| Project/Area Number |
26461896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三藤 久 北里大学, 看護学部, 准教授 (40260856)
蒋 世旭 北里大学, 医学部, 准教授 (70276153)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUDA Noriyuki 北里大学, 医学部, 教授 (70145465)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 肺癌 / 放射線治療 / バイオマーカー / 効果予測 / 個別化医療 / 分子標的 / 非小細胞肺癌 / 化学放射線療法 / EGFR遺伝子変異 / EGFRチロシンキナーゼ阻害薬 / 放射線感受性 / 肺腺癌 / Vimentin / 予後因子 / 放射線反応性 |
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| Outline of Final Research Achievements |
In adenocarcinoma of the lung, vimentin expression is prevalent and markedly up-regulated in micropapllary component (MPC), which might reflect the biological essence of poorer differentiation or dedifferentiation of MPC, and this might have a role in the acquisition and increase of invasiveness and consequent more malignant nature of MPC. In the 64 patients with stage III non-small cell lung cancer (NSCLC), the progression-free survival (PFS) was significantly shorter, and the overall survival (OS) was longer (6.3 vs. 9.5 months, p < .001, PFS, 37.1 vs. 21.1 months, p = 0.26, OS). Distant metastasis happened more frequently in the mutant EGFR than in the wild-type EGFR. In 39 patients received concurrent chemoradiotherapy with a humanized IgG1 monoclonal anti-EGFR antibody (nimotuzumab), the PFS was significantly better for patients with Sq than for those with Non-Sq. The low in field relapse rates may be attributed to the radio-sensitizing effect of anti-EGFR antibody.
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