research on usefulness of myocardial uptake index on stress myocardial perfusion SPECT

• Project/Area Number: 26461858
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Tomiguchi Seiji 熊本大学, 大学院生命科学研究部(保), 教授 (20172182)
• Co-Investigator(Renkei-kenkyūsha): ITO Shigeki 熊本大学, 大学院生命科学研究部(保), 教授 (80402395) ; SHIRAISHI Shinya 熊本大学, 大学院生命科学研究部, 助教 (50433008) ; KAWANO Hiroaki 熊本大学, 大学院生命科学研究部(保), 教授 (10305013)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心筋摂取率 / 心筋血流 / SPECT / Tl-201 / 虚血性心疾患 / 半導体検出器 / Tc-99m

Outline of Final Research Achievements

The Aim of this study is to clarify the clinical usefulness of Tl-201 myocardial uptake index(MUI) in adenosine stress Tl-201 Myocardial perfusion SPECT imaging using a CZT camera. MUI was calculated by dividing radioactivity of whole left ventricular myocardium extracted from myocardial contour by injection dose. Relationship between MUI and coronary arterial stenosis was evaluated in 51 patients without visual perfusion abnormality on stress image. The mean MUI value in 32 patients with coronary arterial stenosis was significantly lower than that in 8 patients without coronary arterial stenosis (normal subjects) and that in 11 patients with low risk of coronary arterial stenosis was not significantly different form normal subjects. In conclusion, adding MUI measurements to visual assessment is suggested to be useful for the diagnosis of coronary arterial disease.

Research Products

• [Journal Article] Ｕｓｅｆｕｌｎｅｓｓ of the Chang attenuation correction method with use of a CT-based μ map by FBP reconstruction in (201)Tl SPECT-MPI. (2015)
  • Author(s): Nakamura Y。Tomiguchi S
  • Journal Title: Ann Nucl Med Volume: 29 Issue: 5 Pages: 467-473
  • DOI: 10.1007/s12149-015-0972-8
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 循環器病の核医学 (2015)
  • Author(s): 冨口 静二
  • Journal Title: レジデント Volume: ８ Pages: 31-40
• [Journal Article] Prediction of Left Main or 3-Vessel Disease Using Myocardial Perfusion Reserve on Dynamic Thallium-201 Single-Photon Emission Computed Tomography With a Semiconductor Gamma Camera (2015)
  • Author(s): Shiraishi S, Sakamoto F, Tsuda N, Yoshida M, Tomiguchi S, Utsunomiya D, Ogawa H, Yamashita Y.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 623-631
  • DOI: 10.1253/circj.CJ-14-0932
  • NAID: 130004927121
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Presentation] Influence of CT attenuation correction on image quality of reconstructed SPECT image on stress Thallium-201 SPECT-MPI using CZT detector SPECT device (2016)
  • Author(s): S.Kudo,R. Matsuda, S. Tomiguchi
  • Organizer: 29th Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Balcerona, Spain
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] Clinical usefulness of 201Tl myocardial uptake at stress with 201Tl SPECT-MPI on a Cadmium Zinc Telluride(CZT) camera (2016)
  • Author(s): R. Matsuda, S.Tomiguchi, S.KUdo, S. Shiraishi,Y. Yamashita
  • Organizer: 29th Annual ongress of the European Association of Nuclear Medicine
  • Place of Presentation: Balcerona, Spain
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] 半導体型SPECT装置を用いた201Tl負荷心筋血流SPECT検査における心筋摂取率 (2016)
  • Author(s): 松田 凌、冨口 静二 他
  • Organizer: 第８２回日本心臓血管放射線研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-30
• [Presentation] 半導体型SPECT装置を用いた心筋血流定量解析のためのTAC至適収集時間間隔の検討 (2015)
  • Author(s): 大串 岳、冨口 静二 他
  • Organizer: 第３５回日本核医学技術学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-05
• [Presentation] 半導体型SPECT装置を用いた201Tl心筋血流SPECT検査におけるCT減弱補正の有用性に関する検討 (2015)
  • Author(s): 工藤 翔吾、冨口 静二 他
  • Organizer: 第３５回日本核医学技術学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-05
• [Presentation] Appropriate time interval of dynamic 201Tl SPECT-MPI data acquisition for quantitative myocardial blood flow analysis on cardiac dedicated ultrafast SPECT camera (2015)
  • Author(s): G. Ogushi, S. Tomiguchi, et al.
  • Organizer: 28th Annual EANM Congress
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Differences in Extraction Accuracy Using Different Automated Myocardium Extraction Algorithm (2014)
  • Author(s): M. Tanaka, R. Kimoto, K. Nagahiro, G. Ogushi, S. Shiraishi, S. Tomiguchi
  • Organizer: 27th Annual EANM Congress 2014
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Evaluation of optimal acquisition time and image quality for half-dose 201Tl SPECT-MPI using cardiac dedicated ultrafast SPECT camera (2014)
  • Author(s): R. Kimoto, K. Nagahiro, M. Tanaka, G. Ogushi, S. Tomiguchi, N. Katsda, S. Shiraishi, Y. Yamashita
  • Organizer: 27th Annual EANM Congress 2014
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Usefulness of Novel PVE Correction Method for Quantitative Assessment of Myocardial SPECT (2014)
  • Author(s): K. Nagahiro, R. Kimoto, M. Tanaka, G. Ogushi, S. Tomiguchi, N. Katsuda, S. Shiraishi, Y. Yamashita
  • Organizer: 27th Annual EANM Congress 2014
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] 心臓専用半導体SPECT装置における幾何学的配置が再構成画像に与える影響 (2014)
  • Author(s): 大串岳、木本涼太、田中政行、長廣和也、冨口静二
  • Organizer: 第79回日本心臓血管放射線研究会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-07-05 – 2014-07-06