Cognitive impairment and MRI of long-term survivors of pediatric cancer
Project/Area Number |
26461877
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
神宮 啓一 東北大学, 医学(系)研究科(研究院), その他 (00451592)
力石 健 東北大学, 大学病院, 助教 (40400379)
高橋 昭喜 東北大学, 医学系研究科, 名誉教授 (80148874)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | MRI / 認知機能障害 / 脳腫瘍 / 小児がん / 放射線治療 / 小児癌 / 白血病 / 晩期認知機能 |
Outline of Final Research Achievements |
We sought to determine effects of radiation field size and dose on the extent of developing cavernous malformations in long-term survivors of pediatric cancer.The study involved 34 patients with a history of intracranial germ cell tumors treated with either whole-brain or reduced-field irradiation and undergoing MRI with a mean follow-up of 18.5 years. A total of 235 cavernous malformation lesions were observed in 32 of 34 patients. The mean number of lesions was 2.3 times as high in the whole-brain group as in the reduced-field group. The number of lesions in high-dose fields was significantly larger than in low-dose or untreated fields. Radiation field size and dose were positively associated with the number of cavernous malformations developed. Cavernous malformations can be used as a surrogate marker for microvascular injury following intracranial irradiation in long-term cancer survivors.
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Report
(5 results)
Research Products
(64 results)
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[Journal Article] Paradoxical association of symptomatic local vasogenic edema with global cerebral hypoperfusion after direct revascularization surgery for adult moyamoya disease2018
Author(s)
Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T
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Journal Title
Tashiro R, FUJIMURA M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T
Volume: -
Issue: 8
Pages: e172-e176
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome.2017
Author(s)
Kano M, Muratsubaki T, Van Oudenhove L, Morishita J, Yoshizawa M, Kohno K, Yagihashi M, Tanaka Y, Mugikura S, Dupont P, Ly HG, Takase K, Kanazawa M, Fukudo S.
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Journal Title
Sci Rep
Volume: 29
Issue: 1
Pages: 12425-12425
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.2016
Author(s)
Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Ezura M, Kobayashi M, Tano O, Mugikura S, Iwata R, Ishiki A, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M.
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Journal Title
Neurology.
Volume: 29
Pages: 2309-2316
Related Report
Peer Reviewed
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[Journal Article] Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development.2016
Author(s)
Takai Y, Misu T, Nishiyama S, Ono H, Kuroda H, Nakashima I, Saito R, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Aoki M, Fujihara K.
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Journal Title
Neurology.
Volume: 8
Pages: 2000-2005
Related Report
Peer Reviewed
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[Journal Article] Gender differences in ventromedial prefrontal cortex activity associated with valuation of faces.2016
Author(s)
Ito A, Fujii T, Abe N, Kawasaki I, Hayashi A, Ueno A, Yoshida K, Sakai S, Mugikura S, Takahashi S, Mori E.
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Journal Title
Neuroscience.
Volume: 328
Pages: 194-200
DOI
Related Report
Peer Reviewed
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[Journal Article] Lesion length of optic neuritis impacts visual prognosi in neuromyelitis optica2016
Author(s)
Akaishi T, Ichiro Nakashima, Takeshita T, Mugikura S, Sato DK, Takahashi T, Nishiyama S, Kurosawa K, Misu T, Nakazawa T, Aoki M, Fujihara K
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Journal Title
J Neuroimmunol
Volume: 293
Pages: 28-33
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] 腫瘍性疾患2016
Author(s)
麦倉 俊司
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Journal Title
臨床放射線61巻臨時増刊号 Multi-Organ Disease ─臓器からアプローチする全身疾患─
Volume: 61
Pages: 1319-1322
Related Report
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[Journal Article] 内分泌疾患2016
Author(s)
麦倉 俊司
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Journal Title
臨床放射線61巻臨時増刊号 Multi-Organ Disease ─臓器からアプローチする全身疾患─
Volume: 61
Pages: 1345-1348
Related Report
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[Journal Article] Intraventricular hemorrhage on initial computed tomography as marker of diffuse axonal injury after traumatic brain injury.2015
Author(s)
Mata-Mbemba D, Mugikura S, Nakagawa A, Murata T, Kato Y, Tatewaki Y, Li L, Takase K, Ishii K, Kushimoto S, Tominaga T, Takahashi S.
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Journal Title
J Neurotrauma.
Volume: 1;32(5):
Issue: 5
Pages: 359-65
DOI
Related Report
Peer Reviewed
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[Presentation] Age-related change of optic radiation: quantitative volumetric analysis with tissue enhanced SWIp.2015
Author(s)
Tatewaki Y, Taki Y, Thyreau B, Matsudaira I, Omodaka K, Nakazawa T, Nagasaka T,Murata T, Kato Y, Mugikura S, Mata-Mbemba D, Li L, Sekiguchi A, Takase K.
Organizer
Organization for Human Brain Mapping (OHBM)
Place of Presentation
Honolulu, Hawaii, USA,
Year and Date
2015-06-14
Related Report
Int'l Joint Research
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[Presentation] てんかんの画像診断2015
Author(s)
麦倉 俊司
Organizer
第38回日本てんかん外科学会 合同教育セミナー
Place of Presentation
東京(都市センターホテル)
Year and Date
2015-01-16
Related Report
Invited
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