In vivo Imaging of a Disease Model in Medaka by 14.1 T MR Microscopy
| Project/Area Number |
26461825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
Ueno Tomohiro 京都大学, 医学研究科, 助教 (10379034)
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| Co-Investigator(Kenkyū-buntansha) |
杉本 直三 京都大学, 医学研究科, 教授 (20196752)
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| Research Collaborator |
SUZUKI Hirokazu
UMEMOTO Yuya
HARAGUCHI Sakura
MUTO Sayano
KOKAJI Haruka
NISHIGAKI Takahiro
MUNAKATA Taro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 磁気共鳴映像法 / 非アルコール性脂肪性肝疾患 / 定量的磁化率マッピング / 核磁気共鳴映像法 / 非アルコール性脂肪肝 |
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| Outline of Final Research Achievements |
We developed in vivo magnetic resonance microscopy by combining hypothermic anesthesia and a 14.1 T MR microscope. Using a in vivo MR microscopy, we noninvasively evaluated the hepatic steatosis level of a non-alcoholic fatty liver disease model in medaka as the triglyceride fat concentration in liver tissue and followed the individual disease progression. Moreover, we optimized the hypothermic anesthesia procedure to obtain a recovery proportion of 1 in the experiment involving MR microscopy. The in vivo MR microscopy will expand the possibilities of a human disease model in fish.
In addition, we improved spatial resolution and quantitative accuracy of MRI quantitative susceptibility mapping using wider band dipole inversion. This leads to more quantitative evaluation of iron deposits and oxygen consumption in a brain tissue.
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Report
(4 results)
Research Products
(17 results)
