Theoretical study on relative biological effectiveness for BNCT and radionuclide therapy

• Project/Area Number: 26461900
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Japan Atomic Energy Agency
• Principal Investigator: Sato Tatsuhiko 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力基礎工学研究センター, 研究主幹 (30354707)
• Co-Investigator(Kenkyū-buntansha): 熊田 博明 筑波大学, 医学医療系, 准教授 (30354913)
• Research Collaborator: HAMADA Nobuyuki 一般財団法人電力中央研究所, 放射線安全研究センター, 主任研究員 ; HASEGAWA Sumitaka 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所, チームリーダー
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: BNCT / RI内用療法 / 細胞生存率 / 生物学的効果比 / マイクロドジメトリ / 放射線治療計画 / PHITS / バイスタンダー効果

Outline of Final Research Achievements

Aim of this study is to determine the relative biological effectiveness of Boron Neutron Capture Therapy (BNCT) and radionuclide therapy based on the heterogeneity of absorbed doses in microscopic scales. For that purpose, we improved the double stochastic microdosimetric kinetic (DSMK) model to be capable of considering bystander effect, radioresistance caused by overexpression of anti-apoptotic protein Bcl-2, and intra and inter-cellular heterogeneity in drug concentration. The accuracy of the improved model was well verified by cell surviving fractions obtained from an animal experiment simulating BNCT. The improved model will be incorporated into the Particle and Heavy Ion Transport code System PHITS, and used in the treatment planning of BNCT and radionuclide therapy.

Research Products

• [Journal Article] Model Assembly for Estimating Cell Surviving Fraction for Both Targeted and Nontargeted Effects Based on Microdosimetric Probability Densities (2014)
  • Author(s): T. Sato and N. Hamada
  • Journal Title: PLOS ONE Volume: 9 Issue: 11 Pages: e114056-e114056
  • DOI: 10.1371/journal.pone.0114056
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] RI内用療法及びBNCTの生物学的効果比に関する理論的研究 (2016)
  • Author(s): 佐藤達彦，浜田信行，熊田博明，長谷川純崇，坂下哲哉
  • Organizer: 放射線影響学会第59回大会
  • Place of Presentation: 広島JMSアステールプラザ（広島県広島市）
  • Year and Date: 2016-10-26
• [Presentation] Recent improvements of the PHITS code (2016)
  • Author(s): T. Sato, K. Niita, Y. Iwamoto, S. Hashimoto, T. Ogawa, T. Furuta, S. Abe, T. Kai, N. Matsuda, K. Okumura, T. Kai, H. Iwase, L. Sihver
  • Organizer: 13th International Conference on Radiation Shielding (ICRS-13)
  • Place of Presentation: パリ（フランス）
  • Year and Date: 2016-10-03
  • Int'l Joint Research
• [Presentation] Characterization of microbeam and broadbeam fields in the same framework using microdosimetric probability density (2015)
  • Author(s): T. Sato, N. Hamada, T. Sakashita
  • Organizer: 12th International Workshop on Microbeam Probes of Cellular Radiation Response (IWM 2015)
  • Place of Presentation: 若狭湾エネルギー研究センター 福井県敦賀市
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Role of Bcl-2 overexpression and nontargeted effect in the estimate of RBE-weighted doses for heavy ion therapy and BNCT (2015)
  • Author(s): T. Sato, N. Hamada, H. Kumada
  • Organizer: 15th International Congress of Radiation Research (ICRR 2015)
  • Place of Presentation: 京都国際会館 京都府京都市
  • Year and Date: 2015-05-24
  • Int'l Joint Research
• [Presentation] マイクロドジメトリに基づく標的・非標的効果を同時に考慮可能な細胞生存率評価モデル (2014)
  • Author(s): 佐藤達彦，浜田信行
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-01 – 2014-10-03