| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Islet transplantation is a curative treatment option for Type-1 diabetes. The outcome would improve with amelioration of isolated islet function. From the previous experiments, addition of rare sugar D-allose to islet culture medium improved insulin secretion ability and the diabetes cure rate after transplantation. It has been suggested that an antioxidative effect of D-allose may be a mechanism for improving islet function. In addition, in the present experiment, pancreatic islets were transplanted into diabetic model mice, and D-allose was injected to the recipient mice immediately, 24 and 48 hours after transplantation. As a result, the diabetes cure rate was significantly increased compared with the control. We are now investigating the mechanism of this ameliorating effect of D-allose immunohistochemically.
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