Percutaneous cryoablation for benign prostatic hyperplasia: analysis of effects on adjacent organs and surrounding tissues

• Project/Area Number: 26461867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Tanaka Osamu 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (70317246)
• Co-Investigator(Kenkyū-buntansha): 一条 祐輔 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10714686) ; 田中 匡 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60750544) ; 林 奈津子 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (70736173) ; 三浦 寛司 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20607593) ; 岡本 芳晴 鳥取大学, 農学部, 教授 (50194410)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 凍結療法 / 前立腺 / IVR

Outline of Final Research Achievements

We conducted fundamental research on cryotherapy that is expected to be applied to benign prostatic hyperplasia. Under general anesthesia, a cryoablation to normal prostate was performed for six dogs. MRI was performed before and after freezing, and changes in prostate volume and histopathological changes after cryotherapy were examined. Cryotherapy for the prostate was found to cause severe hemorrhagic necrosis. In addition, when the urethra was in contact with the freezing region, the urethral epithelium was pathologically histologically dropped, but it was impossible to evaluate urethral damage during MRI.

Research Products

• [Journal Article] Successful Angioplasty of a Hepatic Vena Caval Branch in a Patient with Budd-Chiari Syndrome Due to Occlusion of the Three Major Hepatic Veins (2017)
  • Author(s): Yamashita M, Hayashi N, Takeuchi Y, Tanaka O, Yamada K
  • Journal Title: Interventional Radiology Volume: 2 Issue: 3 Pages: 85-88
  • DOI: 10.22575/interventionalradiology.2017-0007
  • NAID: 130006196185
  • ISSN: 2432-0935
  • Peer Reviewed
• [Journal Article] CT findings after lipiodol marking performed before video-assisted thoracoscopic surgery for small pulmonary nodules. (2016)
  • Author(s): Miura H, Tanaka O, Ichijo Y, et al
  • Journal Title: Acta Radiol Volume: 57 Issue: 3 Pages: 303-310
  • DOI: 10.1177/0284185115576047
  • Peer Reviewed
• [Journal Article] The efficacy of radio-frequency ablation (RFA) for metastatic lung or liver tumors of male germ cell tumors as an alternative minimally invasive therapy after salvage chemotherapy (2015)
  • Author(s): Naya Y, Nakamura T, Oishi M, Ueda T, Nakanishi H, Naitoh Y, Hongo F, Kamoi K, Okihara K, Tanaka O, Yamagami T, Yamada K, Miki T
  • Journal Title: Int J Clin Oncol Volume: 20 Issue: 6 Pages: 1192-1197
  • DOI: 10.1007/s10147-015-0824-5
  • Peer Reviewed
• [Journal Article] 3年間の経過観察後に回収可能であった中心静脈カテーテル離断の1例 (2015)
  • Author(s): 中迫由里、田中治、他
  • Journal Title: 臨床放射線 Volume: 60 Pages: 337-339
  • Peer Reviewed
• [Presentation] Lipiodol retension of hypervascular renal tumors in lipiodol marking before renal cryoablation (2018)
  • Author(s): Ichijo Y, Miura H, Hirota T, Tanaka T, Yoshikawa T, Yamahana Y, Yamashita M, Tsuji Y, Saruya S, Tanaka O, Yamada K
  • Organizer: JSIR & ISIR 2018
  • Int'l Joint Research
• [Presentation] Evaluation of prostate and urethra after cryotherapy in normal canine model (2018)
  • Author(s): Miura H, Tanaka O, Yamahana Y, Yamashita M, Yosikawa T, Tsuji Y, Tanaka T, Saruya S, Hirota T, Yamada K, Okamoto Y
  • Organizer: JSIR & ISIR 2018
  • Int'l Joint Research
• [Presentation] Percutaneous balloon angioplasty of a narrowed accessory hepatic vein (AcHV) in Budd-Chiari syndrome (BCS). (2015)
  • Author(s): Yamashita M, Hayashi N, Ichijo Y, Tanaka O, et al.
  • Organizer: CIRSE 2015
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Initial experience of CT-guided cryoablation for malignant renal neoplasms (2014)
  • Author(s): Tanaka O, Ichijyo Y, Miura H, Hayashi N, et al.
  • Organizer: The 12th Balkan Congress of Radiology
  • Place of Presentation: イスタンブール/トルコ
  • Year and Date: 2014-10-16 – 2014-10-19
  • Invited
• [Presentation] 正常豚肺における媒体注入下ラジオ波焼灼療法；microbubble発生の検討 (2014)
  • Author(s): 田中匡、田中治、他
  • Organizer: 第43回日本IVR学会総会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-06-05 – 2014-06-07
• [Presentation] 当院における経皮的腎腫瘍凍結療法の初期経験の報告 (2014)
  • Author(s): 一条祐輔、田中治、他
  • Organizer: 第43回日本IVR学会総会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-06-05 – 2014-06-07
• [Presentation] 不完全凍結による腫瘍増殖への影響；腎癌臨床例での検討 (2014)
  • Author(s): 三浦寛司、田中治、他
  • Organizer: 第43回日本IVR学会総会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-06-05 – 2014-06-07
• [Presentation] Initial experience of preoperative transcatheter arterial lipiodol marking for CT-guided cryoablation for small renal tumors (2014)
  • Author(s): Asai S, Tanaka O, et al.
  • Organizer: The 73th Annual meeting of the Japanese Radiological Society
  • Place of Presentation: Yokohama/Japan
  • Year and Date: 2014-04-10 – 2014-04-13
• [Book] 画像診断+IVRヒヤリハット (2015)
  • Author(s): 田中治、他
  • Total Pages: 281
  • Publisher: 南江堂