Development of new strategy for glioblastoma focused on low-dose hyper-radiosensitivity
| Project/Area Number |
26461897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Keio University |
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Principal Investigator |
FUKADA Junichi 慶應義塾大学, 医学部(信濃町), 講師 (50338159)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 膠芽腫 / 放射線照射 / 低線量照射 / グリオーマ / 放射線低線量照射 / 細胞周期 / アポトーシス / 放射線生物学 |
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| Outline of Final Research Achievements |
Glioblastoma is highly lethal disease. Radiotherapy plays important role but tumor recurrence is occurred in most of cases. We focused low-dose hyper-radiosensitivity phenomena as a new treatment strategy. Cell survival, cell cycle and rate of apoptosis were measured. Survival rate decreased in association with increasing dose on single low dose irradiation suggestive of hyper-radiosensitivity in some cell lines. On the other hand, the observed cell cycle change of G1/G2 ratio was less than 5%.
The survival rate lowered when an interval became longer by low dose repeat irradiation (LDRR). The moderate change of the G1/G2 ratio was observed in the examination 30 minutes after irradiation only at 30 minutes interval. A rise of the apoptotic component was observed at 30 minutes interval. The LDRR at 30 minutes interval seems to be a promising approach, although, confirmation by other technique and elucidation of the further mechanism is warranted.
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Report
(4 results)
Research Products
(11 results)
