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Development of a real-time tumor-tracking proton beam therapy with molecular imaging for intractable cancers using gold nanoparticles preparation

Research Project

Project/Area Number 26461876
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

Hashimoto Takayuki  北海道大学, 医学研究科, 特任准教授 (60400678)

Co-Investigator(Kenkyū-buntansha) 伊達 広行  北海道大学, 保健科学研究院, 教授 (10197600)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Shintaro  独立行政法人日本原子力研究開発機構, 原子力基礎工学研究部門, 研究員 (60465995)
Research Collaborator Kwon Jihun  
Sutherland Kenneth L  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords金ナノ粒子 / 陽子線治療 / 難治性癌 / モンテカルロ法 / マイクロドシメトリ / 放射線増感効果 / モンテカルロシミュレーション / クラスター形成
Outline of Final Research Achievements

We conducted basic researches for developing a novel proton beam therapy as one of the multimodal therapies to improve treatment results of intractable cancers using gold nanoparticles (GNPs) as a radiosensitizer. The spatial dose distributions and dose enhancement ratio around the proton beam axis in the presence and absence of a GNPs were calculated using the Geant4 Monte Carlo simulation toolkit under various conditions. GNPs form clusters when taken up by tumor cells and shield a part of secondary electrons. Our results suggest the improvement of treatment accuracy in clinical use, because the dose enhancement is overestimated without considering energy absorption by the clustered GNPs. It is necessary to evaluate the sufficient safety including animal test before clinical application of GNPs preparation, which is highly concentrated enough to distinguish the difference of CT value as the tumor imaging agent or the fiducial marker.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Spatial distributions of dose enhancement around a gold nanoparticle at several depths of proton Bragg peak2016

    • Author(s)
      J Kwon, K Sutherland, T Hashimoto, H Shirato, and H Date
    • Journal Title

      Nucl. Instruments Methods Phys. Res. Sect. B Beam Interact. with Mater. Atoms

      Volume: 384 Pages: 113-120

    • DOI

      10.1016/j.nimb.2016.08.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dose Distribution of Electrons from Gold Nanoparticles by Proton Beam Irradiation2015

    • Author(s)
      Jihun Kwon, Kenneth Sutherland, Takayuki Hashimoto, Hiroyuki Date
    • Journal Title

      International Journal of Medical Physics, Clinical Engineering and Radiation Oncology

      Volume: 4 Issue: 01 Pages: 49-53

    • DOI

      10.4236/ijmpcero.2015.41007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Dose Enhancement by Gold Nanoparticles around the Bragg Peak of Proton beams2016

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Peng, L Xing, H Shirato, H Date
    • Organizer
      AAPM - 58th Annual Meeting
    • Place of Presentation
      Washington D.C. (USA)
    • Year and Date
      2016-08-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dose enhancement by gold nanoparticles around the Bragg peak of proton beam.2016

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Peng, L Xing, H Shirato, H Date
    • Organizer
      The American Association of Physicists in Medicine (AAPM)
    • Place of Presentation
      Washington, D.C., USA
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bragg peak近傍において金ナノ粒子が及ぼす線量増加の検討2015

    • Author(s)
      権 池勲, ケネス サザランド, 橋本 孝之, 伊達 広行
    • Organizer
      Geant4医学応用研究会
    • Place of Presentation
      富山高専射水キャンパス(富山県・射水市)
    • Year and Date
      2015-12-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Dose enhancement effect of gold nanoparticles in proton therapy at different depth before Bragg peak2015

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Date
    • Organizer
      第110回日本医学物理学会学術大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Application of gold nanoparticles as a radio sensitizer: comparison between protons and X-rays.2015

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Date.
    • Organizer
      2nd FHS International Conference
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Monte Carlo simulation of the radio sensitizing effect by gold nanoparticles: comparison between proton and X-ray irradiation.2015

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Date
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering 2015
    • Place of Presentation
      Toronto (Canada)
    • Year and Date
      2015-06-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dose distribution around gold nanoparticles in proton beam irradiation.2015

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Date
    • Organizer
      15th International Congress of Radiation Research (ICRR)
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiosensitizing effects of gold nanoparticles in proton and X-ray irradiations2015

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Date
    • Organizer
      2nd meeting of educational symposium of radiation and health (ESRAH)
    • Place of Presentation
      弘前大学(青森県・弘前市)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Monte Carlo investigation of radial dose distribution of electrons by proton beam2015

    • Author(s)
      J Kwon, K L Sutherland, T Hashimoto, H Date
    • Organizer
      第109回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-04-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Monte Carlo simulation of the electron production by proton beam irradiation to gold particles2014

    • Author(s)
      Jihun Kwon, Kenneth L. Sutherland, Takayuki Hashimoto, Hiroyuki Date
    • Organizer
      The 7th Korea-Japan Meeting on Medical Physics (KJMP2014)
    • Place of Presentation
      釜山(韓国)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Monte Carlo simulations of proton beam irradiation of gold particles2014

    • Author(s)
      Jihun Kwon, Kenneth L. Sutherland, Takayuki Hashimoto, Hiroyuki Date
    • Organizer
      1st Educational Symposium on RADIATION and HEALTH by Young Scientists (ESRAH2014)
    • Place of Presentation
      ホテルニューキャッスル(青森、弘前)
    • Year and Date
      2014-09-21 – 2014-09-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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