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Development of fully automatic quantification methods in nuclear medicine examinations for Parkinson's disease and Parkinson-plus syndromes diagnosis

Research Project

Project/Area Number 26461860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

Ito Shigeki  熊本大学, 大学院生命科学研究部(保), 教授 (80402395)

Research Collaborator OFUJI Asato  
YAMASHITA Kosuke  
OKUMIYA Shintaro  
KAMIYA Yoshito  
TOMIMATSU Taeko  
NAGAOKA Rieko  
KANENAWA Tkayuki  
OTA Satoru  
TANAKA Yudai  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords定量 / 全自動 / パーキンソン病 / 線条体 / 画像解析 / 全自動定量 / 認知症 / レヴィ小体病 / 鑑別能 / イオフルパン / ベンジルグアニジン / SPECT / パーキンソン / 放射能定量 / レヴィ小体型認知症
Outline of Final Research Achievements

New fully automatic quantification methods using Iodine-123 metaiodobenzylguanidine (123I-MIBG) and Iodine-123 Iofulpane (123I-Ioflupane) have been developed by image analysis according to the pharmacokinetics of 123I-MIBG and 123I-Ioflupane, respectively. The diagnostic accuracy of the new fully automatic methods were superior to the current routine methods. Additionally, the new fully automatic methods improved the repeatability and reproducibility. These methods could be applied as useful and stable methods in routine clinical studies.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease2017

    • Author(s)
      Yoshito Kamiya; Satoru Ota; Shintaro Okumiya; Kosuke Yamashita; Akihiro Takaki; Shigeki Ito
    • Journal Title

      Asia Oceania Journal of Nuclear Medicine & Biology

      Volume: 5 Pages: 37-43

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fully automatic input function determination program for simple noninvasive <sup>123</sup>I-IMP microsphere cerebral blood flow quantification method2016

    • Author(s)
      Yamashita K, Uchiyama Y, Ofuji A, Mimura H, Okumiya S, Takaki A, Sone T, Ito S.
    • Journal Title

      Physica Medica

      Volume: 32 Issue: 9 Pages: 1180

    • DOI

      10.1016/j.ejmp.2016.08.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a simple non-invasive microsphere quantification method for cerebral blood flow using I-123-IMP2016

    • Author(s)
      Ofuji A, Mimura H, Yamashita K, Takaki A, Sone T, Ito S.
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 30 Issue: 3 Pages: 242

    • DOI

      10.1007/s12149-015-1053-8

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 123I-IMPグラフ解析定量法の換算式の再構築2015

    • Author(s)
      富松 多栄子, 山下 康輔, 大藤 亜里, 長岡 里江子, 宮島 隆一, 有迫 哲朗, 井芹 卓見, 伊藤 茂樹
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 71 Issue: 7 Pages: 612-620

    • DOI

      10.6009/jjrt.2015_jsrt_71.7.612

    • NAID

      130005087914

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of an Automatic Quantitative Method for Measuring Regional Cerebral Blood Flow Using 99mTc Ethyl Cysteinate Dimer Brain Uptake Ratio2015

    • Author(s)
      Rieko Nagaoka, Asato Ofuji, Kosuke Yamashita, Taeko Tomimatsu, Shinnichi Orita, Akihiro Takaki, Yoshikazu Uchiyama, Shigeki Ito
    • Journal Title

      Asia Oceania J Nucl Med Biol.

      Volume: 3 Pages: 77-82

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] レヴィ小体病診断のための早期・後期画像による123I-MIBG心臓摂取率法の評価2016

    • Author(s)
      米園隆稀,神谷嘉人, 大田哲,田中雄大,伊藤茂樹
    • Organizer
      第11回九州放射線医療技術学術大会
    • Place of Presentation
      別府国際コンベンションセンター
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 123I-MIBG Planar Imageを用いた定量法の開発2016

    • Author(s)
      大田哲,神谷嘉人,奥宮真太郎,的場隆亮, 高木昭浩,伊藤茂樹
    • Organizer
      第36回日本核医学技術学会総会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] レヴィ小体病評価のための 3次元123I-MIBG 画像による摂取指標2016

    • Author(s)
      田中雄大、神谷嘉人、 大田哲、高木昭浩、伊藤茂樹
    • Organizer
      第36回日本核医学技術学会総会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] I-123-ioflupane定量法の開発2016

    • Author(s)
      金縄貴之,奥宮 真太郎,伊藤茂樹
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 線条体ドパミントランスポーターイメージングにおける新たな特異的結合比算出法の構築2015

    • Author(s)
      奥宮真太郎, 金縄貴之, 伊藤茂樹
    • Organizer
      第35回日本核医学技術学会総会学術大会
    • Place of Presentation
      ハイアットリージェンシー東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 123I-Ioflupane定量法開発のための逐次近似法条件と検出下限の関係2015

    • Author(s)
      北村 燎平, 伊藤 茂樹
    • Organizer
      第10回九州放射線医療技術学術大会
    • Place of Presentation
      宮崎観光ホテル
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 123I-Ioflupane定量法開発に向けた関心領域および逐次近似法最適条件の決定2015

    • Author(s)
      田中 雄大,伊藤 茂樹
    • Organizer
      第10回九州放射線医療技術学術大会
    • Place of Presentation
      宮崎観光ホテル
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] MIBGシンチにおける早期と後期像における摂取率指標の検討2015

    • Author(s)
      的場 隆亮, 神谷 嘉人,奥宮 真太郎, 高木 昭浩,伊藤 茂樹
    • Organizer
      第10回九州放射線医療技術学術大会
    • Place of Presentation
      宮崎観光ホテル
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 123I-MIBG心筋摂取指標算出のための肺野自動描出プログラムの開発2015

    • Author(s)
      江崎 匠 神谷 嘉人,奥宮 真太郎, 高木 昭浩,伊藤 茂樹
    • Organizer
      第10回九州放射線医療技術学術大会
    • Place of Presentation
      宮崎観光ホテル
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 心筋MIBGシンチ2次元画像解析を用いる認知症診断のための定量法の開発2015

    • Author(s)
      大田 哲,神谷 嘉人,奥宮 真太郎, 高木 昭浩,伊藤 茂樹
    • Organizer
      第10回九州放射線医療技術学術大会
    • Place of Presentation
      宮崎観光ホテル
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of a new quantification method using the I-123 MIBG myocardial single photon emission tomography2015

    • Author(s)
      Yoshito Kamiya, Shintaro Okumiya, Akihiro Takaki, Kosuke Yamashita, Shigeki Ito
    • Organizer
      EANM'15, 28th Annual EANM Congress of the European Association of Nuclear Medicine 2015
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a new quantification method of dopamine transporter density with 123I-ioflupane2015

    • Author(s)
      Shintaro Okumiya, Asato Ofuji, Shigeki Ito
    • Organizer
      EANM'15, 28th Annual EANM Congress of the European Association of Nuclear Medicine 2015
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 最新の非侵襲脳血流定量法2015

    • Author(s)
      伊藤 茂樹
    • Organizer
      第29回 日本核医学技術学会 九州地方会学術大会
    • Place of Presentation
      熊本市国際交流会館
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 123I-Ioflupaneを用いる正常体定量に向けた二次元逐次近似法の適2014

    • Author(s)
      奥宮真太郎、伊藤茂樹
    • Organizer
      第33回日本核医学技術学会総会学術大会
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 123I-Ioflupane線条体定量法開発に向けた関心領域決定法2014

    • Author(s)
      塩村彩華、伊藤茂樹
    • Organizer
      第9回九州放射線医療技術学術大会 (福岡県北九州市)
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 123I-Ioflupane線条体定量法における二次元逐次近似法画像再構成条件2014

    • Author(s)
      江口まりこ、伊藤茂樹
    • Organizer
      第9回九州放射線医療技術学術大会 (福岡県北九州市)
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of a fully automatic input function determination program in 123I-IMP non-invasive cerebral blood flow quantification2014

    • Author(s)
      Kosuke Yamashita, Shigeki Ito
    • Organizer
      Annual Congress of the European Association of Nuclear Medcine 2014 (Gothenburg, Sweaden)
    • Place of Presentation
      Gothenburg, Sweaden
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 核医学脳血流定量法解析法の基礎から最新技術まで2014

    • Author(s)
      伊藤茂樹
    • Organizer
      第30回 日本診療放射線技師学術大会
    • Place of Presentation
      別府国際コンベンションセンター B-Con Plaza
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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