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Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissue

Research Project

Project/Area Number 26461925
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionJichi Medical University

Principal Investigator

SAKUMA YASUNARU  自治医科大学, 医学部, 准教授 (10296105)

Co-Investigator(Kenkyū-buntansha) 三木 厚  自治医科大学, 医学部, 講師 (20570378)
安田 是和  自治医科大学, 医学部, 客員教授 (40158001)
上本 伸二  京都大学, 医学研究科, 教授 (40252449)
笠原 尚哉  自治医科大学, 医学部, 助教 (50382891)
寺谷 工  自治医科大学, 医学部, 講師 (70373404)
藤本 康弘  京都大学, 医学研究科, 客員研究員 (80335281)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords褐色脂肪細胞 / 表面マーカー / 細胞移植 / 褐色細胞腫 / 脂肪幹細胞 / 肥満治療 / 非アルコール性脂肪肝炎 / 褐色脂肪 / 脂肪肝 / 肥満 / NASH
Outline of Final Research Achievements

Brown adipocytes play a central role in regulating metabolism and generating metabolic signals. They are also important to maintain metabolic homeostasis by adjusting energy expenditure. However, these cells are not yet well-understood and the tissue-specific presence of uncoupling protein 1 (UCP-1) is a promising lead to gain further understanding. Pheocromocytomas are known to have a tendency to grow into surrounding adipose tissue and become brown adipose tissue. We have successfully collected and cultured these cells from a patient with a pheocromocytoma. There is very little knowledge about Brown adipocytes except for the presence of UCP-1. We performed fluorescence-activated cell sorting combined with a UCP-1 specific aptamer. Cell surface makers were detected using gene-tip analysis and showed CD9, CD177, CD200:positive、and CD40, CD44, CD109: negative.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 10 results)

  • [Journal Article] Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report.2016

    • Author(s)
      Yamada N, Sanada Y, Katano T, Tashiro M, Hirata Y, Okada N, Ihara Y, Miki A, Sasanuma H, Urahashi T, Sakuma Y, Mizuta K.
    • Journal Title

      World J Gastroenterol

      Volume: 22 Pages: 9865-9870

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical evaluation for outflow reconstruction using opened round ligament in living donor right posterior sector graft liver transplantation: A case report.2016

    • Author(s)
      Sanada Y
    • Journal Title

      World J Gastroenterol

      Volume: 22(34) Issue: 34 Pages: 7851-6

    • DOI

      10.3748/wjg.v22.i34.7851

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] COMPLEMENTARY INDICATORS FOR DIAGNOSIS OF HEPATIC VEIN STENOSIS AFTER PEDIATRIC LIVING DONOR LIVER TRANSPLANTATION2016

    • Author(s)
      Kawano Youichi
    • Journal Title

      Transplantation Proceedings

      Volume: S0041 Issue: 4 Pages: 234-237

    • DOI

      10.1016/j.transproceed.2015.12.114

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Living-Donor Liver Transplantation Using Segment 2 Monosegment Graft: A Single-Center Experience.2016

    • Author(s)
      Sakuma Y
    • Journal Title

      Transplant Proc

      Volume: 48(4) Issue: 4 Pages: 1110-4

    • DOI

      10.1016/j.transproceed.2015.12.119

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The outcomes of pediatric living donor liver transplantation using small-for-size grafts: experience of a single institute.2016

    • Author(s)
      Yamada N, Sanada Y, Hirata Y, Okada N, Ihara Y, Sasanuma H, Urahashi T, Sakuma Y, Yasuda Y, Mizuta K
    • Journal Title

      Pediatr Surg Int.

      Volume: 19 Issue: 4 Pages: 363-368

    • DOI

      10.1007/s00383-016-3859-4

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation.2016

    • Author(s)
      Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, Sakuma Y, Yagisawa T
    • Journal Title

      Transpl Infect Dis

      Volume: 18 Issue: 2 Pages: 234-239

    • DOI

      10.1111/tid.12519

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selection of living donor liver grafts for patients weighing 6kg or less2015

    • Author(s)
      Naoya Yamada
    • Journal Title

      Liver Transplantation

      Volume: 21(2) Issue: 2 Pages: 233-238

    • DOI

      10.1002/lt.24048

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of rituximab in ABOincompatible pediatric living donor liver transplantation: The experience of a single center2015

    • Author(s)
      Noriki Okada, Yukihiro Sanada, Yuta Hirata, Naoya Yamada, Taiichi Wakiya, Yoshiyuki Ihara, Taizen Urahashi, Atsushi Miki, Yuji Kaneda, Hideki Sasanuma, Takehito Fujiwara, Yasunaru Sakuma, Atsushi Shimizu, Masanobu Hyodo, Yoshikazu Yasuda, Koichi Mizuta
    • Journal Title

      Pediatric Transplantation

      Volume: 19 Issue: 3 Pages: 279-286

    • DOI

      10.1111/petr.12445

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved human islet preparations using glucocorticoid and exendin-42014

    • Author(s)
      Atsushi Miki
    • Journal Title

      Pancreas

      Volume: 43(8) Issue: 8 Pages: 1317-1322

    • DOI

      10.1097/mpa.0000000000000184

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk Factors of Cytomegalovirus Infection After Pediatric Liver Transplantation2014

    • Author(s)
      Y. Kawano, K. Mizuta, Y. Sanada, T. Urahashi, Y. Ihara, N. Okada, N. Yamada, H. Sasanuma, Y. Sakuma, N. Taniai, H. Yoshida, H. Kawarasaki, Y. Yasuda, and E. Uchida
    • Journal Title

      Transplantation Proceedings

      Volume: 46 Issue: 10 Pages: 3543-3547

    • DOI

      10.1016/j.transproceed.2014.09.150

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2014-04-04   Modified: 2021-03-11  

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