| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In order to develop effective cancer therapies targeting DNA damage response, it is important to clarify the molecular mechanisms which induce abnormalities in DNA damage response in each cancer. In this study, we investigated the mitotic roles of the synaptonemal complex protein SYCE2, which is not expressed in normal mitotic cells but aberrantly expressed in cancer. We found that SYCE2 activates the ATM-mediated DNA damage response and induces radioresistance and that treatment with the ATM inhibitor abrogates radioresistance observed in SYCE2-expressing cells.
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