The effect of HPV status on radiation sensitivity of photon and carbon-ion radiotherapy in head and neck squamous cell carcinoma
Project/Area Number |
26461878
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Gunma University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | HPV / 頭頸部扁平上皮癌 / p16 / HPV status |
Outline of Final Research Achievements |
HPV related tumors affect the radiation sensitivity in head and neck squamous cell carcinoma. In this study, we performed in vitro experiments and translational research to investigate the different radiation sensitivity between carbon-ion radiotherapy and photon therapy according to HPV status. At first, we used HPV positive and negative tumors in head and neck squamous cell lines. Clonogenic survival assay was performed to determine radiation sensitivity of carbon-ion radiotherapy and photon therapy. Furthermore, we evaluated HPV status and compared the clinical results in the patients with head and neck squamous cell carcinoma treated with chemoradiotherapy to compare the radiosensitivity.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] A Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer-A pilot study.2017
Author(s)
Shirai K, Kawashima M, Saitoh JI, Abe T, Fukata K, Shigeta Y, Irie D, Shiba S, Okano N, Ohno T, Nakano T.
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Journal Title
PLoS One.
Volume: 12
Issue: 4
Pages: e0175589-e0175589
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Maximum standardized uptake value on FDG-PET predicts survival in stage I non-small-cell lung cancer after carbon ion radiotherapy.2017
Author(s)
Shirai K, Abe T, Saitoh J, Mizukami T, Irie D, Takakusagi Y, Shiba S, Okano N, Ebara T, Ohno T, Nakano T.
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Journal Title
Oncology letters.
Volume: 13
Issue: 6
Pages: 4420-4426
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer.2016
Author(s)
Shirai K, Saitoh J, Musha A, Abe T, Kobayashi D, Takakusagi Y, Takayasu Y, Shino M, Toyoda M, Takahashi K, Chikamatsu K, Ohno T, Nakano T.
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Journal Title
Anticancer Res.
Volume: 36
Pages: 6571-8
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Brainstem necrosis of head and neck tumors treated with Carbon-ion radiotherapy.2017
Author(s)
Katsuyuki Shirai, Kyohei Fukata, Akiko Adachi, Jun-ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Yuka Shigeta, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano.
Organizer
The 7th International Society of Radiation Neurobiology Conference.
Place of Presentation
湯沢
Year and Date
2017-02-09
Related Report
Int'l Joint Research
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