The effect of ionizing radiation on secretory phenotype of cancer-associated fibroblasts and its impact on cancer pathophysiology
| Project/Area Number |
26461875
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Yamamori Tohru 北海道大学, 獣医学研究科, 准教授 (00512675)
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| Co-Investigator(Kenkyū-buntansha) |
安井 博宣 北海道大学, アイソトープ総合センター, 准教授 (10570228)
高木 哲 北海道大学, 獣医学研究科, 准教授 (50396305)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌関連線維芽細胞 / 放射線 / サイトカイン / 活性酸素種 / 癌 / 細胞老化 / 老化関連分泌形質 / NADPHオキシダーゼ / 腫瘍間質 |
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| Outline of Final Research Achievements |
Recent evidence suggests that cancer-associated fibroblasts (CAFs), which are the most abundant cell type in cancer stroma, and CAF-derived secretory factors play important roles in various aspects of cancer pathophysiology. This study was aimed to understand how ionizing radiation influences on CAFs and their secretory phenotype. We revealed that X-irradiation to mouse embryonic fibroblasts (MEFs) increased the number of senescent cells, which are reported to have similar characteristics to CAFs. This event was accompanied by the induction of multiple cytokines. We also found that X-irradiation enhanced cellular oxidative stress level and NADPH oxidase 4 protein (NOX4) was in part responsible for it. Furthermore, our data suggested that NOX4 was not involved in the induction of secretory factors in irradiated MEFs.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Lipophilic tetraphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells2017
Author(s)
Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori T, Yamasaki T, Yamada K, Inanami O
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Journal Title
Cancer Letters
Volume: 390
Pages: 160-167
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A nucleoside anticancer drug, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, induces depth-dependent enhancement of tumor cell death in spread-out bragg peak (SOBP) of proton beam.2016
Author(s)
Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.
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Journal Title
PLoS One
Volume: 11(11)
Issue: 11
Pages: e0166848-e0166848
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.2014
Author(s)
Yasui H, Takeuchi R, Nagane M, Meike S, Nakamura Y, Yamamori T, Ikenaka Y, Kon Y, Murotani H, Oishi M, Nagasaki Y, Inanami O
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Journal Title
Cancer Letters
Volume: 347
Issue: 1
Pages: 151-158
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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