Pharmacokinetics and pharmacodynamics evaluation of micellar nanoparticles incorporating SN-38 using molecular imaging
| Project/Area Number |
26461833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUSHIMA Shgeru 愛知県がんセンター, 遺伝子医療研究部, 研究員 (70444297)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ナノDDS / 肝転移モデル / 動注療法 / ミセル化粒子 / ミセル化ナノ粒子 |
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| Outline of Final Research Achievements |
Purpose: To evaluate the pharmacokinetics of intraarterial (IA) administration of micellar nanoparticles incorporating SN-38 (NK012) injection compared with intravenous (IV) administration in a rabbit liver tumor model. Methods: 18 rabbits with VX2 liver tumors were divided into two groups. NK012 and free SN-38 in the plasma, liver parenchyma, and tumors were measured within 24 hours. Results: There were no significant differences in the serum area under the concentration-time curve for free SN-38, at 1,500 and 1,310 μg*min/mL in the IA and IV groups, respectively. The IA group showed significantly higher free SN-38 concentrations in tumor tissues at all time points compared with the IV group. Histologic findings showed that significantly higher tumor necrosis ratios were observed in the IA group compared with the IV group at 24 hours. Conclusions: Micellar nanoparticles could be a promising IA drug delivery system to achieve high tumor tissue concentrations of SN-38.
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Report
(5 results)
Research Products
(8 results)
