| Project/Area Number |
26461922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Yoshimura Norio 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191643)
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| Co-Investigator(Kenkyū-buntansha) |
越野 勝博 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50727295)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 腎移植 / ＩｇＡ腎症再発 / 扁桃摘出 / ＩｇＡ腎症 / 移植腎 / 再発 / 移植外科学 |
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| Outline of Final Research Achievements |
Since 2014, we have performed tonsillectomy for patients with recurrent immunoglobulin A nephropathy (IgAN) after kidney transplantation. One patient with primary IgAN showed biopsy-proven recurrent IgAN after living donor kidney transplantation. He had persistent proteinuria or hematuria after kidney transplantation. After tonsillectomy, he showed rapid progressione, and developed severe renal injury after tonsillectomy, or other problems such as refractory hypertension. This case suggested antibody mediated rejection was developed after tonsillectomy. Thererfore, two careful points were suggested (1) Only patients who showed recurrent IgA nephropathy alone should be selected, (2) we carefully take care of the course after tonsillectomy , (3) steroid should be used after tonsillectomy to prevent immunological active reaction.
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