A comprehensive approach to diagnosis of brain tumors by quantifying diffusivity and microcapillary perfusion components using high field MRI

• Project/Area Number: 26461828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Yamashita Koji 九州大学, 大学病院, 助教 (80546565)
• Co-Investigator(Kenkyū-buntansha): 樋渡 昭雄 九州大学, 大学病院, 助教 (30444855) ; 栂尾 理 九州大学, 大学病院, 助教 (10452749) ; 吉浦 敬 鹿児島大学, 医歯学域医学系, 教授 (40322747) ; 本田 浩 九州大学, 医学研究院, 教授 (90145433)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: IVIM / 拡散強調像 / 脳腫瘍 / 灌流強調画像 / 拡散強調画像 / MRI

Outline of Final Research Achievements

IVIM MR imaging allows the simultaneous extraction of perfusion and diffusion parameters. In our study, IVIM MR imaging non-invasively provides useful quantitative information in distinguishing between PCNSL and GBM. We also reported that IVIM MR imaging is useful for differentiating between high- and low-grade gliomas.

Research Products

• [Journal Article] Diagnostic Utility of Intravoxel Incoherent Motion MR imaging in Differentiating Primary Central Nervous System Lymphoma from Glioblastoma Multiforme (2016)
  • Author(s): .Yamashita K, Hiwatashi A, Togao O, et al.
  • Journal Title: J Magn Reson Imaging. Volume: 44(5) Issue: 5 Pages: 1256-1261
  • DOI: 10.1002/jmri.25261
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differentiation of high-grade and low-grade diffuse gliomas by intravoxel incoherent motion MR imaging. (2016)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Mizoguchi M, Yoshimoto K, Suzuki SO, Iwaki T, Obara M, Van Cauteren M, Honda H.
  • Journal Title: Neuro Oncol. Volume: 18 Issue: 1 Pages: 132-141
  • DOI: 10.1093/neuonc/nov147
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MR imaging Based Analysis of Glioblastoma multiforme: Estimation of IDH1 Mutation Status. (2016)
  • Author(s): Yamashita K, Hiwatashi A, Togao O et al.
  • Journal Title: Am J Neuroradiol. Volume: 37(1) Issue: 1 Pages: 58-65
  • DOI: 10.3174/ajnr.a4491
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MR imaging findings of a leiomyosarcoma of the thoracic spine: A case report. (2015)
  • Author(s): Tahara K, Yamashita K, Hiwatashi A, et al.
  • Journal Title: Clin Neuroradiol. Volume: Epub ahead of print Issue: 2 Pages: 1-5
  • DOI: 10.1007/s00062-015-0420-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: (2014)
  • Author(s): Uehara R, Yamashita K, Hiwatashi A, Togao O, Kikuchi K, Yokoyama J, Matsuse D, Yoshiura T, Honda
  • Journal Title: Brain and behavior Volume: 4 Issue: 6 Pages: 798-800
  • DOI: 10.1002/brb3.282
  • Peer Reviewed / Open Access
• [Presentation] Diagnostic Utility of Intravoxel Incoherent Motion MR imaging in Differentiating Primary Central Nervous System Lymphoma from Glioblastoma Multiforme (2016)
  • Author(s): 山下 孝二
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-04-14
  • Int'l Joint Research
• [Presentation] Perfusion fraction measurements with intravoxel incoherent motion MR imaging: comparison with histopathologic vascular density and dynamic susceptibility contrast perfusion imaging in meningiomas (2015)
  • Author(s): Osamu Togao, Akio Hiwatashi, Koji Yamashita et al.
  • Organizer: 101st Scientific Assembly and annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Diagnostic utility of the combination of intravoxel incoherent motion MR imaging and 18FDG-PET in differentiating primary CNS lymphoma from glioblastoma multiforme (2015)
  • Author(s): Koji Yamashita et al.
  • Organizer: 10th Asian Oceanian Congress of neuroradiology
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] 胸椎原発平滑筋肉腫の一例 (2015)
  • Author(s): 田原圭一郎、山下 孝二、樋渡 昭雄、栂尾 理、菊地 一史、遠藤 誠、小田 義直、本田 浩
  • Organizer: 第180回日本医学放射線学会九州地方会
  • Place of Presentation: 福岡市
  • Year and Date: 2015-02-14 – 2015-02-15
• [Remarks] 九州大学大学院臨床放射線科学分野ホームページ
  • URL: http://www.radiol.med.kyushu-u.ac.jp/
• [Remarks] 九州大学大学院医学研究院臨床放射線科学分野ホームページ
  • URL: http://www.radiol.med.kyushu-u.ac.jp/
• [Funded Workshop] The 102nd Scientific Assembly & Annual Meeting of the Radiological Society of North America (2016)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-27
• [Funded Workshop] ASNR 54th Annual Meeting (2016)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2016-05-21