The early evaluation of the responsiveness in molecular target drugs and the visualization of liver function by the MRI molecular imaging.

• Project/Area Number: 26461844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Matsushima Shigeru 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (70444297)
• Research Collaborator: KINOSADA Yasutomi ; ERA Seiichi ; INABA Yoshitaka ; SATO Yozo ; MURATA Shinichi
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 癌 / 早期治療効果判定 / 分子画像 / 細胞密度画像 / 機能画像 / 磁気共鳴 / 磁化移動効果

Outline of Final Research Achievements

The purpose of this work is to perform the reactant early evaluation in molecular target drugs, and an exploitation of a surgery support liver-function imaging using MRI. To evaluate and compare the usefulness of equivalent cross-relaxation rate (ECR) imaging (ECRI) in the early prediction of the response of molecular target drugs treatments of colorectal liver metastases. In the response assessment to chemotherapy, the pretreatment ECR values were significantly higher in the responders group than in the non-responders group, and the 2 weeks after the ECR values were significantly lower. To evaluate posthepatectomy liver failure using gadoxetic acid-enhanced MRI with a measure of relative liver enhancement image (RLEI) on hepatobiliary phase images, thereby facilitating safe liver resection. This MRI examination method also provides morphological and functional information that can be used to optimize the preoperative selection of patients who can safely undergo liver resection.

Research Products

• [Journal Article] Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model (2017)
  • Author(s): Nishiofuku H, Tanaka T, Fukuoka Y, Sato T, Masada T, Tatsumoto S, Sho M, Yamato I, Yasuda S, Matsushima S, Takano M, Ohbayashi C, Kichikawa K.
  • Journal Title: J Vasc Interv Radiol Volume: 28 Pages: 457-464
  • DOI: 10.1016/j.jvir.2016.10.032
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative Evaluation of Posthepatectomy Liver Failure Using MRI-Based Liver Function Indices in Child-Pugh Class A. (2016)
  • Author(s): Matsushima S, Sato Y, Yamaura H, KatoM, Onoda Y, Murata S, Shimizu Y, Kinosada Y, Nishiofuku H, Inaba Y.
  • Journal Title: Open Journal of Radiology Volume: 6 Pages: 147-156
  • DOI: 10.4236/ojrad.2016.62022
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Equivalent cross-relaxation rate imaging and diffusion weighted imaging for early prediction of response to bevacizumab-containing treatment in colorectal liver metastases-preliminary study. (2016)
  • Author(s): Matsushima S, Sato T, Nishiofuku H, Sato Y, Murata S, Kinosada Y, Era S, Inaba Y.
  • Journal Title: Clinical Imaging Volume: 41 Pages: 1-6
  • DOI: 10.1016/j.clinimag.2016.08.013
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Preoperative estimation of future remnant liver function following portal vein embolization using relative enhancement on gadoxetic acid disodium-enhanced magnetic resonance imaging. (2015)
  • Author(s): Sato Y, Matsushima S, Inaba Y, Sano T, Yamaura H, Kato M, Shimizu Y, Senda Y, Ishiguchi T.
  • Journal Title: Korean J Radiol. Volume: 16(3) Pages: 523-530
  • DOI: 10.3348/kjr.2015.16.3.523
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New whole-body multimodality imaging of gastric cancer peritoneal metastasis combining fluorescence imaging with ICG-labeled antibody and MRI in mice. (2014)
  • Author(s): Ito A, Ito Y, Matsushima S, Tsuchida D, Ogasawara M, Hasegawa J, Misawa K, Kondo E, Kaneda N, Nakanishi H.
  • Journal Title: Gastric Cancer Volume: なし Pages: 497-507
  • DOI: 10.1007/s10120-013-0316-0
  • NAID: 40020216067
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors. (2014)
  • Author(s): Okuda H, Matsushima S, Sugiura H, Yamada K, Hamada S, Nishida Y, Ishiguro N.
  • Journal Title: Magn Reson Imaging Volume: 32(3) Pages: 206-210
  • DOI: 10.1016/j.mri.2013.12.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visualization of liver uptake function using the uptake contrast-enhanced ratio in hepatobiliary phase imaging. (2014)
  • Author(s): Matsushima S, Sato Y, Yamaura H, Kato M, Kinosada Y, Era S, Takahashi K, Inaba Y.
  • Journal Title: Magn Reson Imaging Volume: 32(6) Pages: 654-659
  • DOI: 10.1016/j.mri.2014.02.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The relative liver enhancement on hepatobiliary phase imaging for prediction of response to bevacizumab-containing treatment in liver metastases of colorectal cancer (2018)
  • Author(s): S Matsushima, S Murata, Y Sato, H Yamaura, Y Onoda, T Hasegawa, Y Kinosada, S Era, Y Inaba.
  • Organizer: 2018 European Congress of Radiology
  • Int'l Joint Research
• [Presentation] Equivalent cross-relaxation rate imaging and diffusion-weighted imaging for early prediction of response to bevacizumab-containing treatment in colorectal liver metastases. (2017)
  • Author(s): Matsushima S, Sato T, Nishiofuku H, Sato Y, Murata S, Kinosada Y, Era S, Inaba Y.
  • Organizer: 2017 European Congress of Radiology
  • Place of Presentation: Austria Center,Vienna, Austria
  • Year and Date: 2017-03-01
  • Int'l Joint Research
• [Presentation] Correlation of international normalized ratios after postoperative day 5 and MRI-based heterogeneous liver function indices in Child-pugh class A. (2016)
  • Author(s): S Matsushima, Y Sato, H Yamaura, Y Onoda, M Kato, S Murata, Y Kinosada, S Era, Y Inaba.
  • Organizer: 2016 European Congress of Radiology
  • Place of Presentation: Austria Center,Vienna, Austria
  • Year and Date: 2016-03-02
  • Int'l Joint Research
• [Presentation] Child-pugh class AにおけるICG TestとMRI-based liver function indicesの相関 (2015)
  • Author(s): 松島秀,佐藤洋造,山浦秀和,加藤弥菜,小野田結,村田慎一,紀ノ定保臣,惠良聖一,米澤佑司、小倉弘之,稲葉吉隆
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京都）
  • Year and Date: 2015-09-11
• [Presentation] Prediction of posthepatectomy liver failure using the coefficient variation of relative liver enhancement on hepatobiliary phase images. (2015)
  • Author(s): Matsushima S, Sato Y, Yamaura H, Kato M, Murata S, Kinosada Y, Era S, Yonezawa Y, Ogura H, Inaba Y
  • Organizer: 2015 European Congress of Radiology
  • Place of Presentation: Austria Center,Vienna, Austria
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] Preoperative evaluation of future remnant liver function by the coefficient variation of contrast enhanced ratio in hepatocellular image (2014)
  • Author(s): Matsushima S, Sato Y, Yamaura H, Kato M, Kinosada Y, Era S, Takahashi K, Inaba Y
  • Organizer: Radiological Society of North America 100 nd Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] 肝細胞画像の造影率を用いた残肝機能の術前評価 (2014)
  • Author(s): 松島秀, 佐藤洋造,山浦秀和,加藤弥菜,川田紘資,村田慎一,紀ノ定保臣,惠良聖一,米澤佑司、小倉弘之,稲葉吉隆
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: ホテルグラヴィア京都
  • Year and Date: 2014-09-10 – 2014-09-12