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Time Course Assessment of Changing Tissue RedOx Status after X-ray or Carbon-beam Irradiation using RedOx Imaging Technique

Research Project

Project/Area Number 26461901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Matsumoto Ken-ichiro  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線障害治療研究部, チームリーダー(定常) (10297046)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsレドックスイメージング / 組織レドックス状態 / 酸化ストレス / 放射線 / 重粒子線 / ニトロキシルラジカル / 活性酸素 / フリーラジカル / レドックス感受性造影剤 / X線 / 炭素線 / 磁気共鳴 / ラジカル還元
Outline of Final Research Achievements

The in vivo T1-weighted contrasting abilities and signal decay behaviors of several nitroxyl contrast agents in mouse brain were compared. The amphiphilic 3-methoxy-carbonyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (MCP) and 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) had good initial uniform distribution in the brain and showed typical 2-phase signal decay profiles. Nitroxyl contrast agents equipped with a suitable lipophilic substitution group could be BBB-permeable functional contrast agents.
Daily variations of redox behavior in mouse brain after irradiation of X-ray or carbon-ion beams were tried to estimate based on the in vivo reduction rate of amphiphilic nitroxyl contrast agents, MCP and TEMPOL. Irradiation of ionized radiation to head could cause alternation of redox status in the brain 2 days after X-ray irradiation or 1 day after carbon-beam irradiation. Superoxide leakage from damaged mitochondria can be concerned due to increased decay rate of TEMPOL.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance Redox Imaging2015

    • Author(s)
      松本 謙一郎,山崎 俊栄,中村 美月,上野 恵美,中西 郁夫,柴田 さやか,関田 愛子,佐賀 恒夫,鎌田 正,山田 健一,青木 伊知男
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: 76 Issue: 3 Pages: 935-945

    • DOI

      10.1002/mrm.25918

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Trial of brain redox imaging and estimation of radiation-induced redox change in mouse brain2017

    • Author(s)
      Matsumoto K, Nakamura M, Ueno M, Nakanishi I, Kamada T, Yamada K, Aoki I
    • Organizer
      The 7th International Society of Radiation Neurobiology Conference
    • Place of Presentation
      越後湯沢温泉ホテル双葉、新潟県南魚沼郡湯沢町
    • Year and Date
      2017-02-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニトロキシル造影剤によるMRレドックスイメージング2015

    • Author(s)
      松本謙一郎
    • Organizer
      第54回電子スピンサイエンス学会年会(SEST2015)
    • Place of Presentation
      新潟
    • Year and Date
      2015-11-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 放射線照射後の組織におけるレドックス状態変化の解析2014

    • Author(s)
      4.中村美月, 柴田さやか, 尾澤芳和, 上野恵美, 松本謙一郎, 山田健一, 鎌田正, 青木伊知男
    • Organizer
      第29回日本酸化ストレス学会関東支部会
    • Place of Presentation
      筑波大学東京キャンパス
    • Year and Date
      2014-12-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Time course analysis of radiation induced alteration of tissue redox status using MR redox imaging2014

    • Author(s)
      3.Nakamura M, Shibata S, Ozawa Y, Ueno M, Matsumoto K, Yamada K, Kamada T, Aoki I
    • Organizer
      APES-IES-SEST 2014 (Joint Conference of 9th Asia-Pacific EPR/ESR Society Symposium, 1st International EPR (ESR) Society Symposium, and 53th SEST Annual Meeting)
    • Place of Presentation
      奈良
    • Year and Date
      2014-11-12 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 放射線照射後に生じる組織レドックス状態の経時変化―MR レドックスイメージングによる画像解析2014

    • Author(s)
      2.中村美月, 柴田さやか, 尾澤芳和, 上野恵美, 松本謙一郎, 山田健一, 鎌田正, 青木伊知男
    • Organizer
      日本放射線影響学会 第57回大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 放射線で誘発される組織レドックス状態の画像解析2014

    • Author(s)
      1.中村美月, 柴田さやか, 尾澤芳和, 上野恵美, 松本謙一郎, 山田健一, 鎌田正, 青木伊知男
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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