Quantification and validation of myocardial blood flow and flow reserve using a semiconductor gamma camera;

• Project/Area Number: 26461859
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Shiraishi Shinya 熊本大学, 大学院生命科学研究部(医), 助教 (50433008)
• Co-Investigator(Kenkyū-buntansha): 冨口 静二 熊本大学, 大学院生命科学研究部(保), 教授 (20172182)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 心筋血流定量 / 心筋血流予備能 / Tl-201 / 半導体検出器 / SPECT / 心筋血流量定量 / Myocardial perfusion / Semiconductor γ-camera / Thallium-201 / Balanced ischemia / Three-vessel disease

Outline of Final Research Achievements

Absolute myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) mesurements yields incremental diagnostic and prognostic information on relative perfusion alone.We compared various clinical risk factors in patients with coronary artery disease (CAD) to validate the MBF or MPR by 201Tl cardiac dynamic SPECT using a cadmium zinc telluride (CZT) camera.
The quantification of the MBF and MPR on dynamic SPECT obtained with the aid of a CZT camera is clinically feasible. We could prove clinical risk factors for rest MBF, stress MBF, and MPR.

Research Products

• [Journal Article] Prediction of Left Main or 3-Vessel Disease Using Myocardial Perfusion Reserve on Dynamic Thallium-201 Single-Photon Emission Computed Tomography With a Semiconductor Gamma Camera (2015)
  • Author(s): Shiraishi S, Sakamoto F, Tsuda N, Yoshida M, Tomiguchi S, Utsunomiya D, Ogawa H, Yamashita Y.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 623-631
  • DOI: 10.1253/circj.CJ-14-0932
  • NAID: 130004927121
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Presentation] Comparison of MBF and MFR by dynamic SPECT with clinical risk factors of CAD in patients with normal MPS (2017)
  • Author(s): Shinya Shiraishi
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2017-04-13
  • Int'l Joint Research
• [Presentation] 半導体 SPECT を用いた心筋血流定量による summed stress score 正常例における冠動脈多枝病変の検出 (2016)
  • Author(s): 白石慎哉
  • Organizer: 日本核医学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] 半導体 SPECT による心筋血流定量法の試み (2016)
  • Author(s): 白石慎哉
  • Organizer: 九州心臓核研修会
  • Place of Presentation: 博多JRシティ
  • Int'l Joint Research
• [Presentation] 左主幹部病変及び3枝病変の予測における半導体検出器を用いた心筋血流予備能の有用性 (2014)
  • Author(s): 津田紀子、白石慎哉、坂本史、吉田守克、冨口静二、山下康行
  • Organizer: 第54回日本核医学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-11-06 – 2014-11-08