Clinical research for EMSB to obatain PET/SPECT images of Amyloidosisin AD and FAP
| Project/Area Number |
26461861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
Tomiyoshi Katsumi 熊本大学, 大学院生命科学研究部(保), 教授 (60188802)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 全身性アミロイド―シス / 標識薬剤 / 18FEFSB / 最適合成条件 / 放射性標識薬剤 / 125I-EISB / 最適反応時間 / アミロイド / アミロイドーシス / 18F-EISB / コンゴーレッド / 組織化学的分析 / 偏光顕微鏡 / 標識合成 / ラジオアイソトープ / ＳＰＥＣＴ / １２５Ｉ / １２３Ｉ / ＥＩＳＢ / ＥＭＳＢ / 動物実験 / アルツハイマー病（ＡＤ） / 123I-EISB / 動物用SPECT/CTシステム / 18F-EFSB / ヨード標識合成 / 体内分布 / IP |
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| Outline of Final Research Achievements |
we made a precursor EMSB and 19F-EFSB labeled stable isotope fluorine on EMSB to develop a new imaging probe18F-EFSB that detects systemic amyloidosis by PET examination. As a result of histochemical analysis, 19F-EFSB specifically accumulated in all disease type amyloid. 18F-EFSB was efficiently labeled with a radiochemical purity of 81.7 ± 5.1%(n=3) by reaction at 200 degree. for 5 minutes.
We also determined the optimal synthesis time and clarify stability of 125I-EISB in saline and human serum, respectively. As a result,high radioactive purity 95.88±3.19% was obtained in 10 minutes by our synthesis and the radiochemical purity was97.83±1.40% (n=6) applying our purification system.
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Report
(5 results)
Research Products
(21 results)
