| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We developed in vivo magnetic resonance microscopy by combining hypothermic anesthesia and a 14.1 T MR microscope. Using a in vivo MR microscopy, we noninvasively evaluated the hepatic steatosis level of a non-alcoholic fatty liver disease model in medaka as the triglyceride fat concentration in liver tissue and followed the individual disease progression. Moreover, we optimized the hypothermic anesthesia procedure to obtain a recovery proportion of 1 in the experiment involving MR microscopy. The in vivo MR microscopy will expand the possibilities of a human disease model in fish.
In addition, we improved spatial resolution and quantitative accuracy of MRI quantitative susceptibility mapping using wider band dipole inversion. This leads to more quantitative evaluation of iron deposits and oxygen consumption in a brain tissue.
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