Evaluation of body BPA distribution by F-BPA PET examination and study of the SUV change of F-BPA
Project/Area Number |
26461873
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | National Cancer Center Japan |
Principal Investigator |
Itami Jun 国立研究開発法人国立がん研究センター, 中央病院, 科長 (40505377)
|
Co-Investigator(Kenkyū-buntansha) |
栗原 宏明 国立研究開発法人国立がん研究センター, 中央病院, 医長 (20264674)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | FBPA PET / ホウ素中性子補足療法 / ホウ素中性子捕捉療法 / F-BPA PET / ホウ素濃度 / BPA / ホウ素中性子療法 |
Outline of Final Research Achievements |
In boron neutron capture therapy (BNCT), treatment is performed by thermal neutron irradiation to the tumor tissue which selectively accumulates intravenously infused BPA. PET examination using FBPA is valuable to predict selective BPA accumulation in the tumor tissue. In this study, one-shot and infusion injections of FBPA shows similar uptakes in normal as well as tumor tissues 60 minutes after injection, and the uptakes predict well the BPA concentrations delivered with drip infusion. The uptakes in normal and tumor tissues seen in FBPA PET examination showed proportionality with the boron concentrations after the BPA drip infusion. Some kinds of amino acids increased uptake of FBPA in tumor tissues, which was not seen in normal tissues. The results suggest that pretreatment with such amino acids can be used as an enhancer of BNCT effect.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] In vivo spatial correlation between (18)F-BPA and (18)F-FDG uptakes in head and neck cancer.2016
Author(s)
Kobayashi K, Kurihara H, Watanabe Y, Murakami N, Inaba K, Nakamura S, Wakita A, Okamoto H, Umezawa R, Takahashi K, Igaki H, Ito Y, Yoshimoto S, Shigematsu N, Itami J.
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Journal Title
Appl Radiat Isot.
Volume: 115
Pages: 138-146
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Salvage High-dose-rate Interstitial Brachytherapy for Pelvic Recurrent Cervical Carcinoma After Hysterectomy.2016
Author(s)
Murakami N, Kato T, Miyamoto Y, Nakamura S, Wakita A, Okamoto H, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J.
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Journal Title
Anticancer Res.
Volume: 36
Pages: 2413-2432
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma2016
Author(s)
Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 192-195
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Proposed definition of the vaginal cuff and paracolpium clinical target volume in postoperative uterine cervical cancer.2016
Author(s)
Murakami N, Norihisa Y, Isohashi F, Murofushi K, Ariga T, Kato T, Inaba K, Okamoto H, Ito Y, Toita T, Itami J.
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Journal Title
Pract Radiat Oncol.
Volume: 6
Issue: 1
Pages: 5-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Early-onset dropped head syndrome after radiotherapy for head and neck cancer: dose constraints for neck extensor muscles.2016
Author(s)
Inaba K, Nakamura S, Okamoto H, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Murakami N, Ito Y, Igaki H, Uno T, Itami J.
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Journal Title
J Radiat Res
Volume: 57
Issue: 2
Pages: 169-173
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer.2016
Author(s)
Nakamura S, Murakami N, Inaba K, Wakita A, Kobayashi K, Takahashi K, Okamoto H, Umezawa R, Morota M, Sumi M, Igaki H, Ito Y, Itami J.
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 296-296
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells2015
Author(s)
Sato A., Itoh T., Imamichi S., Kikuhara S., Fujimori H., Hirai T., Saito S., Sakurai Y., Tanaka H., Nakamura H., Suzuki M., Murakami Y., Baiseitov D., Berikkhanova K., Zhumadilov Z., Imahori Y., Itami J., Ono K., Masunaga S., Masutani M.
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 113-219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Severe gastrointestinal bleeding in patients with locally advanced head and neck squamous cell carcinoma treated by concurrent radiotherapy and Cetuximab2015
Author(s)
Murakami N, Yoshimoto S, Matsumoto F, Ueno T, Ito Y, Watanabe S, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Saito Y, Itami J
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Journal Title
J Cancer Res Clin Oncol
Volume: 141
Issue: 1
Pages: 177-184
DOI
Related Report
Peer Reviewed
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[Journal Article] A dosimetric analysis of intensity-modulated radiation therapy with bone marrow sparing for cervical cancer.2014
Author(s)
Murakami N, Okamoto H, Kasamatsu T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Toita T, Ito Y, Itami J.
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Journal Title
Anticancer Research
Volume: 34
Pages: 5091-5098
Related Report
Peer Reviewed
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[Journal Article] Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy.2014
Author(s)
Inaba K, Okamoto H, Wakita A, Nakamura S, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Murakami N, Morota M, Ito Y, Sumi M, Uno T, Itami J.
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Journal Title
J Radiat Res
Volume: 55
Issue: 6
Pages: 1141-1145
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Expression of EpCAM and prognosis in early-stage glottic cancer treated by radiotherapy2014
Author(s)
Murakami N, Mori T, Yoshimoto S, Ito Y, Kobayashi K, Ken H, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Itami J.
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Journal Title
Laryngoscope.
Volume: Nov;124(11):
Issue: 11
Pages: 431-436
DOI
Related Report
Peer Reviewed
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