Study on image-guided brachytherapy for gynecological tumors
| Project/Area Number |
26461879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
Ohno Tatsuya 群馬大学, 重粒子線医学推進機構, 教授 (10344061)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線治療 / 小線源治療 / 婦人科腫瘍 / 画像誘導小線源治療 / 子宮頸癌 |
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| Outline of Final Research Achievements |
We investigate the long-term clinical outcomes of cervical cancer patients treated with in-room computed tomography-based brachytherapy using Japanese standard radiotherapy schedule. The 5-year LC rate according to tumor size were 96%, 91%, and 94% for tumors <4 cm, tumors 4-6 cm, and tumors >6 cm, respectively. The proportions of patients with a high risk clinical target volume (HR-CTV) D90 of >60 Gy (EQD2), D2cc of the rectum of <75 Gy (EQD2), and D2cc of the bladder of <90 Gy (EQD2) were 90%, 99%, and 93%, respectively. There were no significant differences in the HR-CTV D90 among patients with different sized tumors. Then, along with the developing recommendations for contouring HR-CTV for cervical cancer, prospective evaluation in a multicenter setting has been on-going to confirm these findings.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] In-room computed tomography-based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study.2016
Author(s)
Ohno T, Noda SE, Okonogi N, Murata K, Shibuya K, Kiyohara H, Tamaki T, Ando K, Oike T, Ohkubo Y, Wakatsuki M, Saitoh JI, Nakano T.
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Journal Title
J Radiat Res.
Volume: 57
Issue: 4
Pages: 543-551
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Recommendations for high-risk clinical target volume definition with computed tomography for three-dimensional image-guided brachytherapy in cervical cancer patients2016
Author(s)
Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Ii, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-ei Noda, Tomoko Kazumoto, Yoko Harima
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Journal Title
J Radiat Res
Volume: 56
Issue: 3
Pages: 1-10
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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