Experimental study of selective portal vein embolization for nonalcoholic steatohepatitis in rabbit model

Research Project

Project/Area Number	26461865
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Kagoshima University
Principal Investigator	hayashi sadao 鹿児島大学, 医歯学域附属病院, 助教 (10549918)
Co-Investigator(Kenkyū-buntansha)	東美智代鹿児島大学, 医歯学域医学系, 准教授 (60315405)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	門脈塞栓術 / 脂肪肝 / 門脈塞栓
Outline of Final Research Achievements	After portal embolization, sinusoidal obstruction grade was significantly worsen in remnant liver lobe of rabbit NAFLD model. SMA staining area was significantly larger in each remnant liver lobe compared with normal control and NAFLD control liver. which means Portal vein embolization(PVE) induced the fibrotic change in not only embolized liver lobe and remnant lobe. These findings suggest that PVE induce the liver damage in remnant lobe. particular in fatty change liver, it was considered that fatty change and PVE induce sinusoid obstruction. We think sinusoid obstruction and liver fibrosis in future remnant liver would be the risk of unexpected fatal liver damage cannot be excluded in the patients with NAFLD after PVE.