| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
HPV related tumors affect the radiation sensitivity in head and neck squamous cell carcinoma. In this study, we performed in vitro experiments and translational research to investigate the different radiation sensitivity between carbon-ion radiotherapy and photon therapy according to HPV status.
At first, we used HPV positive and negative tumors in head and neck squamous cell lines. Clonogenic survival assay was performed to determine radiation sensitivity of carbon-ion radiotherapy and photon therapy. Furthermore, we evaluated HPV status and compared the clinical results in the patients with head and neck squamous cell carcinoma treated with chemoradiotherapy to compare the radiosensitivity.
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