| Project/Area Number |
26461834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagoya University (2015-2016)
Nara Medical University (2014) |
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Principal Investigator |
Toshiaki Taoka 名古屋大学, 医学部附属病院, 病院准教授 (30305734)
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| Co-Investigator(Kenkyū-buntansha) |
吉川 公彦 奈良県立医科大学, 医学部, 教授 (10161506)
安野 史彦 奈良県立医科大学, 医学部, 准教授 (60373388)
岸本 年史 奈良県立医科大学, 医学部, 教授 (60201456)
和田 敬 奈良県立医科大学, 医学部, 助教 (90597098)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルツハイマー病 / 拡散MRI / 認知症 / ＭＲＩ / 拡散画像 / 拡散尖度画像 |
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| Outline of Final Research Achievements |
We analyzed cases of Alzheimer’s disease cases using Non-Gaussian diffusion images. The cases were also clinically evaluated including MMSE score and divided into Alzheimer’s disease group, mild cognitive impairment group and subjective cognitive impairment group. By using 3T MR imager, we acquired Non-Gaussian diffusion images and generated diffusion kurtosis images (DKI). DKI showed the decreased diffusion kurtosis in the uncinated fascicles in correlation with severity of the Alzheimer’s disease. That may indicate abnormality in the microstructure of the white matter in the uncinated fascicles which is a part of limbic system.
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