| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Purpose: To evaluate the pharmacokinetics of intraarterial (IA) administration of micellar nanoparticles incorporating SN-38 (NK012) injection compared with intravenous (IV) administration in a rabbit liver tumor model. Methods: 18 rabbits with VX2 liver tumors were divided into two groups. NK012 and free SN-38 in the plasma, liver parenchyma, and tumors were measured within 24 hours. Results: There were no significant differences in the serum area under the concentration-time curve for free SN-38, at 1,500 and 1,310 μg*min/mL in the IA and IV groups, respectively. The IA group showed significantly higher free SN-38 concentrations in tumor tissues at all time points compared with the IV group. Histologic findings showed that significantly higher tumor necrosis ratios were observed in the IA group compared with the IV group at 24 hours. Conclusions: Micellar nanoparticles could be a promising IA drug delivery system to achieve high tumor tissue concentrations of SN-38.
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