Molecular imaging of gastrointestinal cancer with PET proliferation tracer
| Project/Area Number |
26461854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
Ono Yuko 香川大学, 医学部附属病院, 講師 (10604952)
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| Co-Investigator(Kenkyū-buntansha) |
山本 由佳 香川大学, 医学部, 准教授 (30335872)
西山 佳宏 香川大学, 医学部, 教授 (50263900)
岡野 圭一 香川大学, 医学部附属病院, 准教授 (20314916)
豊原 潤 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50425659)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 核酸誘導体 / PET / 分子イメージング / 消化器癌 / C-11 4DST / 11C-4DST |
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| Outline of Final Research Achievements |
4DST has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to investigate the feasibility of 4DST PET/CT for the detection of gastrointestinal cancer, in comparison with FDG PET/CT, and determined the degree of correlation between two radiotracers and proliferative activity as indicated by the Ki-67 index. Gastrointestinal cancer were detected by both 4DST and FDG PET/CT studies. A significant correlation was observed between 4DST SUV and FDG SUV. A significant correlation was observed between 4DST SUV and Ki-67 index and for FDG SUV. These preliminary results indicate that 4DST PET/CT seems to be useful in detecting gastrointestinal cancer and in the noninvasive assessment of proliferation, as similar as FDG PET/CT.
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Report
(4 results)
Research Products
(4 results)
