| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In boron neutron capture therapy (BNCT), treatment is performed by thermal neutron irradiation to the tumor tissue which selectively accumulates intravenously infused BPA. PET examination using FBPA is valuable to predict selective BPA accumulation in the tumor tissue. In this study, one-shot and infusion injections of FBPA shows similar uptakes in normal as well as tumor tissues 60 minutes after injection, and the uptakes predict well the BPA concentrations delivered with drip infusion. The uptakes in normal and tumor tissues seen in FBPA PET examination showed proportionality with the boron concentrations after the BPA drip infusion. Some kinds of amino acids increased uptake of FBPA in tumor tissues, which was not seen in normal tissues. The results suggest that pretreatment with such amino acids can be used as an enhancer of BNCT effect.
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