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Evaluation of body BPA distribution by F-BPA PET examination and study of the SUV change of F-BPA

Research Project

Project/Area Number 26461873
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

Itami Jun  国立研究開発法人国立がん研究センター, 中央病院, 科長 (40505377)

Co-Investigator(Kenkyū-buntansha) 栗原 宏明  国立研究開発法人国立がん研究センター, 中央病院, 医長 (20264674)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsFBPA PET / ホウ素中性子補足療法 / ホウ素中性子捕捉療法 / F-BPA PET / ホウ素濃度 / BPA / ホウ素中性子療法
Outline of Final Research Achievements

In boron neutron capture therapy (BNCT), treatment is performed by thermal neutron irradiation to the tumor tissue which selectively accumulates intravenously infused BPA. PET examination using FBPA is valuable to predict selective BPA accumulation in the tumor tissue. In this study, one-shot and infusion injections of FBPA shows similar uptakes in normal as well as tumor tissues 60 minutes after injection, and the uptakes predict well the BPA concentrations delivered with drip infusion. The uptakes in normal and tumor tissues seen in FBPA PET examination showed proportionality with the boron concentrations after the BPA drip infusion. Some kinds of amino acids increased uptake of FBPA in tumor tissues, which was not seen in normal tissues. The results suggest that pretreatment with such amino acids can be used as an enhancer of BNCT effect.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014

All Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 7 results,  Acknowledgement Compliant: 5 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Radiation absorbed dose estimates for 18F-BPA PET.2017

    • Author(s)
      Kono Y, Kurihara H, Kawamoto H, Yasui N, Honda N, Igaki H, Itami J.
    • Journal Title

      Acta Radiol

      Volume: Jan 1 Issue: 9 Pages: 1-1

    • DOI

      10.1177/0284185116688378

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs2017

    • Author(s)
      Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai, Kazuro Sugimura
    • Journal Title

      Radiat Oncol

      Volume: 12(1) Issue: 1 Pages: 17-17

    • DOI

      10.1186/s13014-017-0763-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo spatial correlation between (18)F-BPA and (18)F-FDG uptakes in head and neck cancer.2016

    • Author(s)
      Kobayashi K, Kurihara H, Watanabe Y, Murakami N, Inaba K, Nakamura S, Wakita A, Okamoto H, Umezawa R, Takahashi K, Igaki H, Ito Y, Yoshimoto S, Shigematsu N, Itami J.
    • Journal Title

      Appl Radiat Isot.

      Volume: 115 Pages: 138-146

    • DOI

      10.1016/j.apradiso.2016.05.026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Salvage High-dose-rate Interstitial Brachytherapy for Pelvic Recurrent Cervical Carcinoma After Hysterectomy.2016

    • Author(s)
      Murakami N, Kato T, Miyamoto Y, Nakamura S, Wakita A, Okamoto H, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 2413-2432

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma2016

    • Author(s)
      Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 192-195

    • DOI

      10.1186/s12885-016-2229-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proposed definition of the vaginal cuff and paracolpium clinical target volume in postoperative uterine cervical cancer.2016

    • Author(s)
      Murakami N, Norihisa Y, Isohashi F, Murofushi K, Ariga T, Kato T, Inaba K, Okamoto H, Ito Y, Toita T, Itami J.
    • Journal Title

      Pract Radiat Oncol.

      Volume: 6 Issue: 1 Pages: 5-11

    • DOI

      10.1016/j.prro.2015.04.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early-onset dropped head syndrome after radiotherapy for head and neck cancer: dose constraints for neck extensor muscles.2016

    • Author(s)
      Inaba K, Nakamura S, Okamoto H, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Murakami N, Ito Y, Igaki H, Uno T, Itami J.
    • Journal Title

      J Radiat Res

      Volume: 57 Issue: 2 Pages: 169-173

    • DOI

      10.1093/jrr/rrv055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer.2016

    • Author(s)
      Nakamura S, Murakami N, Inaba K, Wakita A, Kobayashi K, Takahashi K, Okamoto H, Umezawa R, Morota M, Sumi M, Igaki H, Ito Y, Itami J.
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 296-296

    • DOI

      10.1186/s12885-016-2329-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells2015

    • Author(s)
      Sato A., Itoh T., Imamichi S., Kikuhara S., Fujimori H., Hirai T., Saito S., Sakurai Y., Tanaka H., Nakamura H., Suzuki M., Murakami Y., Baiseitov D., Berikkhanova K., Zhumadilov Z., Imahori Y., Itami J., Ono K., Masunaga S., Masutani M.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 106 Pages: 113-219

    • DOI

      10.1016/j.apradiso.2015.08.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Severe gastrointestinal bleeding in patients with locally advanced head and neck squamous cell carcinoma treated by concurrent radiotherapy and Cetuximab2015

    • Author(s)
      Murakami N, Yoshimoto S, Matsumoto F, Ueno T, Ito Y, Watanabe S, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Saito Y, Itami J
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 141 Issue: 1 Pages: 177-184

    • DOI

      10.1007/s00432-014-1801-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation of (18)F-BPA and (18)F-FDG uptake in head and neck cancers.2014

    • Author(s)
      Tani H, Kurihara H, Hiroi K, Honda N, Yoshimoto M, Kono Y, Murakami R, Kumita S, Arai Y, Itami J.
    • Journal Title

      Radiother Oncol

      Volume: 113(2):193-7. Issue: 2 Pages: 193-197

    • DOI

      10.1016/j.radonc.2014.11.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer.2014

    • Author(s)
      Murakami N, Okamoto H, Kasamatsu T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Toita T, Ito Y, Itami J.
    • Journal Title

      Anticancer Research

      Volume: 34 Pages: 5091-5098

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy.2014

    • Author(s)
      Inaba K, Okamoto H, Wakita A, Nakamura S, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Murakami N, Morota M, Ito Y, Sumi M, Uno T, Itami J.
    • Journal Title

      J Radiat Res

      Volume: 55 Issue: 6 Pages: 1141-1145

    • DOI

      10.1093/jrr/rru052

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of EpCAM and prognosis in early-stage glottic cancer treated by radiotherapy2014

    • Author(s)
      Murakami N, Mori T, Yoshimoto S, Ito Y, Kobayashi K, Ken H, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Itami J.
    • Journal Title

      Laryngoscope.

      Volume: Nov;124(11): Issue: 11 Pages: 431-436

    • DOI

      10.1002/lary.24839

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] The estimation of 10B-BPA concentration in tumors by 18F-FBPA PET tests would be useful to predict effect of boron neutron capture therapy2017

    • Author(s)
      Mitsuyoshi Yoshimoto, Kenta Hiroi, Satoshi Nakamura, Hiroaki Kurihara, Natsuki Honda, Masashi Ito, Jun Itami, Hirofumi Fujii
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging Annual Meeting
    • Place of Presentation
      Denver・アメリカ
    • Year and Date
      2017-06-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Neutron Sources: NCC-CICS system2017

    • Author(s)
      Itami J
    • Organizer
      2nd Academic Coference for Taiwan Society of Neutron capture Therapy
    • Place of Presentation
      Taipei・台湾
    • Year and Date
      2017-01-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] LAT1トランスポータを介したFBPAの細胞内輸送に関する検討2016

    • Author(s)
      本田納紀、吉本光喜、栗原宏明、藤井博史、井垣浩、伊丹純
    • Organizer
      第13回日本中性子補足療法学会学術大会
    • Place of Presentation
      文京区・東京都
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] FDG PETを利用した腫瘍のF-BPAの取り込みを予測するためのスクリーニングモデルに対して腫瘍の組織型が与える影響2016

    • Author(s)
      小林和馬、井垣浩、栗原宏明、中村哲志、脇田明尚、岡本裕之、島聖、土田圭祐、柏原大朗、原田堅、梅澤玲、高橋加奈、稲葉浩二、村上直也、伊藤芳紀、伊丹純
    • Organizer
      第13回日本中性子補足療法学会学術大会
    • Place of Presentation
      文京区・東京都
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動態撮影によるF-BPA集積の時間変化2016

    • Author(s)
      井垣浩、栗原宏明、中村哲志、藤井亮、脇田明尚、柏原大朗、小林和馬、稲葉浩二、岡本裕之、今堀良夫、伊丹純
    • Organizer
      第13回日本中性子補足療法学会学術大会
    • Place of Presentation
      文京区・東京都
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 担癌マウスにおけるFBPAおよびBPAの腫瘍集積に関する比較検討2016

    • Author(s)
      吉本光喜、本田納紀、広井健太、中村哲志、栗原宏明、伊藤昌司、伊丹純、藤井博史
    • Organizer
      第13回日本中性子補足療法学会学術大会
    • Place of Presentation
      文京区・東京都
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] メラノーマ細胞株を用いた細胞と移植腫瘍へのホウ素取り込み能によるBNCT至適化条件の検討2016

    • Author(s)
      今道祥二、藤森浩彰、中村哲志、伊藤昌司、栗原宏明、今堀良夫、伊丹純、益谷美都子
    • Organizer
      第13回日本中性子補足療法学会学術大会
    • Place of Presentation
      文京区・東京都
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 当院での18F-BPA PET検査方法と標準化に向けた課題2015

    • Author(s)
      栗原宏明、井垣浩、伊丹純、藤井亮、今堀良夫
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 18F-BPA PET集積の経時的変化2015

    • Author(s)
      井垣浩、中村哲志、栗原宏明、脇田明尚、土田圭祐、柏原大朗、小林和馬、原田堅、関井修平、高橋加奈、稲葉浩二、梅澤玲、伊藤芳紀、岡本裕之、伊丹純
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 中性子測定のためのGe検出器の検出効率の算出2015

    • Author(s)
      中村哲志、脇田明尚、伊藤昌司、岡本裕之、西尾禎治、加藤融、阿部容久、伊藤芳紀、井垣浩、伊丹純
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] BNCTに対するがん細胞応答の網羅的解析ーCSF2,HMGB1の動態及び細胞外変動因子の解析2015

    • Author(s)
      今道祥二、佐藤聡、伊藤祐、菊原颯太、藤森浩彰、平井崇久、荒井康仁、今堀良夫、伊丹純、村上康文、小野公二、櫻井良憲、田中浩基、増永慎一郎、益谷美都子
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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