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Visualization of organic brain disease by fusion of white matter fiber tracking and intercortical functional connectome analysis

Research Project

Project/Area Number 26461824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

TSUTOMU OKADA  京都大学, 医学研究科, 特定病院助教 (40726824)

Co-Investigator(Kenkyū-buntansha) 岡田 知久  京都大学, 医学研究科, 特定准教授 (30321607)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords拡散強調MRI / NODDI / tractography / 運動ニューロン病 / 大脳皮質機能分布 / 拡散強調画像 / MRI / 拡散テンソル画像 / マルチバンドEPI / マルチバンドMRI / 皮質間結合 / tract specific analysis / 神経変性疾患
Outline of Final Research Achievements

High-speed MR imaging acquisition method using multiband RF excitation was established. As a result, a new diffusion MR analysis method (NODDI) have been available. Different from diffusion tensor imaging which describe white matter anisotropy as an simple ellipsoid model, NODDI can delineate the microstructure of the cerebral cortex as well as white matter by calculating two independent indices; neurite density and axonal orientation dispersion. From the NODDI data, high angular resolution diffusion imaging was simultaneously obtained, which was able to be applied to q-ball imaging based fiber tractogarphy.
Our two ongoing studies are as follows; creation of cerebral cortical functional segmentation according to cortical microstructure using NODDI, and to establish corticospinal tract tractography that is capable of estimating the motor function disability in motor neuron disease patients using q-ball imaging.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] T1-weighted MR imaging of glioma at 3T: a comparative study of 3D MPRAGE vs. conventional 2D spin-echo imaging2016

    • Author(s)
      Dodo T, Okada T, Yamamoto A, Kanagaki M, Fushimi Y, Okada T, Sakata A, Arakawa Y, Miyamoto S, Togashi K
    • Journal Title

      Clin Imaging

      Volume: 40 Issue: 6 Pages: 1257-1261

    • DOI

      10.1016/j.clinimag.2016.08.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic resonance imaging of pituitary gland and postsphenoid ossification in fetal specimens2016

    • Author(s)
      Mehemed TM, Fushimi Y, Okada T,Kanagaki M,Okada T, Yamamoto A, TakakuwaT,Yamada S, Togashi K
    • Journal Title

      Am J Neuroradiology

      Volume: 37 Issue: 8 Pages: 1523-7

    • DOI

      10.3174/ajnr.a4808

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MP2RAGE for deep gray matter measurement of the brain: A comparative study with MPRAGE.2016

    • Author(s)
      Gosuke Okubo, Tomohisa Okada, Akira Yamamoto, Mitsunori Kanagaki, Yasutaka Fushimi, Tsutomu Okada, Katsuhisa Murata, and Kaori Togashi
    • Journal Title

      J Magn Reson Imaging

      Volume: 43(1) Issue: 1 Pages: 55-62

    • DOI

      10.1002/jmri.24960

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative Susceptibility Mapping at 3 T and 1.5 T: Evaluation of Consistency and Reproducibility.2015

    • Author(s)
      Takuya Hinoda, Yasutaka Fushimi, Tomohisa Okada, Koji Fujimoto, C. Liu, Akira Yamamoto, Tsutomu Okada, Aki Kido, and Kaori Togashi.
    • Journal Title

      Invest Radiol

      Volume: 50(8) Issue: 8 Pages: 522-30

    • DOI

      10.1097/rli.0000000000000159

    • NAID

      120005601016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diffusion tensor imaging analysis of optic radiation using readout-segmented echo-planar imaging.2014

    • Author(s)
      Yamada H, Yamamoto A, Okada T, Kanagaki M, Fushimi Y, Mehemed TM, Porter DA, Togashi K.
    • Journal Title

      Surg Radiol Anat.

      Volume: 36(10) Issue: 10 Pages: 973-980

    • DOI

      10.1007/s00276-014-1299-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of Susceptibility-Weighted Images of Cortico-Medullary Junction.2014

    • Author(s)
      Mehemed TM, Yamamoto A, Okada T, Kanagaki M, Sawada T, Morimoto E, Takahashi JC, Miyamoto S, Togashi K.
    • Journal Title

      Magn Reson Med Sci.

      Volume: 13 Pages: 231-8

    • NAID

      130004685117

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 3D dynamic pituitary MR imaging with CAIPIRINHA: initial experience and comparison with 2D dynamic MR imaging.2014

    • Author(s)
      Fushimi Y, Okada T, Kanagaki M, Yamamoto A, Kanda Y, Sakamoto R, Hojo M, Takahashi JC, Miyamoto S, Togashi K.
    • Journal Title

      Eur J Radiol.

      Volume: 83 Pages: 1900-6

    • NAID

      120005606118

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Visualiza3on of Auditory Ossicles and Facial Nerve Canal: Comparison between Ultrashort TE MR and CT.2016

    • Author(s)
      Takao Kumazawa, Yasutaka Fushimi, Tomohisa Okada, Takuya Hinoda, Tsutomu Okada, Akira Yamamoto, Yutaka Natsuaki, and Kaori Togashi
    • Organizer
      ISMRM 24th Annual Meeting & Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The pointwise encoding time reduction with radial acquisition (PETRA) sequence: visualization of intracranial arteries and facial nerve canals2016

    • Author(s)
      Sachi Okuchi, Yasutaka Fushimi, Tomohisa Okada, Akira Yamamoto, Tsutomu Okada, Takuya Hinoda, Yutaka Natsuaki, and Kaori Togashi
    • Organizer
      ISMRM 24th Annual Meeting & Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent advancement in fast, low‐distortion and high‐resolution diffusion imaging with clinical implications in optic pathways analysis2015

    • Author(s)
      Tsutomu Okada
    • Organizer
      Neuroimaging Summit 2015
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 3テスラMRIにおける定量的磁化率マッピングの初期経験2014

    • Author(s)
      日野田卓也、伏見育崇、岡田知久、山本憲、金柿光憲、岡田務、坂本亮、Taha Mehemed、中島諭、山田浩史、 奥知左智、柿木崇秀、坂田昭彦、百々俊樹、大久保豪祐、山内盛敬、山本貴之、藤本晃司、木戸晶、坂下尚孝、富樫かおり
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Radiation-Associated Neoplasm: What Radiologists Should Know2014

    • Author(s)
      Sakata A, T Okada, Yamamoto A, Kanagaki M, Fushimi Y, Dodo T, Togashi K.
    • Organizer
      American Society of Neuroradiology
    • Place of Presentation
      カナダ、ケベック州モントリオール市
    • Year and Date
      2014-05-17 – 2014-05-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 3D dynamic pituitary MR imaging with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)2014

    • Author(s)
      Yasutaka Fushimi, Tomohisa Okada, Mitsunori Kanagaki, Akira Yamamoto, Yumiko Kanda, Ryo Sakamoto, Masato Hojo, Jun C. Takahashi, Susumu Miyamoto, Kaori Togashi.
    • Organizer
      International Society of Magnetic Resonance in Medicine
    • Place of Presentation
      イタリア共和国、ミラノ市
    • Year and Date
      2014-05-10 – 2014-05-16
    • Related Report
      2014 Research-status Report
  • [Book] RadFan Vol.14 No.4 『2016 MRI最新動向」2016

    • Author(s)
      岡田 務
    • Total Pages
      3
    • Publisher
      メディカルアイ
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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