Order-made radiation therapy using functional imaging for lung and liver cancer

• Project/Area Number: 26461889
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: Kimura Tomoki 広島大学, 病院(医), 講師 (90379876)
• Co-Investigator(Kenkyū-buntansha): 永田 靖 広島大学, 医歯薬保健学研究院(医), 教授 (10228033) ; 村上 祐司 広島大学, 医歯薬保健学研究院(医), 講師 (10403528)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺癌 / 肝臓癌 / 肺機能画像 / 肝機能画像 / 放射線治療 / 放射線肺臓炎 / オーダーメイド治療

Outline of Final Research Achievements

１）Functional lung imaging:The purpose of this study was to prospectively investigate clinical correlations between dosimetric parameters associated with radiation pneumonitis (RP) and functional lung imaging.Regarding the functional lung ratio and RP incidence, more than grade 3 RP was observed significantly more frequently in patients with a lower functional lung ratio.
2)Functional liver imaging: The aim of this study is to evaluate the ability of EOB-MRI-guided stereotactic body radiation therapy (SBRT) planning by using IMRT techniques in sparing the functional liver tissues during SBRT for HCC.Twenty HCC patients were enrolled, and compared the liver dose between an anatomical plan optimization based on the total liver and a functional plan based on the functional liver.Compared with anatomical plans,functional plans significantly reduced liver dose including functional liver. EOB-MRI-guided SBRT planning using the IMRT may preserve functional liver tissues in HCC patients.

Research Products

• [Int'l Joint Research] University of California Davis(米国)
• [Int'l Joint Research] University of California Davis (米国)
• [Journal Article] Functional Image-guided Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients (2017)
  • Author(s): Uranchimeg Tsegmed, Tomoki Kimura, Takeo Nakashima, Yuko Nakamura, Toru Higaki, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Kazuo Awai, Yasushi Nagata.
  • Journal Title: Medical Dosimetry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Functional Image-Guided Radiotherapy Planning in Volumetric Modulated Arc Therapy for Patients with Malignant Pleural Mesothelioma (2017)
  • Author(s): Yoshiko Doi, Tomoki Kimura, Takeo Nakashima, Keiichi Onishi, Yuki takeuchi, Ikuno Nishibuchi, Tomoyuki Okabe, Yuji Murakami, Yasushi Nagata
  • Journal Title: Advances in Radiation Oncology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Clinical experience of volumetric modulated arc therapy for malignant pleural mesothelioma after extrapleural pneumonectomy (2015)
  • Author(s): Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Nobuki Imano, Tsuyoshi Katsuta, Shigeo Takahashi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata.
  • Journal Title: Journal of Radiation research Volume: 56 Pages: 315-324
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The time course of dynamic computed tomographic appearance of radiation injury to the cirrhotic liver following stereotactic body radiation therapy for hepatocellular carcinoma. (2015)
  • Author(s): Tomoki Kimura, Shigeo Takahashi, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi, Masahiro Kenjo, Yuji Murakami, Yohji Honda, Hiroshi Aikata, Kazuaki Chayama, and Yasushi Nagata.
  • Journal Title: PLoS ONE Volume: 10
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combined ventilation and perfusion imaging correlate with the dosimetric parameters of radiation pneumonitis in radiotherapy planning for lung cancer. (2015)
  • Author(s): Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Nobuki Imano, Hideo Kawabata, Ikuno Nishibuchi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata.
  • Journal Title: Int.J. Radiat. Oncol. Biol. Phys Volume: 93 Pages: 778-787
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The role of 3D-conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma. (2015)
  • Author(s): Hatsue Fujino, Tomoki Kimura, Hiroshi Aikata, et al.
  • Journal Title: Hepatology research Volume: 45 Pages: 607-617
  • Peer Reviewed
• [Journal Article] Long-term results of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer (T1bN0M0) (2015)
  • Author(s): Yuji Murakami, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi1, Tomoyuki Okabe,
  • Journal Title: Int.J. Clin. Oncol Volume: 20 Pages: 897-904
  • Peer Reviewed
• [Journal Article] Results of sequential chemoradiotherapy for intracranial germinoma (2015)
  • Author(s): Masahiro Kenjo, Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Yuji Murakami, Tomoki Kimura, Yoshiko Doi, Tomoyuki Okabe, Kazuhiko Sugiyama, Yasushi Nagata.
  • Journal Title: Jpn J Radiol Volume: 33 Pages: 336-343
  • NAID: 50009519123
  • Peer Reviewed
• [Journal Article] Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma. (2015)
  • Author(s): Yuko Nakamura, Tomoki Kimura, Toru Higaki, Yukiko Honda, Daisuke Komoto, Takuji Yamagami, Makoto Iida, Yasushi Nagata, Yohji Honda, Hiroshi Aikata, Kazuaki Chayama, Kazuo Awai.
  • Journal Title: Jpn J Radiol Volume: 33 Pages: 627-635
  • NAID: 50009607232
  • Peer Reviewed
• [Journal Article] Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies (2015)
  • Author(s): Tomoki Kimura, Hiroshi Aikata, Shigeo Takahashi, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi, Masahiro Kenjo, Yuji Murakami, Yoji Honda, Hideaki Kakizawa, Kazuo Awai, Kazuaki Chayama, Yasushi Nagata.
  • Journal Title: Hepatology Research Volume: 45 Pages: 378-386
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Case Reports of Portal Vein Thrombosis and Bile Duct Stenosis after Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma. (2014)
  • Author(s): Shigeo Takahashi, Tomoki Kimura, Masahiro Kenjo, Ikuno Nishibuchi, Ippei Takahashi, Yuki Takeuchi, Yoshiko Doi, Yuko Kaneyasu, Yuji Murakami, Yoji Honda, Hiroshi Aikata, Kazuaki Chayama, and Yasushi Nagata
  • Journal Title: Hepatology Research Volume: 44
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Time-Adjusted Internal Target Volume: A Novel Approach Focusing on Heterogeneity of Tumor Motion Based on Four-Dimensional Computed Tomography Imaging for Radiotherapy Planning of Lung Cancer. (2014)
  • Author(s): Ikuno Nishibuchi, Tomoki Kimura, Takeo Nakashima, Yusuke Ochi, Ippei Takahashi, Yoshiko Doi, Masahiro Kenjo, Yuko Kaneyasu, Yuji Murakami, Koichi Wadasaki, Yasushi Nagata.
  • Journal Title: Int.J. Radiat. Oncol. Biol. Phys Volume: 89
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pilot Study of Stereotactic Body Radiation Therapy Combined with Transcatheter Arterial Chemoembolization for Small Hepatocellular Carcinoma. (2014)
  • Author(s): Yohji Honda, Tomoki Kimura, Hiroshi Aikata, Takashi Nakahara, Noriaki Naeshiro,
  • Journal Title: Hepato-gastroenterology Volume: 61 Pages: 31-36
  • Peer Reviewed
• [Presentation] 肺機能画像は放射線肺臓炎の線量分布パラメータに相関する (2016)
  • Author(s): 木村智樹、中島健雄、斉藤明登、竹内有樹、高橋一平、西淵いくの、村上祐司、西尾禎治、永田 靖
  • Organizer: 第57回日本肺癌学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-12-18
• [Presentation] Combined ventilation and perfusion imaging correlates with the dosimetric parameters of radiation pneumonitis in radiation therapy planning for lung cancer (2016)
  • Author(s): Tomoki Kimura, Takeo Nakashima, Akito Saito, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Teiji Nishio, Yasushi Nagata
  • Organizer: The 58th annual ASTRO Meeting
  • Place of Presentation: Boston、USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Functional lung imaging correlates with DVH parameters of radiation pneumonitis (2016)
  • Author(s): Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Akito Saito, Yasushi Nagata
  • Organizer: The 4th Taiwan-Japan Radiation Oncology Symposium
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-06-04
  • Int'l Joint Research / Invited
• [Presentation] A phase I study of stereotactic body radiation therapy for centrally located stage IA non-small cell lung cancer: Japan Radiation Oncology Study Group (JROSG10-1) (2015)
  • Author(s): Tomoki Kimura, Yasushi Nagata, Hideyuki Harada, Shinya Hayash, Yukinori Matsuo, Nami Ueki, Tsuyoshi Takanaka, Masaki Kokubo, Kenji Takayama, Hiroshi Onishi, Koichi Hirakawa, Yoshiyuki Shioyama, Takeshi Ehara.
  • Organizer: 第57回米国放射線腫瘍学会
  • Place of Presentation: サンアントニオ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] A Quantitative Index for Phase Selection in Planning of Respiratory Gating Radiation Therapy for Lung Cancer. (2015)
  • Author(s): Nobuki Imano, Tomoki Kimura, Ikuno Nishibuchi, Takeo Nakashima, Katsumaro Kubo, Hiromi Sakaguchi, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata.
  • Organizer: 第57回米国放射線腫瘍学会
  • Place of Presentation: サンアントニオ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Computed Tomographic Appearance of Radiation Injuries in Lung After Two Prescribed Dose of 48Gy With Stereotactic Body Radiation Therapy. (2015)
  • Author(s): Katsumaro Kubo, Tomoki Kimura, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa Yuji Murakami, Yasushi Nagata.
  • Organizer: 第57回米国放射線腫瘍学会
  • Place of Presentation: サンアントニオ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Interstitial Brachytherapy for Early-Stage Tongue Cancer: Analysis of the Long-term Treatment Results for Survival and Complications. (2015)
  • Author(s): Yuki Takeuchi, Yuji Murakami, Katsumaro Kubo, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata, Minoru Fujita, Masaru Konishi.
  • Organizer: 第57回米国放射線腫瘍学会
  • Place of Presentation: サンアントニオ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Incidence and Clinical Features of Metachronous Esophageal Cancer After Definitive Radiation Therapy for Esophageal Cancer. (2015)
  • Author(s): Yuji Murakami, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata.
  • Organizer: 第57回米国放射線腫瘍学会
  • Place of Presentation: サンアントニオ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Gd-EOB-DTPA Enhanced MRI Guided Stereotactic Body Radiation Therapy Planning for Patients With Hepatocellular Carcinoma. (2015)
  • Author(s): Uranchimeg Tsegmed, Tomoki Kimura, Takeo Nakashima, Yuko Nakamura, Toru Higaki, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Kazuo Awai, Yasushi Nagata.
  • Organizer: 第57回米国放射線腫瘍学会
  • Place of Presentation: サンアントニオ（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Clinical outcomes of stereotactic body radiotherapy for small lung tumors clinically diagnoses as primary lung cancer. (2015)
  • Author(s): Hiromi Sakaguchi, Tomoki Kimura, Katsumaro Kubo, Nobuki Imano, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yuji Murakami, Yasushi Nagata.
  • Organizer: 15th International Congress of Radiation Research (ICRR)
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Involved-field radiation therapy for patients with stage III non-small-cell lung cancer. (2015)
  • Author(s): Katsumaro Kubo, Tomoki Kimura, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yuji Murakami, Yasushi Nagata.
  • Organizer: 15th International Congress of Radiation Research (ICRR)
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Preliminary results of postoperative radioactive iodine ablation therapy for differentiated thyroid cancer. (2015)
  • Author(s): Masahiro Kenjo, Hideo Kawabata, Katsumaro Kubo, Hiromi Sakaguchi, Nobuki Imano, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Yuji Murakami, Tomoki Kimura, Yasushi Nagata.
  • Organizer: 15th International Congress of Radiation Research (ICRR)
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Treatment outcomes of preoperative chemoradiotherapy for Japanese patients with locally advanced rectal cancer. (2015)
  • Author(s): Hideo Kawabata, Yuji Murakami, Hiromi Sakaguchi, Katsumaro Kubo, Nobuki Imano, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yuko Kaneyasu, Yasushi Nagata.
  • Organizer: 15th International Congress of Radiation Research (ICRR)
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Preliminary outcomes of induction chemotherapy + VMAT with concurrent chemotherapy for stage IVA/IVB oro- and hypopharyngeal cancer. (2015)
  • Author(s): Yuji Murakami, Tomoki Kimura, Katsumaro Kubo, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yasushi Nagata.
  • Organizer: 15th International Congress of Radiation Research (ICRR)
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] A Prospective Study of Functional Image Guided Radiation Therapy Planning in Lung Cancer Patients. (2014)
  • Author(s): Tomoki Kimura, Takeshi Nakashima, Yoshiko Doi, Nobuki Imano, Tsuyoshi Katsuta, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Mukrakami, Yasushi Nagata
  • Organizer: 第56回米国放射線腫瘍学会
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Results of Neoadjuvant Chemoradiation Therapy Followed by Surgery for Locally Advanced Esophageal Squamous Cell Carcinoma. (2014)
  • Author(s): Yuji Mukrakami, Nobuki Imano, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yuko Kaneyasu, Tomoki Kimura, Jun Hihara, Yasushi Nagata
  • Organizer: 第56回米国放射線腫瘍学会
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Long-Term Results of Postoperative 3-Dimensional High-Dose-Rate Brachytherapy for Soft-Tissue Sarcomas (2014)
  • Author(s): Masahiro Kenjo, Kubo T, Shimose S, Fujimori J, Nakashima Y, Yoshiko Doi, Tomoyuki Okabe, Yuji Mukrakami, Tomoki Kimura, Yuko Kaneyasu, Yasushi Nagata.
  • Organizer: 第56回米国放射線腫瘍学会
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Four-Dimensional Assessment of the Internal Motion of Esophagus in Early-Stage Esophageal Cancer Patients Using Metal Markers. (2014)
  • Author(s): Yoshiko Doi, Yuji Mukrakami, Tsuyoshi Katsuta, Nobuki Imano, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yuko Kaneyasu, Yasushi Nagata.
  • Organizer: 第56回米国放射線腫瘍学会
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Functional Image-Guided Stereotactic Body Radiation Therapy Planning Using the Intensity Modulated Radiation Therapy Technique for Patients With Hepatocellular Carcinoma. (2014)
  • Author(s): Tsegmed U, Tomoki Kimura, Takeshi Nakashima, Yuko Nakamura, Toru Higaki, Tsuyoshi Katsuta, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Yuko Kaneyasu, Shuichi Ozawa, Yuji Mukrakami, Kazuo Awai, Yasushi Nagata.
  • Organizer: 第56回米国放射線腫瘍学会
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Current status of stereotactic body radiotherapy for hepatocellular carcinoma in Japan (2014)
  • Author(s): Tomoki Kimura
  • Organizer: 第2回台日高精度放射線治療研究会
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2014-07-19 – 2014-07-20
  • Invited
• [Book] Stereotactic Body Radiation Therapy, Principles and Practices. (2015)
  • Author(s): Yasushi Nagata, Tomoki Kimura, et al.
  • Total Pages: 250
  • Publisher: Springer