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Experimental study of selective portal vein embolization for nonalcoholic steatohepatitis in rabbit model

Research Project

Project/Area Number 26461865
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKagoshima University

Principal Investigator

hayashi sadao  鹿児島大学, 医歯学域附属病院, 助教 (10549918)

Co-Investigator(Kenkyū-buntansha) 東 美智代  鹿児島大学, 医歯学域医学系, 准教授 (60315405)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords門脈塞栓術 / 脂肪肝 / 門脈塞栓
Outline of Final Research Achievements

After portal embolization, sinusoidal obstruction grade was significantly worsen in remnant liver lobe of rabbit NAFLD model. SMA staining area was significantly larger in each remnant liver lobe compared with normal control and NAFLD control liver. which means Portal vein embolization(PVE) induced the fibrotic change in not only embolized liver lobe and remnant lobe.
These findings suggest that PVE induce the liver damage in remnant lobe. particular in fatty change liver, it was considered that fatty change and PVE induce sinusoid obstruction. We think sinusoid obstruction and liver fibrosis in future remnant liver would be the risk of unexpected fatal liver damage cannot be excluded in the patients with NAFLD after PVE.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] Experimental study of selective portal vein embolization for nonalcoholic steatohepatitis in rabbit model2014

    • Author(s)
      林 完勇
    • Organizer
      APCCVIR
    • Place of Presentation
      singapore(singapore)
    • Year and Date
      2014-05-15 – 2014-05-18
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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