Diffusion Kurtosis Imaging of the Pancreas for the Assessement of HbA1c Levels

• Project/Area Number: 26461820
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gifu University
• Principal Investigator: Noda Yoshifumi 岐阜大学, 医学部附属病院, 助教 (60643020)
• Co-Investigator(Kenkyū-buntansha): 兼松 雅之 岐阜大学, 医学部附属病院, 准教授 (40252134) ; 五島 聡 岐阜大学, 医学部附属病院, 准教授 (90402205) ; 近藤 浩史 帝京大学, 医学部, 教授 (20324311) ; 渡邊 春夫 岐阜大学, 大学院医学系研究科, 非常勤講師 (30456529) ; 棚橋 裕吉 岐阜大学, 医学部附属病院, 医員 (40724563) ; 河合 信行 岐阜大学, 医学部附属病院, 助教 (20724561)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 拡散尖度画像 / 糖尿病

Outline of Final Research Achievements

One-hundred-two patients underwent MR imaging included dufusion kurtosis imaging. Patients were classified into three groups using HbA1c values, HbA1c < 5.7% (group 1); 5.7% < HbA1c < 6.5% (group 2); and HbA1c > 6.5% (group 3). Radiologist measured the ADC and K values of the pancreas and compared among 3 groups.
Group 3 was significantly higher in K value than groups 1 and 2. The diagnostic performance for differentiating group 3 from groups 1 and 2 was superior compared with ADC value. These results suggest that the K value of the pancreas may be a better biomarker for grading pancreatic fibrosis and glucose intolerance than the ADC value.

Research Products

• [Journal Article] Diffusion kurtosis imaging of the pancreas for the assessment of HbA1c levels. (2016)
  • Author(s): Y. Noda, M. Kanematsu, S. Goshima, Y. Horikawa, J. Takeda, H. Kondo, H. Watanabe, H. Kawada, N. Kawai, Y. Takahashi, and K. T. Bae.
  • Journal Title: J. Magn. Reson. Imaging. Volume: 43 Issue: 1 Pages: 159-165
  • DOI: 10.1002/jmri.24982
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 膵臓のMRI診断Update：拡散強調画像を中心に (2015)
  • Author(s): 野田 佳史
  • Organizer: 第43回日本磁気共鳴学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-12
  • Invited
• [Presentation] 拡散尖度画像を用いた糖尿病重症度に関する検討 (2014)
  • Author(s): 河合 信行
  • Organizer: 第42回日本磁気共鳴学会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18
• [Presentation] Diffusion kurtosis imagingを用いた糖尿病重症度に関する検討 (2014)
  • Author(s): 野田 佳史
  • Organizer: 日本放射線学会 第156回中部地方会
  • Place of Presentation: 福井
  • Year and Date: 2014-07-06