Development of Computer-aided Radiotherapy Planning System Using Searching Engine of Previous Similar Cases

• Project/Area Number: 26461894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Yoshitake Tadamasa 九州大学, 医学研究院, 講師 (40452750)
• Co-Investigator(Kenkyū-buntansha): 佐々木 智成 九州大学, 医学研究院, 准教授 (10380437) ; 中村 和正 九州大学, 大学病院, 准教授 (20284507) ; 有村 秀孝 九州大学, 医学研究院, 教授 (20287353) ; 寺嶋 広太郎 九州大学, 大学病院, 助教 (40627676) ; 本田 浩 九州大学, 医学研究院, 教授 (90145433) ; 大賀 才路 九州大学, 大学病院, 助教 (90380427) ; 松本 圭司 九州大学, 大学病院, 医員 (40467907) ; 山口 俊博 九州大学, 先端医療イノベーションセンター, 助教 (00419607) ; 浅井 佳央里 九州大学, 大学病院, 医員 (40635471)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 放射線治療 / コンピュータ支援 / 体幹部定位放射線治療 / 治療計画 / 肺癌

Outline of Final Research Achievements

The computer-aided radiotherapy planning system (CARPS) has been developed to search similar cases among the previously registered 81 cases and to apply the previous beam directions to new cases, semi-automatically.
Four planners performed stereotactic body radiation therapy (SBRT) planning of 8 lung cancer cases with and without CARPS. The elapsed time of these procedure are measured as the planning time.We evaluated the planning time, dosimetric parameters, and subjective evaluation of planners. The planning times with CARPS were shorter than those without CARPS in all planners. There was significant difference between two groups. The dosimetric parameters were equivalent in two groups. In conclusion, the SBRT planning with CARPS using previous similar cases can reduce the planning time with the equivalent dosimetric parameters to those without CARPS.

Research Products

• [Journal Article] Impact of Interstitial Changes on Radiation Pneumonitis After Stereotactic Body Radiation Therapy for Lung Cancer. (2015)
  • Author(s): Yoshitake T, Shioyama Y, Asai K, Nakamura K, Sasaki T, Ohga S, Kamitani T, Yamaguchi T, Ohshima K, Matsumoto K, Kawanami S, Honda H.
  • Journal Title: Anticancer Research Volume: 35 Pages: 4909-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical characteristics and outcome of pneumothorax after stereotactic body radiotherapy for lung tumors. (2015)
  • Author(s): Asai K, Nakamura K, Shioyama Y, Sasaki T, Matsuo Y, Ohga S, Yoshitake T, Terashima K, Shinoto M, Matsumoto K, Hirata H, Honda H.
  • Journal Title: Int J Clin Oncol Volume: epub Issue: 6 Pages: 1117-21
  • DOI: 10.1007/s10147-015-0833-4
  • Peer Reviewed / Open Access
• [Journal Article] Treatment Planning Comparison for Carbon Ion Radiotherapy, Proton Therapy and Intensity-modulated Radiotherapy for Spinal Sarcoma. (2015)
  • Author(s): Matsumoto K, Nakamura K, Shioyama Y, Sasaki T, Ohga S, Yamaguchi T, Yoshitake T, Asai K, Kakiuchi G, Honda H.
  • Journal Title: Anticancer Research Volume: 35 Pages: 4083-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Treatment Outcome of Radiotherapy for Localized Primary Ocular Adnexal MALT Lymphoma--Prognostic Effect of the AJCC Tumor-Node-Metastasis Clinical Staging System. (2015)
  • Author(s): Ohga S, Nakamura K, Shioyama Y, Sasaki T, Yamaguchi T, Yoshitake T, Terashima K, Asai K, Matsumoto K, Honda H.
  • Journal Title: Anticancer Research Volume: 35 Pages: 3591-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stereotactic body radiation therapy for primary lung cancers clinically diagnosed without pathological confirmation: a single-institution experience. (2015)
  • Author(s): Yoshitake T1, Nakamura K, Shioyama Y, Sasaki T, Ohga S, Shinoto M, Terashima K, Asai K, Matsumoto K, Matsuo Y, Baba S, Honda H.
  • Journal Title: International Journal of Clinical Oncology Volume: 20 Issue: 1 Pages: 53-58
  • DOI: 10.1007/s10147-014-0698-y
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] A preliminary result of computer-aided radiotherapy planning system using previous similar cases for stereotactic body radiotherapy (2017)
  • Author(s): 吉武 忠正
  • Organizer: 第76回日本医学放射線科学会総会
  • Place of Presentation: 横浜
• [Presentation] High Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Poor Survival in Patients With Glioblastoma Treated With Radiation Therapy and Temozolomide (2016)
  • Author(s): 吉武 忠正
  • Organizer: ASTRO annual meeting 2016
  • Place of Presentation: Boston
• [Presentation] ulmonary Interstitial Changes Is a Predictive Factor for Radiation Pneumonitis After Stereotactic Body Radiation Therapy for Lung Cancer Patients (2015)
  • Author(s): T. Yoshitake, K. Nakamura, T. Sasaki, S. Ohga, T. Yamaguchi, K. Asai, K. Ohshima, K. Matsumoto, T. Kamitani, S. Kawanami, Y. Shioyama, H. Honda
  • Organizer: 57th Annual meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Antonio
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Stereotactic Body Radiation Therapy for Histologically Confirmed Stage I Non-Small Cell Lung Cancer: Treatment Results and Patterns of Recurrence (2015)
  • Author(s): K. Asai, K. Nakamura, Y. Shioyama, T. Sasaki, S. Ohga, T. Yamaguchi, T. Yoshitake, S. Baba, S. Kawanami, K. Ohshima, K. Matsumoto, M. Inamori, K. Hiramine, H. Honda
  • Organizer: 57th Annual meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Antonio
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Comparison of Treatment Planning for Carbon Ion Radiation Therapy, Proton Therapy and Intensity Modulated Radiation Therapy for Spinal Tumors Encircling the Spinal Cord (2015)
  • Author(s): K. Matsumoto, K. Nakamura, Y. Shioyama, T. Sasaki, S. Ohga, T. Yamaguchi, T. Yoshitake, K. Asai, K. Ohshima, M. Inamori, K. Hiramine, H. Honda
  • Organizer: 57th Annual meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Antonio
  • Year and Date: 2015-10-18
  • Int'l Joint Research