The molecular mechanism of radiation-induced acceleration of atherosclerosis
Project/Area Number |
26461852
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Fukushima Medical University (2016) Hiroshima University (2014-2015) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
石田 万里 広島大学, 医歯薬保健学研究院(医), 講師 (30359898)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | DNA損傷 / 動脈硬化 / 放射線被ばく / 放射線 / ゲノム障害 |
Outline of Final Research Achievements |
It has been well recognized that radiotherapy increases the risk of atherosclerotic cardiovascular disease. The object of this study was to clarify the mechanism of radiation-induced acceleration of atherosclerosis. Thoracic aorta of apoE-deficient (apoE-KO) mice were irradiated with the dose of 10Gy and kept on a normal chow diet for 8 weeks. The plaque area was significantly increased in aortic roots of irradiated apoE-KO mice compared with control mice. Infiltration of inflammatory cells and hemorrhage was observed in the plaque. Additionally, immunohistochemical study revealed that gamma-H2AX and phospho-ATM staining were increased in the plaque of irradiated apoE-KO mice. These results suggest that accumulation of DNA damage and activation of DNA damage response is involved in the mechanism of radiation-induced acceleration of atherosclerosis.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms.2016
Author(s)
Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M.
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Journal Title
Related Report
Peer Reviewed / Open Access
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