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Proof of new generation, high-precision dose computational algorithm

Research Project

Project/Area Number 26461898
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionTokai University

Principal Investigator

KUNIEDA Etsuo  東海大学, 医学部, 教授 (70170008)

Co-Investigator(Kenkyū-buntansha) 株木 重人  東海大学, 医学部, 講師 (00402777)
尾川 浩一  法政大学, 理工学部, 教授 (00158817)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsVMAT / 放射線治療 / アルゴリズム / 最適化 / vat
Outline of Final Research Achievements

We proposed a new method for treatment planning of the rotational Volumetric Arc Therapy (rotational VMAT) and persuaded improving treatment efficiency and stunted the safe and minimal patient's load therapy by shorting of the treatment time. In other words, with the aim of improving treatment effects, we have been developed a new innovative irradiation method, which exceed simple VMAT or Tomotherapy irradiation. The new irradiation method could maximize the merit of the machine feature of a CT type machine with maltileaf collimator capability. We performed monte-calro simulations based on Geant4. Actual measurements were identically simulated, The inter-leave leakages and doses were correctly estimated. The DICOM capability also performed. TIMRT optimization, algorithm for MLC control, and the shortest route problem were analyzed and framework development were performed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and radiofrequency ablation.2016

    • Author(s)
      Takeda A, Sanuki N, Tsurugai Y, Iwabuchi S, Matsunaga K, Ebinuma H, Imajo K, Aoki Y, Saito H, Kunieda E.
    • Journal Title

      Cancer

      Volume: 122 Issue: 13 Pages: 2041-9

    • DOI

      10.1002/cncr.30008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosimetric evaluation of the feasibility of stereotactic body radiotherapy for primary lung cancer with lobe-specific selective elective nodal irradiation.2016

    • Author(s)
      Komatsu T, Kunieda E, Kitahara T, Akiba T, Nagao R, Fukuzawa T.
    • Journal Title

      J Radiat Res.

      Volume: 57 Issue: 1 Pages: 75-83

    • DOI

      10.1093/jrr/rrv067

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] 医療用コンプトンガンマ線カメラのデザインシミュレーション2016

    • Author(s)
      高野 奨悟, 藤井 柊輔 櫛田 淳子 西嶋 恭司 山下 諄 株木 重人 國枝 悦夫
    • Journal Title

      東海大学理学部紀要

      Volume: 51 Pages: 19-25

    • NAID

      120005818972

    • Related Report
      2015 Research-status Report
  • [Journal Article] Prospective Trial of Stereotactic Body Radiation Therapy for Both Operable and Inoperable T1N0M0 Non-Small Cell Lung Cancer: Japan Clinical Oncology Group Study JCOG0403.2015

    • Author(s)
      Nagata Y, Hiraoka M, Shibata T, Onishi H, Kokubo M, Karasawa K, Shioyama Y, Onimaru R, Kozuka T, Kunieda E, Saito T, Nakagawa K, Hareyama M, Takai Y, Hayakawa K, Mitsuhashi N, Ishikura S.
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 93 Issue: 5 Pages: 989-96

    • DOI

      10.1016/j.ijrobp.2015.07.2278

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 薬物による放射線有害事象の修飾2015

    • Author(s)
      北原 規, 國枝 悦夫
    • Journal Title

      乳癌の臨床

      Volume: 30 Pages: 521-527

    • Related Report
      2015 Research-status Report
  • [Journal Article] Stereotactic radiosurgery with or without whole-brain radiotherapy for brain metastases: Secondary analysis of the JROSG 99-1 randomized clinical trial2015

    • Author(s)
      Aoyama, Hidefumi, Tago, Masao Shirato, Hiroki Kato, Norio Iuchi, Toshihiko Nakagawa, Keiichi Toyoda, Tatsuya Hatano, Kazuo Kenjyo, Masahiro Oya, Natsuo Hirota, Saeko Shioura, Hiroki Inomata, Taisuke Hayakawa, Kazushige Akazawa, Kohei Mehta, Minesh P Hirota, Etsuo Kunieda
    • Journal Title

      JAMA Oncol.

      Volume: 1 Issue: 4 Pages: 457

    • DOI

      10.1001/jamaoncol.2015.1145

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of liver toxicities on prognosis after stereotactic body radiation therapy for hepatocellular carcinoma2015

    • Author(s)
      Sanuki, Naoko, Takeda, Atsuya Oku, Yohei Eriguchi, Takahisa Nishimura, Shuichi Aoki, Yosuke Etsuo Kunieda
    • Journal Title

      Hepatol Res.

      Volume: 45 Issue: 5 Pages: 540-7

    • DOI

      10.1111/hepr.12383

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 前立腺癌IMRTの線量増加における成績の検討2016

    • Author(s)
      福澤 毅  秋庭 健志 小松 哲也 長尾 隆太 小林 俊昭 広木 智之 北原 規 國枝 悦夫
    • Organizer
      第29回高精度放射線外部照射部会学術大会
    • Place of Presentation
      一橋大学 一橋講堂 千代田区,東京
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Safety Evaluation of Irradiation for Post Mastectomy Patients with Tissue Expander2015

    • Author(s)
      Toshiaki Kobayashi  Tadashi Kitahara Tsuyoshi Fukuzawa Takeshi Akiba Tetsuya Komatsu Ryuta Nagao Etsuo Kunieda
    • Organizer
      日本放射線腫瘍学会第28回学術大会
    • Place of Presentation
      ベイシア文化ホール 前橋市,群馬県
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Characteristics of complete remission cases in advanced non-small cell lung cancer2015

    • Author(s)
      Takuya Aoki Kazuki Harada Jun Tanaka Masako Sato Yukihiro Horio Hiroto Takiguchi Hiromi Tomomatsu Katsuyoshi Tomomatsu Takahisa Takihara Kyoko Niimi Naoki Hayama Tsuyoshi Oguma Takeshi Akiba Tetsuya Komatsu Tomoki Nakagawa Ryota Masuda Hiroshi Kajiwara Etsuo Kunieda
    • Organizer
      16th World Conference on Lung Cancer
    • Place of Presentation
      Colorado Convention Center,Denver, Colorado, USA
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] イメージングプレートを用いた放射線照射野の幾何学QA法の開発2014

    • Author(s)
      広木智之 臼井桂介 菊池朋子 株木重人 前平祥太 神谷陽 戸高秀晴 国枝悦夫
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] モンテカルロシミュレーションを用いた金ナノ粒子の放射線増感効果の基礎的検討2014

    • Author(s)
      川俣郁馬 株木重人 小松哲也 国枝悦夫
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-12-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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