Standardization in treatment planning for intensity-modulated radiation therapy for various clinical applications
| Project/Area Number |
26461892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
Shibata Toru 香川大学, 医学部附属病院, 教授 (40293857)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 強度変調放射線治療 / 放射線治療計画 / 頭頸部癌 / 標準化 |
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| Outline of Final Research Achievements |
IMRT is a high-precision technique that can produce optimized dose distributions between the targets and adjacent normal structures. Further developments of standardized technology could play an important role for promoting the application of IMRT for various cancers in Japan. In this research project to help standardization of IMRT treatment planning, we establish a novel 3-arc method for head and neck VMRT to improve planning quality, and a multi-step adaptive scheme for nasopharyngeal VMAT to treatment-induced shrinkage of primary and nodal lesions. We also investigate the impact of pelvic rotational setup error on lymph nodal dose in whole pelvic IMRT using fiducial markers for prostate cancers, to increase the accuracy of dose delivery to lymph node regions. A prospective trial for malignant gliomas using IMRT has been also performed. In this period, we have treated total 181 patients with IMRT, including 78 head-and-neck, 92 prostate, 3 cervical cancers ,and 8 malignant gliomas.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Accelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx2015
Author(s)
Takahashi, S., Miyashita, T., Hoshikawa, H., Haba, R., Togami, T. Shibata, T.
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Journal Title
Head Neck
Volume: 37
Issue: 5
Pages: 63-65
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) with Chemotherapy for Locoregionally Advanced Nasopharyngeal Cancer (NPC) (JCOG1015): Acute Toxicity and Treatment Compliance2016
Author(s)
Y. Nishimura, T. Kodaira, Y. Ito, K. Tsuchiya, Y. Murakami, J.I. Saitoh, T. Akimoto, K. Nakata, M. Yoshimura, T. Teshima, T. Toshiyasu, Y. Ota, K. Ishikawa, H. Shimizu, T. Minemura, S. Ishikura, T. Shibata, K. Nakamura, T. Shibata, M. Hiraoka
Organizer
American Society for Radiation Oncology 58th Annual Meeting
Place of Presentation
Boston, USA
Year and Date
2016-09-25
Related Report
Int'l Joint Research
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[Presentation] Radiotherapy with or without concurrent chemotherapy for T1-3 glottic carcinoma: A retrospective analysis2014
Author(s)
Takahashi, S., Togami, T., Mori, T., Kishino, T., Hoshikawa, H. Mori, N., Shibata, T.
Organizer
第73回日本医学放射線学会総会
Place of Presentation
横浜市
Year and Date
2014-04-10 – 2014-04-13
Related Report
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