Development of TACE using drug eluting microspheres for HCC

Research Project

Project/Area Number	26461868
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Nara Medical University
Principal Investigator	Sakaguchi Hiroshi 奈良県立医科大学, 医学部, 非常勤講師 (10205734)
Co-Investigator(Kenkyū-buntansha)	平井都始子奈良県立医科大学, 医学部, 病院教授 (00208802) 田中利洋奈良県立医科大学, 医学部, 准教授 (70326338)
Co-Investigator(Renkei-kenkyūsha)	HIRAI Toshiko 奈良県立医科大学, 医学部, 病院教授 (00208802)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	chemoemboliztaion / liver cancer / マイクロスフィア / ビーズ / インターベンショナルラジオロジー（IVR） / インターベンショナルラジオロジー（ＩＶＲ）
Outline of Final Research Achievements	Transarterial chemoembolization (TACE) is widely used for unresectable hepatocellular carcinoma. Recently, TACE using microspheres has been developed. In this study, in a rabbit liver tumor model, TACE using microspheres was evaluated. When comparing TACE using starch microspheres mixed with cisplatin arterial infusion, TACE was superior in the tumor drug concentration and the efficacy. In addition, microspheres dissolved within 24 hours.