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Standardization in treatment planning for intensity-modulated radiation therapy for various clinical applications

Research Project

Project/Area Number 26461892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKagawa University

Principal Investigator

Shibata Toru  香川大学, 医学部附属病院, 教授 (40293857)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords強度変調放射線治療 / 放射線治療計画 / 頭頸部癌 / 標準化
Outline of Final Research Achievements

IMRT is a high-precision technique that can produce optimized dose distributions between the targets and adjacent normal structures. Further developments of standardized technology could play an important role for promoting the application of IMRT for various cancers in Japan. In this research project to help standardization of IMRT treatment planning, we establish a novel 3-arc method for head and neck VMRT to improve planning quality, and a multi-step adaptive scheme for nasopharyngeal VMAT to treatment-induced shrinkage of primary and nodal lesions. We also investigate the impact of pelvic rotational setup error on lymph nodal dose in whole pelvic IMRT using fiducial markers for prostate cancers, to increase the accuracy of dose delivery to lymph node regions. A prospective trial for malignant gliomas using IMRT has been also performed. In this period, we have treated total 181 patients with IMRT, including 78 head-and-neck, 92 prostate, 3 cervical cancers ,and 8 malignant gliomas.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (37 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (29 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (2 results)

  • [Journal Article] Clinical outcomes of IMRT planned with or without PET/CT simulation for patients with pharyngeal cancers2017

    • Author(s)
      Matsuura T, Nishimura Y, Nakamatsu K, Kanamori S, Ishikawa K, Tachibana I, Hosono M, Shibata T.
    • Journal Title

      Int J Clin Oncol

      Volume: 22 Issue: 1 Pages: 52-58

    • DOI

      10.1007/s10147-016-1034-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of Pelvic Rotational Setup Error on Lymph Nodal Dose in Whole Pelvic IMRT Using Fiducial Markers2016

    • Author(s)
      片山博貴、大久保正臣、續木将人、笹川泰弘、高橋重雄、柴田 徹
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 72 Issue: 11 Pages: 1152-1160

    • DOI

      10.6009/jjrt.2016_JSRT_72.11.1152

    • NAID

      130005284253

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between dose-volume parameters and pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for lung cancer.2016

    • Author(s)
      Shigeo Takahashi; Tetsuhiko Go; Yoshitaka Kasai; Hiroyasu Yokomise; Toru Shibata
    • Journal Title

      Strahlenther Onkol.

      Volume: 192 Issue: 9 Pages: 658-67

    • DOI

      10.1007/s00066-016-1021-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 頭頸部腫瘍に対するIMRTと画像情報の利用2016

    • Author(s)
      柴田 徹
    • Journal Title

      臨床放射線

      Volume: 61 Pages: 1733-1741

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Accelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx2015

    • Author(s)
      Takahashi, S., Miyashita, T., Hoshikawa, H., Haba, R., Togami, T. Shibata, T.
    • Journal Title

      Head Neck

      Volume: 37 Issue: 5 Pages: 63-65

    • DOI

      10.1002/hed.23888

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 限局性前立腺癌に対する放射線療法2015

    • Author(s)
      柴田 徹
    • Journal Title

      日本泌尿器科学会 卒後教育テキスト

      Volume: 20 Pages: 84-92

    • Related Report
      2015 Research-status Report
  • [Presentation] 頭頸部腫瘍に対する強度変調放射線治療ーその威力と魅力2017

    • Author(s)
      柴田 徹
    • Organizer
      国立病院機構福山医療センターオープンカンファレンス
    • Place of Presentation
      福山市
    • Year and Date
      2017-02-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] IMRT for head and neck cancers: target delineation and treatment planning2017

    • Author(s)
      Toru Shibata
    • Organizer
      IAEA-RCA-CC International Training Course on Advanced Radiation Therapy
    • Place of Presentation
      広島市
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 悪性神経膠腫に対する強度変調放射線治療2016

    • Author(s)
      髙橋重雄; 木下敏史; 柴田 徹
    • Organizer
      第42回香川放射線治療談話会
    • Place of Presentation
      高松市
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 上咽頭癌に対するMulti-step Adaptive IMRT2016

    • Author(s)
      髙橋重雄; 木下敏史; 森 照茂; 星川広史; 柴田 徹
    • Organizer
      平成28年度 香川県医学会
    • Place of Presentation
      高松市
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 特別講演:頭頸部腫瘍に対するIMRTの現状と将来展望2016

    • Author(s)
      柴田 徹
    • Organizer
      第16回近畿放射線医学フォーラム
    • Place of Presentation
      大阪市
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Respiratory motion of lymph node stations for pancreatic cancer: Analyses using contrast-enhanced four-dimensional computed tomography2016

    • Author(s)
      Shigeo Takahashi; Toshifumi Kinoshita; Toru Shibata
    • Organizer
      American Society for Radiation Oncology 58th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) with Chemotherapy for Locoregionally Advanced Nasopharyngeal Cancer (NPC) (JCOG1015): Acute Toxicity and Treatment Compliance2016

    • Author(s)
      Y. Nishimura, T. Kodaira, Y. Ito, K. Tsuchiya, Y. Murakami, J.I. Saitoh, T. Akimoto, K. Nakata, M. Yoshimura, T. Teshima, T. Toshiyasu, Y. Ota, K. Ishikawa, H. Shimizu, T. Minemura, S. Ishikura, T. Shibata, K. Nakamura, T. Shibata, M. Hiraoka
    • Organizer
      American Society for Radiation Oncology 58th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 教育講演:頭頸部腫瘍に対する強度変調放射線治療:解法の探求2016

    • Author(s)
      柴田 徹
    • Organizer
      第68回 中国・四国放射線治療懇話会
    • Place of Presentation
      広島市
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Differences in gross tumor volumes for pancreatic cancer: A comparison of ungated positron emission tomography and contrast-enhanced 4-dimensional computed tomography2016

    • Author(s)
      Shigeo Takahashi; Toshifumi Kinoshita; Toru Shibata
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] シンポジウム4「高精度放射線治療のための最適な画像診断に向けて」2. 頭頸部腫瘍に対するIMRTと画像診断2016

    • Author(s)
      柴田 徹
    • Organizer
      第75回 日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] シンポジウム4「高精度放射線治療のための最適な画像診断に向けて」2. 頭頸部腫瘍に対するIMRTと画像診断2016

    • Author(s)
      柴田 徹
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Differences in gross tumor volumes for pancreatic cancer: A comparison of ungated positron emission tomography and contrast-enhanced 4-dimensional computed tomography2016

    • Author(s)
      Shigeo Takahashi; Toshifumi Kinoshita; Toru Shibata
    • Organizer
      第75回 日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of the respiratory motion of lymph node regions in patients with pancreatic cancer using contrast-enhanced 4-dimensional computed tomography2015

    • Author(s)
      Shigeo Takahashi; Toshifumi Kinoshita; Toru Shibata
    • Organizer
      日本放射線腫瘍学会 第28回学術大会
    • Place of Presentation
      前橋市
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 中枢神経・頭頸部2015

    • Author(s)
      柴田 徹
    • Organizer
      第3回JCR放射線科レジデントセミナー
    • Place of Presentation
      東京都
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 限局性前立腺癌に対する放射線療法2015

    • Author(s)
      柴田 徹
    • Organizer
      第65回 日本泌尿器科学会 中部総会
    • Place of Presentation
      岐阜県
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Clinical experience of definitive radiotherapy for synchronous head and neck and esophageal cancer2015

    • Author(s)
      Shigeo Takahashi; Toshifumi Kinoshita; Toru Shibata
    • Organizer
      The joint meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japanese Society for Head and Neck Cancer
    • Place of Presentation
      Kobe
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Patterns of failure out of gross tumor volume for high-grade glioma: analyses using deformable image registration approach2015

    • Author(s)
      Shigeo Takahashi; Toshifumi Kinoshita; Toru Shibata
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Recent Advances in Radiotherapy for Prostate Cancer2015

    • Author(s)
      Toru Shibata
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 頭頸部癌に対する強度変調放射線治療の新展開2015

    • Author(s)
      柴田 徹
    • Organizer
      日本耳鼻咽喉科学会第104回香川県地方部会総会
    • Place of Presentation
      高松市
    • Year and Date
      2015-04-04
    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Invited
  • [Presentation] 膵癌リンパ節領域の呼吸性移動に関する検討2015

    • Author(s)
      髙橋重雄、木下敏史、柴田 徹
    • Organizer
      第39回京都放射線腫瘍研究会
    • Place of Presentation
      京都市
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 前立腺SIB-IMRT:6軸位置補正が線量分布に及ぼす影響2015

    • Author(s)
      片山博貴、大久保正臣、續木将人、山崎達也、森裕一郎、加藤耕二、高橋重雄、柴田 徹
    • Organizer
      第39回京都放射線腫瘍研究会
    • Place of Presentation
      京都市
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Delineating targets in head and neck cancer2015

    • Author(s)
      Toru Shibata
    • Organizer
      IAEA/RCA regional training course: An update on Advanced Technologies in Radiotherapy
    • Place of Presentation
      Hiroshima
    • Year and Date
      2015-01-19 – 2015-01-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 頭頸部癌と食道癌の同時重複癌に対する根治照射の経験2014

    • Author(s)
      髙橋重雄、木下敏史、戸上太郎、柴田 徹
    • Organizer
      第123回日本医学放射線学会中国・四国地方会
    • Place of Presentation
      愛媛県東温市
    • Year and Date
      2014-12-20 – 2014-12-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Deformable image registration を用いた高悪性度グリオーマの GTV 外増悪形式の検討2014

    • Author(s)
      髙橋重雄、木下敏史、戸上太郎、柴田 徹
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-12-11 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺癌に対する術前化学放射線療法における肺線量と肺有害事象の関連についての後方視的検討2014

    • Author(s)
      髙橋重雄、呉 哲彦、横見瀬裕保、柴田 徹
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 前立腺癌治療の進歩~放射線療法~2014

    • Author(s)
      柴田 徹
    • Organizer
      DECLICON(デクリコン)大川地区
    • Place of Presentation
      東かがわ市
    • Year and Date
      2014-10-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Stereotactic body radiation therapy for solitary pulmonary nodules detected after resection of primary lung cancer2014

    • Author(s)
      Takahashi, S., Kimura, T., Togami, T., Shibata, T.
    • Organizer
      15th Asian Oceanian Congress of Radiology
    • Place of Presentation
      Kobe
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] The relationship between mean lung dose and pulmonary complications after neoadjuvant chemoradiation therapy followed by surgery for lung cancer2014

    • Author(s)
      Takahashi, S., Go, T., Togami, T. Yokomise, H., Shibata, T.
    • Organizer
      The 56th Annual Meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Radiotherapy with or without concurrent chemotherapy for T1-3 glottic carcinoma: A retrospective analysis2014

    • Author(s)
      Takahashi, S., Togami, T., Mori, T., Kishino, T., Hoshikawa, H. Mori, N., Shibata, T.
    • Organizer
      第73回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-04-10 – 2014-04-13
    • Related Report
      2014 Research-status Report
  • [Book] Q&Aでわかる香川大学医学部附属病院の最新治療2016

    • Author(s)
      香川大学医学部附属病院
    • Total Pages
      159
    • Publisher
      バリューメディカル
    • Related Report
      2016 Annual Research Report
  • [Book] Chapter 4. Treatment Planning of IMRT for Head and Neck Malignancies., p.59-84, in Intensity-Modulated Radiation Therapy Clinical Evidence and Techniques (Editors: Nishimura, Y. Komaki, R.)2015

    • Author(s)
      Toru Shibata(分担執筆)
    • Total Pages
      465
    • Publisher
      Springer Japan
    • Related Report
      2015 Research-status Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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