| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Glioblastoma is highly lethal disease. Radiotherapy plays important role but tumor recurrence is occurred in most of cases. We focused low-dose hyper-radiosensitivity phenomena as a new treatment strategy. Cell survival, cell cycle and rate of apoptosis were measured. Survival rate decreased in association with increasing dose on single low dose irradiation suggestive of hyper-radiosensitivity in some cell lines. On the other hand, the observed cell cycle change of G1/G2 ratio was less than 5%.
The survival rate lowered when an interval became longer by low dose repeat irradiation (LDRR). The moderate change of the G1/G2 ratio was observed in the examination 30 minutes after irradiation only at 30 minutes interval. A rise of the apoptotic component was observed at 30 minutes interval. The LDRR at 30 minutes interval seems to be a promising approach, although, confirmation by other technique and elucidation of the further mechanism is warranted.
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