| Project/Area Number |
26461822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石田 正樹 三重大学, 医学部附属病院, 助教 (10456741)
北川 覚也 三重大学, 医学部附属病院, 講師 (50378353)
佐久間 肇 三重大学, 医学系研究科, 教授 (60205797)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 冠血流計測 / MRI / 位相コントラストシネMRI / PET / 心筋血流予備能 / 冠動脈 / 冠血流予備能 / 15O-H2O心筋血流PET / Coronary flow reserve / Fractional flow reserve |
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| Outline of Final Research Achievements |
<Purpose> To evaluate the value of coronary flow velocity reserve (CFVR) measured by phase-contrast cine MRI (PC-MRI) for detecting impaired myocardial perfusion reserve (MPR) in patients, using 15O-labeled water positron emission tomography (PET) as a reference. <Methods> PC-MRI and PET flow measurements were performed in 13 patients. CFVR in RCA was measured with 3T PC-MRI in 13 patients and was compared with thje MPR in the RCA territory determined by PET. <Results> CFVR in RCA was successfully determined with PC-MRI in all subjects. The CFVR in patients with impaired MPR (<2.0) was significantly lower than that with preserved MPR (>2.0) (1.3±0.3 vs 2.2±1.2, p=0.03). Using a CFVR threshold of 1.5, the sensitivity and specificity for detecting impaired MPR was 80% (4/5) and 100% (8/8), respectively. <Conclusion> CFVR determined by PC-MRI can provide noninvasive detection of impaired myocardial perfusion reserve, without radiation exposure and contrast media.
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