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Development of TACE using drug eluting microspheres for HCC

Research Project

Project/Area Number 26461868
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNara Medical University

Principal Investigator

Sakaguchi Hiroshi  奈良県立医科大学, 医学部, 非常勤講師 (10205734)

Co-Investigator(Kenkyū-buntansha) 平井 都始子  奈良県立医科大学, 医学部, 病院教授 (00208802)
田中 利洋  奈良県立医科大学, 医学部, 准教授 (70326338)
Co-Investigator(Renkei-kenkyūsha) HIRAI Toshiko  奈良県立医科大学, 医学部, 病院教授 (00208802)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordschemoemboliztaion / liver cancer / マイクロスフィア / ビーズ / インターベンショナルラジオロジー(IVR) / インターベンショナルラジオロジー(IVR)
Outline of Final Research Achievements

Transarterial chemoembolization (TACE) is widely used for unresectable hepatocellular carcinoma. Recently, TACE using microspheres has been developed. In this study, in a rabbit liver tumor model, TACE using microspheres was evaluated. When comparing TACE using starch microspheres mixed with cisplatin arterial infusion, TACE was superior in the tumor drug concentration and the efficacy. In addition, microspheres dissolved within 24 hours.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model.2017

    • Author(s)
      Sato T, Tanaka T, Nishiofuku H, Fukuoka Y, Sakaguchi H, Masada T, Tatsumoto S, Marugami N, Takano M, Yamato I, Sho M, Ohbayashi C, Hirai T, Kichikawa K.
    • Journal Title

      Cardiovasc Intervent Radiol

      Volume: 40 Issue: 3 Pages: 438-444

    • DOI

      10.1007/s00270-016-1512-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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