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Study on image-guided brachytherapy for gynecological tumors

Research Project

Project/Area Number 26461879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

Ohno Tatsuya  群馬大学, 重粒子線医学推進機構, 教授 (10344061)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords放射線治療 / 小線源治療 / 婦人科腫瘍 / 画像誘導小線源治療 / 子宮頸癌
Outline of Final Research Achievements

We investigate the long-term clinical outcomes of cervical cancer patients treated with in-room computed tomography-based brachytherapy using Japanese standard radiotherapy schedule. The 5-year LC rate according to tumor size were 96%, 91%, and 94% for tumors <4 cm, tumors 4-6 cm, and tumors >6 cm, respectively. The proportions of patients with a high risk clinical target volume (HR-CTV) D90 of >60 Gy (EQD2), D2cc of the rectum of <75 Gy (EQD2), and D2cc of the bladder of <90 Gy (EQD2) were 90%, 99%, and 93%, respectively. There were no significant differences in the HR-CTV D90 among patients with different sized tumors. Then, along with the developing recommendations for contouring HR-CTV for cervical cancer, prospective evaluation in a multicenter setting has been on-going to confirm these findings.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Invited: 5 results)

  • [Journal Article] In-room computed tomography-based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study.2016

    • Author(s)
      Ohno T, Noda SE, Okonogi N, Murata K, Shibuya K, Kiyohara H, Tamaki T, Ando K, Oike T, Ohkubo Y, Wakatsuki M, Saitoh JI, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 57 Issue: 4 Pages: 543-551

    • DOI

      10.1093/jrr/rrw121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recommendations for high-risk clinical target volume definition with computed tomography for three-dimensional image-guided brachytherapy in cervical cancer patients2016

    • Author(s)
      Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Ii, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-ei Noda, Tomoko Kazumoto, Yoko Harima
    • Journal Title

      J Radiat Res

      Volume: 56 Issue: 3 Pages: 1-10

    • DOI

      10.1093/jrr/rrw109

    • NAID

      120006959731

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dose-volume histogram analysis of composite EQD2 dose distributions using the central shielding technique in cervical cancer radiotherapy.2016

    • Author(s)
      Tamaki T, Noda SE, Ohno T, Kumazaki Y, Kato S, Nakano T.
    • Journal Title

      Brachytherapy

      Volume: 59 Issue: 5 Pages: 598-606

    • DOI

      10.1016/j.brachy.2016.06.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A questionnaire-based survey on 3D image-guided brachytherapy for cervical cancer in Japan: advances and obstacles.2015

    • Author(s)
      Ohno T, Toita T, Tsujino K, Uchida N, Hatano K, Nishimura T, Ishikura S.
    • Journal Title

      J Radiat Res.

      Volume: 56 Issue: 6 Pages: 897-903

    • DOI

      10.1093/jrr/rrv047

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Can combined intracavitary/interstitial approach be an alternative to interstitial brachytherapy with the Martinez Universal Perineal Interstitial Template (MUPIT) in computed tomography-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumors?2014

    • Author(s)
      Oike T, Ohno T, Noda SE, Kiyohara H, Ando K, Shibuya K, Tamaki T, Takakusagi T,Sato H,Nakano T
    • Journal Title

      Radiat Oncol.

      Volume: 16 Issue: 1 Pages: 222-222

    • DOI

      10.1186/s13014-014-0222-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dose-volume histogram parameters of high-dose-rate brachytherapy for Stage I-II cervical cancer (>4cm) arising from a small-sized uterus treated with a point A dose-reduced plan.2014

    • Author(s)
      Nakagawa A, Ohno T, Noda SE, Kubo N, Kuwako K, Saitoh J, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 55 Issue: 4 Pages: 788-93

    • DOI

      10.1093/jrr/rru006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 子宮頸癌に対する同室内CTを用いた3次元画像誘導小線源治療の長期成績2016

    • Author(s)
      大野達也、野田真永、小此木範之、村田和俊、吉本由哉、大西真弘、小林大二郎、斎藤淳一、中野隆史
    • Organizer
      第54回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] In-room CT based brachytherapy for cervical cancer2016

    • Author(s)
      Ohno T.
    • Organizer
      FNCA FY2012 Workshop on Radiation Oncology
    • Place of Presentation
      スラバヤ、インドネシア
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 子宮頸癌に対する3次元画像誘導小線源治療の多施設共同研究2016

    • Author(s)
      大野達也
    • Organizer
      小線源治療部会 第18回学術大会
    • Place of Presentation
      大阪
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 婦人科悪性腫瘍に対する重粒子線治療2015

    • Author(s)
      大野達也
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 3D image-based brachytherapy for cervical cancer: Experience of Gunma University2015

    • Author(s)
      Ohno T.
    • Organizer
      Seminar on Radiation Oncology in Shirilaj Hospital
    • Place of Presentation
      Bangkok
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 子宮頸癌のHybrid IGBT:3D-IGBTにおける医師側からみた注意点・問題点2014

    • Author(s)
      大野達也、野田真永、田巻倫明、安藤謙、村田和俊、中野隆史
    • Organizer
      小線源治療部会第16回学術大会
    • Place of Presentation
      幕張
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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