| Project/Area Number |
26461836
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
Sasaki Makoto 岩手医科大学, 医学部, 教授 (80205864)
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| Co-Investigator(Kenkyū-buntansha) |
寺山 靖夫 岩手医科大学, 医学部, 教授 (70146596)
山下 典生 岩手医科大学, 医学部, 講師 (90628455)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 超高磁場MRI / 磁気共鳴血管造影 / 流体解析 / 脳小血管病 / レンズ核線条体動脈 / 外側線条体動脈 |
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| Outline of Final Research Achievements |
We performed computational fluid dynamics (CFD) analysis of lenticulostriate arteries (LSAs) in patients with non-cardioembolic acute stroke patients using high-resolution magnetic resonance angiography at 7T. We found that wall shear stress (WSS) and other related metrics of the LSAs ipsilateral to the infarct in the LSA territory were lower than those of the contralateral LSAs. In contrast, these metrics of the proximal middle cerebral artery (pMCA) showed no substantial differences between ipsilateral and contralateral sides. Further, in the patients with infarct in the non-LSA territory, the metrics of LSA and pMCA showed no apparent laterality. These results suggest that impaired WSS and other CFD metrics of the perforating arteries are closely related to infarct generation by small vessel disease. The CFD method we established is considered a promising technique for evaluating progression of small vessel disease and risks of stroke events.
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