Non Gaussian diffusion images for Alzheimer's disease

• Project/Area Number: 26461834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya University (2015-2016); Nara Medical University (2014)
• Principal Investigator: Toshiaki Taoka 名古屋大学, 医学部附属病院, 病院准教授 (30305734)
• Co-Investigator(Kenkyū-buntansha): 吉川 公彦 奈良県立医科大学, 医学部, 教授 (10161506) ; 安野 史彦 奈良県立医科大学, 医学部, 准教授 (60373388) ; 岸本 年史 奈良県立医科大学, 医学部, 教授 (60201456) ; 和田 敬 奈良県立医科大学, 医学部, 助教 (90597098)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アルツハイマー病 / 拡散MRI / 認知症 / ＭＲＩ / 拡散画像 / 拡散尖度画像

Outline of Final Research Achievements

We analyzed cases of Alzheimer’s disease cases using Non-Gaussian diffusion images. The cases were also clinically evaluated including MMSE score and divided into Alzheimer’s disease group, mild cognitive impairment group and subjective cognitive impairment group. By using 3T MR imager, we acquired Non-Gaussian diffusion images and generated diffusion kurtosis images (DKI). DKI showed the decreased diffusion kurtosis in the uncinated fascicles in correlation with severity of the Alzheimer’s disease. That may indicate abnormality in the microstructure of the white matter in the uncinated fascicles which is a part of limbic system.

Research Products

• [Journal Article] Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. (2017)
  • Author(s): Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S.
  • Journal Title: Jpn J Radiol Volume: 35 Issue: 4 Pages: 172-178
  • DOI: 10.1007/s11604-017-0617-z
  • NAID: 120006323685
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion tensor tractography in the preoperative precise identification of the course of facial nerve in a meningioma of the cerebellopontine angle; Technical implications (2017)
  • Author(s): Goncalo Neto d'Almeida, Luis Sousa Marques, Pedro Escada, Toshiaki Taoka, Pedro Goncalves Pereira
  • Journal Title: Interdisciplinary Neurosurgery Volume: 9 Pages: 58-60
  • DOI: 10.1016/j.inat.2017.03.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Revisiting current golden rules in managing acute ischemic stroke: evaluation of new strategies to further improve treatment selection and outcome (2017)
  • Author(s): William TC Yuh, Matthew David Alexander, Toshihiro Ueda, Masayuki Maeda, Toshiaki Taoka, Kei Yamada, Norman J Beauchamp
  • Journal Title: American Journal of Roentgenology Volume: 208 Issue: 1 Pages: 32-41
  • DOI: 10.2214/ajr.16.16557
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders. (2017)
  • Author(s): Toshiaki Taoka, Akio Fukuisumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa
  • Journal Title: Radiographics. Volume: 37(1) Issue: 1 Pages: 281-297
  • DOI: 10.1148/rg.2017160061
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of non-suture dural closure using a novel dural substitute consisting of polyglycolic acid felt and fibrin glue to prevent cerebrospinal fluid leakage-A non-controlled, open-label, multicenter clinical trial. (2017)
  • Author(s): Terasaka S, Taoka T, Kuroda S, Mikuni N, Nishi T, Nakase H, Fujii Y, Hayashi Y, Murata JI, Kikuta KI, Kuroiwa T, Shimokawa S, Houkin K.
  • Journal Title: J Mater Sci Mater Med Volume: 28 Issue: 5 Pages: 69-69
  • DOI: 10.1007/s10856-017-5877-8
  • NAID: 120006459307
  • Peer Reviewed
• [Journal Article] Structures Showing Negative Correlations of Signal Intensity with Postnatal Age on T₁-weighted Imaging of the Brain of Newborns and Infants (2017)
  • Author(s): Saeka Hori, Toshiaki Taoka, Tomoko Ochi, Toshiteru Miyasaka, Masahiko Sakamoto, Katsutoshi Takayama, Takeshi Wada, Kaoru Myochin, Yukihiro Takahashi, Kimihiko Kichikawa
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 4 Pages: 325-331
  • DOI: 10.2463/mrms.mp.2015-0168
  • NAID: 130006163826
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging (2017)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, David Grodzki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 2 Pages: 93-97
  • DOI: 10.2463/mrms.mp.2015-0171
  • NAID: 130005589296
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia (2017)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 1 Pages: 61-65
  • DOI: 10.2463/mrms.mp.2016-0039
  • NAID: 130005286866
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System (2017)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 2 Pages: 89-90
  • DOI: 10.2463/mrms.ci.2016-0114
  • NAID: 130005589284
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer’s disease and mild cognitive impairment: Do white matter changes precede gray matter changes? (2016)
  • Author(s): Toshiaki Taoka,corresponding author Fumihiko Yasuno, Masayuki Morikawa, Makoto Inoue, Kuniaki Kiuchi, Soichiro Kitamura, Kiwamu Matsuoka, Toshifumi Kishimoto, Kimihiko Kichikawa, Shinji Naganawa
  • Journal Title: SpringerPlus. Volume: 5(1) Issue: 1 Pages: 1023-1023
  • DOI: 10.1186/s40064-016-2692-5
  • Peer Reviewed / Open Access
• [Journal Article] Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume. (2016)
  • Author(s): Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Saeka Hori, Tomoko Ochi, Toshiteru Miyasaka, Masahiko Sakamoto, Kimihiko Kichikawa, Shinji Naganawa
  • Journal Title: Magn Reson Imaging. Volume: 34(7) Issue: 7 Pages: 896-901
  • DOI: 10.1016/j.mri.2016.04.020
  • Peer Reviewed / Open Access
• [Journal Article] Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model. (2016)
  • Author(s): Taoka T, Fujioka M, Kashiwagi Y, Obata A, Rokugawa T, Hori M, Masutani Y, Aoki S, Naganawa S, Abe K.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 25 Issue: 3 Pages: 610-617
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dural Thickening of the Internal Auditory Canal in Patients With Spontaneous Intracranial Hypotension Syndrome. (2016)
  • Author(s): Hori S, Taoka T, Miyasaka T, Ochi T, Sakamoto M, Wada T, Myochin K, Takayama K, Kichikawa K.
  • Journal Title: J Comput Assist Tomogr. Volume: 40 Issue: 2 Pages: 297-300
  • DOI: 10.1097/rct.0000000000000342
  • Peer Reviewed
• [Journal Article] Heavily T₂-Weighted 3D-FLAIR Improves the Detection of Cochlear Lymph Fluid Signal Abnormalities in Patients with Sudden Sensorineural Hearing Loss (2016)
  • Author(s): Naganawa S, Kawai H, Taoka T, Suzuki K, Iwano S, Satake H, Sone M, Ikeda M.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 15 Issue: 2 Pages: 203-211
  • DOI: 10.2463/mrms.mp.2015-0065
  • NAID: 130005144172
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Utility of High-b-Value Diffusion-Weighted Magnetic Resonance Imaging in Evaluating Reversible Medial Longitudinal Fasciculus Syndrome Caused by Acute Brainstem Ischemia. (2015)
  • Author(s): Miki Y, Fujioka M, Taoka T, Tanaka H, Chitoku S, Matsuyama T, Tanaka S.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 24 Issue: 6 Pages: 157-159
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1. (2015)
  • Author(s): Sugie K, Sugie M, Taoka T, Tonomura Y, Kumazawa A, Izumi T, Kichikawa K, Ueno S.
  • Journal Title: PLoS One. Volume: 10 Issue: 4 Pages: e0125051-e0125051
  • DOI: 10.1371/journal.pone.0125051
  • Peer Reviewed / Open Access
• [Journal Article] A case of meningococcal meningitis with multiple cerebellar microbleeds detected by susceptibility-weighted imaging. (2015)
  • Author(s): Miyazaki K, Fukushima H, Kogeichi Y, Watanabe T, Norimoto K, Taoka T, Okuchi K.
  • Journal Title: BMC Med Imaging. Volume: 15 Issue: 1 Pages: 45-45
  • DOI: 10.1186/s12880-015-0090-z
  • Peer Reviewed / Open Access
• [Journal Article] "Cerebellar peduncle quarter notes" formed by the superior and middle cerebellar peduncles: comparison with a diffusion tensor study of spinocerebellar degeneration. (2015)
  • Author(s): Ochi T, Taoka T, Miyasaka T, Wada T, Sakamoto M, Hori S, Kichikawa K.
  • Journal Title: Jpn J Radiol. Volume: 33 Issue: 4 Pages: 210-215
  • DOI: 10.1007/s11604-015-0409-2
  • NAID: 50009435109
  • Peer Reviewed
• [Journal Article] A Magnetic Resonance Imaging Technique to Evaluate Tumor-Brain Adhesion in Meningioma: Brain-Surface Motion Imaging (2015)
  • Author(s): Yamada S, Taoka T, Nakagawa I, Nishimura F, Motoyama Y, Park YS, Nakase H, Kichikawa K
  • Journal Title: World Neurosurg Volume: 83 Issue: 1 Pages: 102-107
  • DOI: 10.1016/j.wneu.2013.02.015
  • Peer Reviewed / Open Access
• [Journal Article] Time course and period of pseudo-normalization of diffusion kurtosis after cerebral infarctions: Analysis for perforator, white matter territorial, cortical and watershed infarctions (2014)
  • Author(s): Taoka T, Fujioka M, Sakamoto M, Miyasaka T, Akashi T, Ochi T, Hori S, Uchikoshi M, Xu J, Kichikawa K
  • Journal Title: AJNR Am J Neuroradiol Volume: 35 Issue: 8 Pages: 1509-1514
  • DOI: 10.3174/ajnr.a3908
  • Peer Reviewed
• [Journal Article] Decision-making deficit of a patient with axonal damage after traumatic brain injury. (2014)
  • Author(s): Yasuno F, Matsuoka K, Kitamura S, et al.
  • Journal Title: Brain and Cognition Volume: 84 Issue: 1 Pages: 63-82
  • DOI: 10.1016/j.bandc.2013.11.005
  • Peer Reviewed
• [Journal Article] Gray and White Matter Changes in Subjective Cognitive Impairment, Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Voxel-Based Analysis Study. (2014)
  • Author(s): Kiuchi K, Kitamura S, Taoka T, Yasuno F, Tanimura M, Matsuoka K, Ikawa D, Toritsuka M, Hashimoto K, Makinodan M, Kosaka J, Morikawa M, Kichikawa K, Kishimoto T
  • Journal Title: PLoS One Volume: 9 Issue: 8 Pages: e104007-e104007
  • DOI: 10.1371/journal.pone.0104007
  • Peer Reviewed / Open Access
• [Journal Article] Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors (2014)
  • Author(s): Ochi T, Taoka T, Matsuda R, Sakamoto M, Akashi T, Tamamoto T, Sugimoto T, Sakaguchi H, Hasegawa M, Nakase H, Kichikawa K
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 13 Issue: 4 Pages: 221-229
  • DOI: 10.2463/mrms.2013-0068
  • NAID: 130004685116
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Presentation] Evaluating glymphatic system by diffusion images: Alzheimer's disease cases analyzed by Diffusion Tensor Image analysis Along Perivascular Space (DTI-ALPS) (2017)
  • Author(s): Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Shinji Naganawa
  • Organizer: International Society for Magnetic Resonance in Medicine 2017
  • Place of Presentation: 米国、ホノルル
  • Year and Date: 2017-04-26
  • Int'l Joint Research
• [Presentation] Intracellular volume fraction image on NODDI in diffuse axonal injury. (2016)
  • Author(s): Toshiaki Taoka, Hisashi Kawai,Toshiki Nakane, Shinji Naganawa
  • Organizer: 102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)
  • Place of Presentation: 米国、シカゴ
  • Year and Date: 2016-11-29
  • Int'l Joint Research
• [Presentation] White matter lesions and blood-brain barrier(BBB) dysfunction: role of gadolinium-based contrast agents(GBCAs) (2016)
  • Author(s): Toshiaki Taoka
  • Organizer: The Frontiers Neuroimaging 2016
  • Place of Presentation: 韓国、ソウル
  • Year and Date: 2016-10-22
  • Int'l Joint Research / Invited
• [Presentation] DTI in Alzheimer's dementia research. (2016)
  • Author(s): Toshiaki Taoka
  • Organizer: MEDICAL Neuroimaging Summit 2016
  • Place of Presentation: 台湾、台北
  • Year and Date: 2016-09-24
  • Int'l Joint Research / Invited
• [Presentation] 拡散で脳微細構造をみる (2016)
  • Author(s): 田岡俊昭
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県神戸市中央区)
  • Year and Date: 2016-05-18
  • Invited
• [Presentation] Management of brain tumor by advanced neuroimaging. (2016)
  • Author(s): Toshiaki Taoka
  • Organizer: APAC Star Tianjin
  • Place of Presentation: 中国、天津
  • Year and Date: 2016-05-14
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of vascular permeability in gliomas by using parameter K2 from dynamic susceptibility contrast data-sets and histogram analysis (2016)
  • Author(s): Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Toshiteru Miyasaka, Shinji Naganawa
  • Organizer: International Society for Magnetic Resonance in Medicine 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-09
  • Int'l Joint Research
• [Presentation] 頭部外傷のadvanced MRI (2016)
  • Author(s): 田岡俊昭
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市西区）
  • Year and Date: 2016-04-15
  • Invited
• [Presentation] Update in advanced neuroimaging (2016)
  • Author(s): Toshiaki Taoka
  • Organizer: 4th International COngress on Magnetic Resonance Imaging
  • Place of Presentation: Seoul、韓国
  • Year and Date: 2016-03-25
  • Int'l Joint Research / Invited
• [Presentation] Structural and functional analysis of the brain using diffusion images. (2015)
  • Author(s): Toshiaki Taoka
  • Organizer: Asian-Oceanian Society of Neuroradiology and Head & Neck Radiology
  • Place of Presentation: ヒルトン福岡（福岡市中央区）
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] The role of MRI in brain tumor management (2015)
  • Author(s): Taoka T
  • Organizer: 4th Biennial Congress of the Asian Leksell Gamma Knife Society
  • Place of Presentation: Yokohama
  • Year and Date: 2015-02-21 – 2015-02-22
  • Invited
• [Presentation] Cerebellar white matter involvement in Alzheimer's disease: Diffusion tensor study. (2014)
  • Author(s): Taoka T, Miyasaka T, S Suthiphosuwan, Hori S, Sakamoto M, Kichikawa K
  • Organizer: Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Advanced diffusion imaging (2014)
  • Author(s): Taoka T
  • Organizer: Asia Oseania Congres of Radiology
  • Place of Presentation: Kobe
  • Year and Date: 2014-09-24 – 2014-09-28
  • Invited
• [Presentation] Quantitative imaging: imaging biomarker for brain disorder (2014)
  • Author(s): Taoka T
  • Organizer: XXth Symposium Neuroradiologicum
  • Place of Presentation: Istanbul
  • Year and Date: 2014-09-07 – 2014-09-12
  • Invited
• [Presentation] Diffusion tensor image for monitoring treatment effects (2014)
  • Author(s): Taoka T
  • Organizer: XXth Symposium Neuroradiologicum
  • Place of Presentation: Istanbul
  • Year and Date: 2014-09-07 – 2014-09-12
  • Invited
• [Presentation] 神経放射線から見た神経内科疾患 (2014)
  • Author(s): 田岡俊昭
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-05-22 – 2014-05-24
  • Invited
• [Presentation] Time course of diffusion kurtosis of cerebral infarctions in experimental model (2014)
  • Author(s): Taoka T、Fujioka M、Kashiwagi Y、Obata A、Rokugawa T、Abe K、Hori M、Masutani Y、Aoki S、Kichikawa K
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-13
• [Book] 新 頭部画像診断の勘ドコロ (2014)
  • Author(s): 田岡俊昭（分担）監修：高橋雅士 編集：前田正幸
  • Total Pages: 412
  • Publisher: MEDICAL VIEW