A study for improvement of pancreatic islet transplantation outcome by using rare sugar D-allose.
| Project/Area Number |
26461914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
徳田 雅明 香川大学, 医学部, 教授 (10163974)
浅野 栄介 香川大学, 医学部附属病院, 病院助教 (90467837)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 希少糖 / 膵島移植 |
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| Outline of Final Research Achievements |
Islet transplantation is a curative treatment option for Type-1 diabetes. The outcome would improve with amelioration of isolated islet function. From the previous experiments, addition of rare sugar D-allose to islet culture medium improved insulin secretion ability and the diabetes cure rate after transplantation. It has been suggested that an antioxidative effect of D-allose may be a mechanism for improving islet function. In addition, in the present experiment, pancreatic islets were transplanted into diabetic model mice, and D-allose was injected to the recipient mice immediately, 24 and 48 hours after transplantation. As a result, the diabetes cure rate was significantly increased compared with the control. We are now investigating the mechanism of this ameliorating effect of D-allose immunohistochemically.
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Report
(4 results)
Research Products
(4 results)
