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A study of tumor diagnosis by whole-body dynamic imaging using positron emission tomography with continuous bed motion.

Research Project

Project/Area Number 26461869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionJuntendo University (2016-2017)
Keio University (2014-2015)

Principal Investigator

Murakami Koji  順天堂大学, 医学部, 教授 (50200267)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsポジトロンCT / PET/CT / ダイナミック撮像 / FDG / 連続寝台移動 / 腫瘍診断 / 時間放射能曲線 / 生理的集積 / PET/CT装置 / FDG-PET / ダイナミック収集 / 悪性腫瘍 / SUV / 画像処理
Outline of Final Research Achievements

Conventional PET image is usually obtained as “static” distribution of radiopharmaceuticals in the body. We newly developed “whole-body dynamic imaging (WBDI)” protocol using continuous bed motion PET scanner that enable us to analyze a change of distribution of radiopharmaceuticals according to time. The object is to discuss whether the method may useful for cancer diagnosis. At first, phantom study was performed to establish a feasible protocol to acquire WBDI, followed by studying for clinical application. In result, no significant difference was found for qualitative diagnosis using WBDI as long as image acquisition was started 1hour post injection, though it may effective for differentiate physiological uptake from pathological accumulation.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (47 results)

All 2018 2017 2016 2015 2014

All Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (25 results) (of which Int'l Joint Research: 4 results,  Invited: 9 results) Book (1 results)

  • [Journal Article] FDG-PETが有用であったPSA陰性前立腺癌の2例2018

    • Author(s)
      宇田川 剛史, 岡田 慎悟, 山城 雄貴, 中西 淳, 村上 康二
    • Journal Title

      臨床核医学

      Volume: 51 Pages: 2-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人健常対象者における年齢と性別の[123I]FP-CIT SPECTへの影響2017

    • Author(s)
      山本 英男, 竹元 省太, 軽部 修平, 山城 雄貴, 中西 敦, 村上 康二
    • Journal Title

      臨床放射線

      Volume: 62 Pages: 1063-1069

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【腎泌尿器疾患の画像診断の進歩】 腫瘍同定に対するPETの進歩2017

    • Author(s)
      村上康二
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 6 Pages: 30-36

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 頭頸部癌の検査・診断 核医学画像診断の現状と将来展望2017

    • Author(s)
      村上康二
    • Journal Title

      日本臨床

      Volume: 75 Pages: 262-267

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 【骨格筋の画像診断】 PETによる骨格筋の病態の評価2017

    • Author(s)
      村上康二
    • Journal Title

      臨床画像

      Volume: 33 Pages: 527-536

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Inter-evaluator heterogeneity of clinical diagnosis for locally advanced esophageal squamous cell carcinoma.2017

    • Author(s)
      Hamamoto Y, Nojima M, Aoki Y, Suzuki T, Kawasaki K, Hirata K, Sukawa Y, Kasuga A, Kawakubo H, Takeuchi H, Murakami K, Takaishi H, Kanai T, Kitagawa Y.
    • Journal Title

      Esophagus

      Volume: 14 Issue: 4 Pages: 324-332

    • DOI

      10.1007/s10388-017-0580-x

    • NAID

      40021339501

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The psychological impact of disclosing amyloid status to Japanese elderly: a preliminary study on asymptomatic patients with subjective cognitive decline2017

    • Author(s)
      Wake Taisei、Tabuchi Hajime、Funaki Kei、Ito Daisuke、Yamagata Bun、Yoshizaki Takahito、Kameyama Masashi、Nakahara Tadaki、Murakami Koji、Jinzaki Masahiro、Mimura Masaru
    • Journal Title

      International Psychogeriatrics

      Volume: Epub ahead of print Issue: 5 Pages: 1-5

    • DOI

      10.1017/s1041610217002204

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Limited Identification of Dual-time-point Positron Emission Tomography/Computed Tomography in Advanced Colorectal Neoplasms2017

    • Author(s)
      Kashiwagi K, Nakazato Y, Arai M, Iwasaki E, Naganuma M, Inoue N, Iwao Y, Ogata H, Murakami K, Kanai T.
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 11 Pages: 1287-1292

    • DOI

      10.2169/internalmedicine.56.8037

    • NAID

      130006857225

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related effects and gender differences in Japanese healthy controls for [123I]FP^CIT SPECT2017

    • Author(s)
      Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki
    • Journal Title

      Ann Nucl Med

      Volume: 未定 Issue: 5 Pages: 407-412

    • DOI

      10.1007/s12149-017-1168-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely Low Prevalence of Amyloid Positron Emission Tomography Positivity in Parkinson's Disease without Dementia.2017

    • Author(s)
      Mashima K, Ito D, Kameyama M, Osada T, Tabuchi H, Nihei Y, Yoshizaki T, Noguchi E, Tanikawa M, Iizuka T, Date Y, Ogata Y, Nakahara T, Iwabuchi Y, Jinzaki M, Murakami K, Suzuki N
    • Journal Title

      Eur Neurol

      Volume: 77 Issue: 5-6 Pages: 231-237

    • DOI

      10.1159/000464322

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metabolic Tumor Volume and Total Lesion Glycolysis in PET/CT Correlate With the Pathological Findings of Colorectal Cancer and Allow Its Accurate Staging.2016

    • Author(s)
      Suzuki Y, Okabayashi K, Hasegawa H, Tsuruta M, Shigeta K, Murakami K, Kitagawa Y.
    • Journal Title

      Clin Nucl Med

      Volume: 41 Issue: 10 Pages: 761-765

    • DOI

      10.1097/rlu.0000000000001332

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hibernoma Showing High Uniform Accumulation on an 18F-Fluorodeoxyglucose Positron Emission Tomography Scan: A Case Report.2016

    • Author(s)
      Kamata Y, Kikuta K, Susa M, Nishimoto K, Sasaki A, Kameyama K, Murakami K, Nakamura M, Matsumoto M, Morioka H
    • Journal Title

      Case Rep Oncol.

      Volume: 17 Pages: 427-431

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨髄の全身評価 PETの骨髄疾患の評価2016

    • Author(s)
      岩渕 雄, 村上 康二, 伊藤 一成, 片桐 真理, 松坂 陽至, 緒方 雄史, 中原 理紀, 陣崎 雅弘
    • Journal Title

      臨床画像

      Volume: 32 Pages: 1084-1092

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【新しい小腸・大腸画像診断-現状と将来展望】 PET/CT2016

    • Author(s)
      村上 康二, 岩渕 雄, 中原 理紀, 緒方 雄史, 片桐 真理, 松坂 陽至, 伊藤 一成, 陣崎 雅弘
    • Journal Title

      胃と腸

      Volume: 51 Pages: 909-916

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【多重癌への対応-呼吸器科医の視点-】 画像診断からみた多重癌2016

    • Author(s)
      村上 康二, 中原 理紀, 緒方 雄史, 岩渕 雄, 松坂 陽至, 片桐 真理, 伊藤 一成
    • Journal Title

      日本胸部臨床

      Volume: 75 Pages: 158-166

    • Related Report
      2016 Research-status Report
  • [Journal Article] Detection of Small Skull Metastases with 18F FDG PET/CT Acquired with FlowMotion in a Patient with Lung Carcinoma2015

    • Author(s)
      Koji Murakami
    • Journal Title

      Imaging Life

      Volume: 10 Pages: 56-59

    • Related Report
      2015 Research-status Report
  • [Journal Article] Efficacy of 3D-positron emission tomography/computed tomography for upper abdomen.2014

    • Author(s)
      Murakami K, Nakahara T.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 21 Issue: 4 Pages: 246-250

    • DOI

      10.1002/jhbp.83

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The efficacy of preoperative positron emission tomography-computed tomography(PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer: clinical and pathological factors influencing it2014

    • Author(s)
      Nogami Y, Banno K, Irie H, Iida M, Kisu I, Masugi Y, Tanaka K, Tominaga E, Okuda S, Murakami K, Aoki D.
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 45 Issue: 1 Pages: 26-34

    • DOI

      10.1093/jjco/hyu161

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 頭頸部・食道腫瘍におけるPET/CTの使い方2014

    • Author(s)
      村上康二
    • Journal Title

      日本気管食道科学会会報

      Volume: 65 Pages: 199-202

    • NAID

      130004470457

    • Related Report
      2014 Research-status Report
  • [Journal Article] 悪性リンパ腫におけるがん診療ガイドラインとFDG-PET検査2014

    • Author(s)
      村上康二
    • Journal Title

      血液内科

      Volume: 68 Pages: 534-541

    • NAID

      40020085696

    • Related Report
      2014 Research-status Report
  • [Journal Article] 消化器がん検診の現状とこれから:PET/CT2014

    • Author(s)
      村上康二
    • Journal Title

      成人病と生活習慣病

      Volume: 44 Pages: 741-746

    • Related Report
      2014 Research-status Report
  • [Presentation] PET in Oncology: Recent Advancement of Technology2017

    • Author(s)
      Murakami K
    • Organizer
      第76回日本医学放射線学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Equivalent image quality between continuous bed motion and step and shoot acquisition methods in positron emission tomography2017

    • Author(s)
      Shota Takemoto, RT.1, Hideo Yamamoto, RT.1, Yuki Yamashiro, MD.1, Atsushi Nakanishi, MD.1, and Koji Murakami, MD, PhD.
    • Organizer
      Society of nuclear medicine and molecular imaging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Advancement of Technology in Oncological PET2017

    • Author(s)
      Murakami K
    • Organizer
      HIMIC 2017 at Hangzhou
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 全身ダイナミックPETにおける物理パラメータの検証2017

    • Author(s)
      山本英男1),竹元省太1),前畠彬1),坪谷宙1) 大貫弘二1)、軽部修平1),村上康二2)
    • Organizer
      日本核医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Recent advancement of technology and radiopharmaceuticals in oncology PET2017

    • Author(s)
      Murakami K
    • Organizer
      25th Annual Scientific Meeting of HKCR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PET/CT装置2機種間画像の物理的評価2017

    • Author(s)
      山本英男1),前畠彬1),竹元省太1),軽部修平1),坪谷宙1), 大貫弘二1)、村上康二2)
    • Organizer
      日本放射線技術学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 各種最新診断法がもたらす前立腺癌診療体系の変革 4.核医学検査(各種PET)2016

    • Author(s)
      村上康二
    • Organizer
      第32回前立腺シンポジウム
    • Place of Presentation
      東京カンファレンスセンター品川
    • Year and Date
      2016-12-11
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 全身ダイナミックPET/CT撮像における加算画像の臨床応用;サイノグラムベースと画像ベースの比較2016

    • Author(s)
      村上康二、岩渕 雄, 中原 理紀, 緒方 雄史, 片桐 真理, 伊藤 一成, 陣崎 雅弘
    • Organizer
      日本核医学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] New tracers and technology in PET to improve sensitivity and specificity2016

    • Author(s)
      Koji Murakami
    • Organizer
      The 15th World Congress of the International Society for Diseases of the Esophagus
    • Place of Presentation
      Singapore Expo
    • Year and Date
      2016-09-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨・軟部腫瘍診断に対するFDG-PETの有用性の検討2016

    • Author(s)
      西本 和正, 関田 哲也, 山口 さやか, 菊田 一貴, 須佐 美知郎, 堀内 圭輔, 矢部 啓夫, 村上 康二, 中村 雅也, 松本 守雄, 森岡 秀夫
    • Organizer
      日本整形外科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 大腸癌内視鏡治療後の追加腸切除における術前PET検査の有用性2016

    • Author(s)
      田島 佑樹, 鶴田 雅士, 長谷川 博俊, 岡林 剛史, 茂田 浩平, 浅田 祐介, 杉浦 清昭, 鈴木 佳透, 中太 淳平, 村上 康二, 北川 雄光
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 呼吸同期併用によるPET/CT連続寝台移動撮像法の有用性評価2015

    • Author(s)
      村上康二
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      ハイアットリージェンシー東京(東京都新宿区)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
  • [Presentation] Evaliation of image quality on PET/CT with Flow motion technology -Does it keep quantitative performance and uniformity?2015

    • Author(s)
      K.Murakami
    • Organizer
      EANM(European Association of Nuclear Medicine) congress 2015(第28回欧州核医学会)
    • Place of Presentation
      ハンブルグ(ドイツ)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 連続寝台移動型PET/CTカメラの基礎的および臨床的評価2015

    • Author(s)
      村上康二
    • Organizer
      第892回放射線診療研究会
    • Place of Presentation
      新宿住友ビル(東京都新宿区)
    • Year and Date
      2015-10-05
    • Related Report
      2015 Research-status Report
  • [Presentation] FlowMotion Technology の最新情報2015

    • Author(s)
      村上康二
    • Organizer
      PETサマーセミナー2015 in 東京ベイ
    • Place of Presentation
      東京ベイ舞浜ホテル クラブリゾート(千葉県浦安市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] PET/CT装置におけるcontinuous motion収集とstep & shoot収集との収集法の違いによる画像特性の検討2015

    • Author(s)
      大脇 由樹
    • Organizer
      第72回日本放射線技術学会総会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 連続寝台移動型PET/CTカメラの臨床性能評価に関する検討 定量性と均一性は保たれているか2014

    • Author(s)
      村上康二
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 連続寝台移動型PET/CTにおける呼吸同期法併用の有用性2014

    • Author(s)
      村上康二
    • Organizer
      PETサマーセミナー
    • Place of Presentation
      グランドパーク小樽(北海道小樽市)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] The clinical Impact of Advanced CT in PET/CT Imaging2014

    • Author(s)
      Murakami K
    • Organizer
      Siemens Molecular Imaging World Summit2014
    • Place of Presentation
      Sofitel Munich Bayerpost(ドイツ、バイエルン州)
    • Year and Date
      2014-07-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 連続寝台移動型PET/CT装置の使用経験2014

    • Author(s)
      村上康二
    • Organizer
      第81回日本核医学会関東甲信越地方会
    • Place of Presentation
      富士フイルム(株)西麻布本社講堂(東京都港区)
    • Year and Date
      2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 治療決定のための画像診断のポイント 中・下咽頭癌、喉頭癌を中心に2014

    • Author(s)
      村上康二
    • Organizer
      第38回日本頭頸部癌学会
    • Place of Presentation
      東京ファッションタウンビル(東京都江東区)
    • Year and Date
      2014-06-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Basic and Clinical Applications of PET/CT with Flow Motion Technology2014

    • Author(s)
      Murakami K
    • Organizer
      Siemens Molecular Imaging Advisory Meeting
    • Place of Presentation
      Renaissance St. Louis Grand Hotel(アメリカ合衆国ミズーリ州)
    • Year and Date
      2014-06-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 消化器癌のPET診断2014

    • Author(s)
      村上康二
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺癌の治療効果判定、再発診断2014

    • Author(s)
      村上康二
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Basic and clinical applications of PET・CT with dynamic continuous bed motion2014

    • Author(s)
      村上康二
    • Organizer
      第73回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市西区)
    • Year and Date
      2014-04-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 大腸・肛門外科の要点と盲点2014

    • Author(s)
      幕内雅敏監修 杉原健一編集
    • Total Pages
      291
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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