipped by colon capsule endoscopy in comparison with theological single camera devices. The dual camera increased the detection rate for flat or depressed lesion by a factor of 1.6-1.8 times higher when compared to a theological single camera. Our study revealed that colon capsule endoscopy has enough sensitivity for use in patients suspected of having flat or depressed lesions.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (39 results)

All 2017 2016 2015 2014

All Journal Article (26 results) (of which Peer Reviewed: 9 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening. World journal of gastroenterology2017

    • Author(s)
      Sekiguchi M, Terauchi T, Kakugawa Y, Shimada N, Saito Y, Matsuda T.
    • Journal Title

      WJG

      Volume: 23 Pages: 2473-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regional colorectal cancer screening program using colonoscopy on an island: a prospective Nii-jima study.2017

    • Author(s)
      Hotta K, Matsuda T, Kakugawa Y, Ikematsu H, Kobayashi N, Kushima R, Hozawa A, Nakajima T, Sakamoto T, Mori M, Fujii T, Saito Y
    • Journal Title

      Japanese journal of clinical oncology

      Volume: 47 Pages: 118-22

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Colorectal cancer prevention and early diagnosis using endoscopy.2016

    • Author(s)
      Matsuda T, Sekiguchi M, Kakugawa Y, Ikematsu H, Oono Y, Chiu HM, Sano Y, Fujii T, Saito Y.
    • Journal Title

      The Japanese journal of gastro-enterology

      Volume: 113 Pages: 1176-85

    • NAID

      130005162985

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensitivity of 2-[18F]fluoro-2-deoxyglucose positron emission tomography for advanced colorectal neoplasms: a large-scale analysis of 7505 asymptomatic screening individuals.2016

    • Author(s)
      Sekiguchi M, Kakugawa Y, Terauchi T, Matsumoto M, Saito H, Muramatsu Y, Saito Y, Matsuda T
    • Journal Title

      Journal of gastroenterology

      Volume: 51 Pages: 1122-32

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual camera colon capsule endoscopy increases detection of colorectal lesions.2016

    • Author(s)
      Takamaru H, Yamada M, Sakamoto T, Nakajima T, Saito Y, Kakugawa Y, Matsumoto M, Matsuda T, Ide D, Saito S, Gulati S, Tajiri H.
    • Journal Title

      Scandinavian journal of gastroenterology

      Volume: 51 Pages: 1532-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surveillance using capsule endoscopy is safe in post-colectomy patients with familial adenomatous polyposis: a prospective Japanese study.2016

    • Author(s)
      Matsumoto M, Nakajima T, Kakugawa Y, et al.
    • Journal Title

      Familial cancer

      Volume: 15 Pages: 75-83

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimal use of colonoscopy and fecal immunochemical test for population-based colorectal cancer screening: a cost-effectiveness analysis using Japanese data.2016

    • Author(s)
      Sekiguchi M, Igarashi A, Matsuda T, Kakugawa Y, et al.
    • Journal Title

      Japanese journal of clinical oncology

      Volume: 46 Pages: 116-25

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endocuff((R))-assisted colonoscopy increases polyp detection rate: a simulated randomized study involving an anatomic colorectal model and 32 international endoscopists.2016

    • Author(s)
      Pioche M, Matsumoto M, Takamaru H, Kakugawa Y, et al.
    • Journal Title

      Surgical endoscopy

      Volume: 30 Pages: 288-95

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endocuff((R))-assisted colonoscopy increases polyp detection rate: a simulated randomized study involving an anatomic colorectal model and 32 international endoscopists2016

    • Author(s)
      Pioche M, Matsumoto M, Takamaru H, Kakugawa Y, et al
    • Journal Title

      Surgical endoscopy

      Volume: 30 Pages: 288-295

    • Related Report
      2015 Research-status Report
  • [Journal Article] Optimal use of colonoscopy and fecal immunochemical test for population-based colorectal cancer screening: a cost-effectiveness analysis using Japanese data2016

    • Author(s)
      Sekiguchi M, Igarashi A, Matsuda T, Kakugawa Y, et al
    • Journal Title

      Japanese journal of clinical oncology

      Volume: 46 Pages: 116-125

    • Related Report
      2015 Research-status Report
  • [Journal Article] Surveillance using capsule endoscopy is safe in post-colectomy patients with familial adenomatous polyposis: a prospective Japanese study2016

    • Author(s)
      Matsumoto M, Nakajima T, Kakugawa Y, et al
    • Journal Title

      Familial cancer

      Volume: 15 Pages: 75-83

    • Related Report
      2015 Research-status Report
  • [Journal Article] Impact of screening colonoscopy on outcomes in colorectal cancer2015

    • Author(s)
      Takahisa Matsuda, Akiko Ono, Yasuo Kakugawa, Minori Matsumoto, Yutaka Saito
    • Journal Title

      Japanese Journal of Clinical Oncology Advance Access published

      Volume: August7 Pages: 1-6

    • Related Report
      2015 Research-status Report
  • [Journal Article] Assessment of an electronic learning system for colon capsule endoscopy: a pilot stud2015

    • Author(s)
      Watabe H, Nakamura T, Yamada A, Kakugawa Y, Nouda S
    • Journal Title

      Journal of gastroenterology

      Volume: 0 Pages: 0-0

    • Related Report
      2015 Research-status Report
  • [Journal Article] Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study2015

    • Author(s)
      Shimazu T, Asada K, Charvat H, Kakugawa Y, et al
    • Journal Title

      Carcinogenesis

      Volume: 36 Pages: 1291-1298

    • Related Report
      2015 Research-status Report
  • [Journal Article] Evaluation of the clinical efficacy of colon capsule endoscopy in the detection of lesions of the colon: prospective, multicenter, open study2015

    • Author(s)
      Saito Y, Saito S, Oka S, Kakugawa Y, et al
    • Journal Title

      Gastrointestinal endoscopy

      Volume: 0 Pages: 0-0

    • Related Report
      2015 Research-status Report
  • [Journal Article] 大腸カプセル内視鏡:診断成績と実績の検査方法2015

    • Author(s)
      角川康夫、居軒和也、高丸博之、山田真善、松本美野里、松田尚久、斎藤豊
    • Journal Title

      消化器内視鏡

      Volume: Vol.27 Pages: 678-687

    • Related Report
      2015 Research-status Report
  • [Journal Article] 大腸カプセル内視鏡 前処置法の工夫2015

    • Author(s)
      角川康夫、居軒和也、高丸博之、山田真善、松本美野里、松田尚久、斎藤豊
    • Journal Title

      臨床消化器内科

      Volume: Vol.30 Pages: 1647-1654

    • Related Report
      2015 Research-status Report
  • [Journal Article] 【血便をみたら】 医原性出血 内視鏡治療の後出血2015

    • Author(s)
      松本 美野里, 高丸 博之, 山田 真善, 坂本 琢, 中島 健, 角川康夫, 松田 尚久, 斎藤 豊
    • Journal Title

      消化器内視鏡

      Volume: Vol.27 Pages: 1707-1712

    • Related Report
      2015 Research-status Report
  • [Journal Article] 大腸 有効性評価に基づく大腸がん検診ガイドライン2015

    • Author(s)
      松田 尚久, 角川康夫, 松本 美野里, 斎藤 豊
    • Journal Title

      消化器内視鏡

      Volume: Vol.27 Pages: 438-442

    • Related Report
      2015 Research-status Report
  • [Journal Article] 大腸カプセル内視鏡 適応と今後の展望2015

    • Author(s)
      斎藤 豊, 松本 美野里, 角川康夫
    • Journal Title

      Intestine

      Volume: 19 Pages: 79-80

    • Related Report
      2015 Research-status Report
  • [Journal Article] 超高齢者の大腸癌スクリーニング2015

    • Author(s)
      居軒 和也, 松田 尚久, 関口 正宇, 森 源喜, 高丸 博之, 山田 真善, 松本 美野里, 坂本 琢, 中島 健, 角川康夫, 斎藤 豊
    • Journal Title

      Intestine

      Volume: 19 Pages: 73-78

    • Related Report
      2015 Research-status Report
  • [Journal Article] Gene Expression Analysis Using a Highly Sensitive DNA Microarray for Colorectal Cancer Screening2014

    • Author(s)
      Yoshikatsu Koga, Nobuyoshi Yamazaki, Satoko Takizawa, Junpei Kawauchi, Osamu Nomura, Seiichiro Yamamoto, Norio Saito, Yasuo Kakugawa, Yosuke Otake, Minori Matsumoto, Yasuhiro Matsumura
    • Journal Title

      Anticancer Research January

      Volume: 34 Pages: 169-176

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] カプセル内視鏡の診断への応用2014

    • Author(s)
      角川康夫、松本美野里、斎藤豊
    • Journal Title

      日本臨牀

      Volume: 72 Pages: 168-174

    • Related Report
      2014 Research-status Report
  • [Journal Article] カプセル内視鏡の現状と展望2014

    • Author(s)
      角川康夫、松本美野里、斎藤豊
    • Journal Title

      日本消化器病学会雑誌

      Volume: 111 Pages: 464-469

    • Related Report
      2014 Research-status Report
  • [Journal Article] 大腸内視鏡による観察精度の評価とは(ADR)2014

    • Author(s)
      角川康夫、斎藤豊、松本美野里,大竹陽介、松田尚久
    • Journal Title

      消化器内視鏡

      Volume: 26 Pages: 898-899

    • Related Report
      2014 Research-status Report
  • [Journal Article] 大腸カプセル内視鏡検査の最前線2014

    • Author(s)
      角川康夫、松本美野里、斎藤豊
    • Journal Title

      大腸がんperspective

      Volume: 1 Pages: 48-51

    • Related Report
      2014 Research-status Report
  • [Presentation] 造血幹細胞移植後の小腸の観察に用いるカプセル内視鏡診断と移植関連死についての検討.2017

    • Author(s)
      居軒和也, 角川康夫, 斎藤豊,
    • Organizer
      日本造血幹細胞移植学会学術集会
    • Place of Presentation
      くにびきメッセ(島根県松江市学園南)
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] カプセル内視鏡の更なる発展を目指して 造血幹細胞移植後の小腸の観察に用いるカプセル内視鏡診断と移植関連死についての検討2016

    • Author(s)
      居軒和也, 角川康夫, 斎藤豊,
    • Organizer
      日本消化器内視鏡学会 総会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市港島中町)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 部消化管がんスクリーニング内視鏡 確実なスクリーニング法を目指して 当施設における胃がん・食道がん内視鏡検診の取り組み2016

    • Author(s)
      角川康夫, 松本美野里, 松田尚久, 斎藤豊
    • Organizer
      日本消化器内視鏡学会 関東支部会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区平河町)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 家族性大腸腺腫症の十二指腸病変に対するバイポーラスネアを用いた内視鏡治療の短期成績.2016

    • Author(s)
      居軒和也, 中島健, 野中哲, 高丸博之, 関口正宇, 山田真善, 阿部清一郎, 坂本琢, 鈴木晴久, 吉永繁高, 角川康夫, 松田尚久, 小田一郎, 斎藤豊.
    • Organizer
      日本消化器内視鏡学会 関東支部会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区平河町)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Per Polyp Sensitivity of Colon Capsule Endoscopy According to Pathological Diagnosis2015

    • Author(s)
      Yasuo Kakugawa, Shiro Oka, Shoichi Saito, Sadaharu Nouda, Kenji Watanabe, Naoki Ohmiya, Hiroyuki Aihara, Minori Matsumoto, Ikue Watari, Taiki Aoyama, Takanori Kuramoto, Kazuhide Higuchi, Hidemi Goto , Tetsuo Arakawa, Shinji Tanaka, Yutaka Saito, Hisao Tajiri
    • Organizer
      UEGW
    • Place of Presentation
      Spain
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 本邦における大腸カプセル内視鏡のこれまでの取り組みと今後の諸課題2015

    • Author(s)
      角川康夫、松本美野里、斎藤豊
    • Organizer
      第8回日本カプセル内視鏡学会学術集会
    • Place of Presentation
      東京都新宿
    • Year and Date
      2015-02-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 当施設における胃がん検診の取り組み2015

    • Author(s)
      角川康夫、松本美野里、大竹陽介、村松幸男、斎藤豊
    • Organizer
      第11回日本消化管学会総会学術集会
    • Place of Presentation
      東京都新宿
    • Year and Date
      2015-02-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 便潜血検査補助診断としての便中miR-106aの有効性2014

    • Author(s)
      山崎信義、古賀宣勝、松本美野里、大竹陽介、角川康夫
    • Organizer
      第22回日本消化器関連学会週間: JDDW
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸カプセル内視鏡による病変描出能の検討2014

    • Author(s)
      高丸博之、角川康夫、斎藤豊
    • Organizer
      第22回日本消化器関連学会週間: JDDW
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸切除後の家族性大腸腺腫症患者に対するカプセル内視鏡の安全性の検討2014

    • Author(s)
      松本美野里、中島健、角川康夫、坂本琢、大竹陽介、松田尚久、斎藤豊
    • Organizer
      日本消化器内視鏡学会関東地方会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 経鼻内視鏡の進歩と実際細径内視鏡と通常径内視鏡における胃癌検出についての比較検討 特に小さな陥凹型粘膜内癌に注目して2014

    • Author(s)
      森源喜、大竹陽介、松本美野里、角川康夫、村松幸男、斎藤豊
    • Organizer
      日本消化器内視鏡学会関東地方会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Research-status Report
  • [Book] 内視鏡医のための大腸ポリープ マネジメント2015

    • Author(s)
      角川康夫、松本美野里、斎藤豊
    • Total Pages
      242
    • Publisher
      日本メディカルセンター
    • Related Report
      2015 Research-status Report
  • [Book] 大腸腺腫・大腸がん2015

    • Author(s)
      角川康夫、松本美野里、山田真善、関口正宇、坂本 琢、中島健、松田尚久、斎藤 豊
    • Total Pages
      270
    • Publisher
      最新医学社
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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